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    Jackson, K.G. and Minihane, A.M. 2013. Bioactive Food as Dietary Interventions for Cardiovascular Disease.


    Jackson, Kim G. Poppitt, Sally D. and Minihane, Anne M. 2012. Postprandial lipemia and cardiovascular disease risk: Interrelationships between dietary, physiological and genetic determinants. Atherosclerosis, Vol. 220, Issue. 1, p. 22.


    Anderson, Jennifer S. Nettleton, Jennifer A. Hundley, W. Gregory Tsai, Michael Y. Steffen, Lyn M. Lemaitre, Rozenn N. Siscovick, David Lima, João Prince, Martin R. and Herrington, David 2011. Associations of Plasma Phospholipid Omega-6 and Omega-3 Polyunsaturated Fatty Acid Levels and MRI Measures of Cardiovascular Structure and Function: The Multiethnic Study of Atherosclerosis. Journal of Nutrition and Metabolism, Vol. 2011, p. 1.


    Egert, Sarah and Stehle, Peter 2011. Impact of n − 3 fatty acids on endothelial function: results from human interventions studies. Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 14, Issue. 2, p. 121.


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The impact of age on the postprandial vascular response to a fish oil-enriched meal

  • Kim G. Jackson (a1), Christopher K. Armah (a1), Izzy Doman (a1), Lewis James (a1), Farah Cheghani (a1) and Anne M. Minihane (a1)
  • DOI: http://dx.doi.org/10.1017/S0007114509990742
  • Published online: 29 June 2009
Abstract

Although chronic fish oil intervention had been shown to have a positive impact on vascular reactivity, very little is known about their acute effects during the postprandial phase. Our aim was to examine the impact of a fish oil-enriched test meal on postprandial vascular reactivity in healthy younger ( < 50 years) v. older ( ≥ 50 years) men. Vascular reactivity was measured at baseline (0 h), 2 and 4 h after the meal by laser Doppler iontophoresis and blood samples taken at 0 and 4 h for the measurement of plasma lipids, total nitrite, glucose and insulin. Acetylcholine- (ACh, endothelial-dependent vasodilator) and sodium nitroprusside (SNP, endothelial-independent vasodilator)-induced reactivities were greater at 4 h than at baseline or 2 h in the younger men (P < 0·04). These changes were not observed in the older men. Comparison of the male groups revealed significantly greater responses to ACh (P = 0·006) and SNP (P = 0·05) at 4 h in the younger compared with the older males. Postprandial NEFA concentrations were also greater at 4 h in the younger compared with the older men (P = 0·005), with no differences observed for any of the other analytes. Multiple regression analysis revealed age to be the most significant predictor of both ACh and SNP induced reactivity 4 h after the meal. In conclusion, the ingestion of a meal enriched in fish oil fatty acids was shown to improve postprandial vascular reactivity at 4 h in our younger men, with little benefit evident in our older men.

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Corresponding author
*Corresponding author: Dr Kim G. Jackson, fax +44 118 931 0080, email k.g.jackson@reading.ac.uk
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1DHJ Thijssen , P de Groot , M Kooijman , (2006) Sympathetic nervous system contributes to the age-related impairment of flow mediated dilation of the superficial femoral artery. Am J Physiol Heart Circ Physiol 291, H3122H3129.

5F Franzoni , L Ghiadoni , F Galetta , (2005) Physical activity, plasma antioxidant capacity, and endothelium-dependent vasodilation in young and older men. Am J Hypertens 18, 510516.

10TA Mori , GF Watts , V Burke , (2000) Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidaemic, overweight men. Circulation 102, 12641269.

13RA Vogel , MC Corretti & GD Plotnick (2000) The postprandial effect of components of the Mediterranean Diet on endothelial function. J Am Coll Cardiol 36, 455460.

14SG West , KD Hecker , VA Mustad , (2005) Acute effects of monounsaturated fatty acids with and without omega-3 fatty acids on vascular reactivity in individuals with type 2 diabetes. Diabetologia 48, 113122.

15CK Armah , KG Jackson , L James , (2008) Fish oil fatty acids improve postprandial vascular reactivity in healthy men. Clin Sci 114, 679686.

21DS Celermajer , KE Sorensen , DJ Spiegelhalter , (1994) Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol 24, 471476.

23M Gerhard , MA Roddy , SJ Creager , (1996) Aging progressively impairs endothelium dependent vasodilation in forearm resistance vessels of humans. Hypertension 27, 849853.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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