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The relationship between zinc intake and serum/plasma zinc concentration in adults: a systematic review and dose–response meta-analysis by the EURRECA Network

  • Nicola M. Lowe (a1), Marisol Warthon Medina (a1), Anna-Louise Stammers (a1), Sujata Patel (a1), Olga W. Souverein (a2), Carla Dullemeijer (a2), Lluis Serra-Majem (a3), Mariela Nissensohn (a3) and Victoria Hall Moran (a4)
  • DOI: http://dx.doi.org/10.1017/S0007114512004382
  • Published online: 13 November 2012
Abstract

Dietary Zn recommendations vary widely across Europe due to the heterogeneity of approaches used by expert panels. Under the EURopean micronutrient RECommendations Aligned (EURRECA) consortium a protocol was designed to systematically review and undertake meta-analyses of research data to create a database that includes ‘best practice’ guidelines which can be used as a resource by future panels when setting micronutrient recommendations. As part of this process, the objective of the present study was to undertake a systematic review and meta-analysis of previously published data describing the relationship between Zn intake and status in adults. Searches were performed of literature published up to February 2010 using MEDLINE, Embase and the Cochrane Library. Data extracted included population characteristics, dose of Zn, duration of study, dietary intake of Zn, and mean concentration of Zn in plasma or serum at the end of the intervention period. An intake–status regression coefficient ($\circ {>\beta }$) was estimated for each individual study, and pooled meta-analysis undertaken. The overall pooled $\circ {>\beta }$ for Zn supplementation on serum/plasma Zn concentrations from randomised controlled trials and observational studies was 0·08 (95 % CI 0·05, 0·11; P < 0·0001; I2 84·5 %). An overall $\circ {>\beta }$ of 0·08 means that for every doubling in Zn intake, the difference in Zn serum or plasma concentration is $2^{ \circ {>\beta }}$ (20·08 = 1·06), which is 6 %. Whether the dose–response relationship, as provided in the present paper, could be used as either qualitative or quantitative evidence to substantiate the daily Zn intake dose necessary to achieve normal or optimal levels of biomarkers for Zn status remains a matter of discussion.

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*Corresponding author: Nicola Lowe, fax +44 1772 892925, email NMLowe@uclan.ac.uk
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1EL Doets , LS de Wit , RAM Dhonukshe-Rutten , et al. (2008) Current micronutrient recommendations in Europe: towards understanding their differences and similarities. Eur J Nutr 47, 1740.

2C Matthys , P van 't Veer , L de Groot , et al. (2011) EURRECA's approach for estimating micronutrient requirements. Int J Vitam Nutr Res 81, 256263.

3JC King (2011) Zinc: an essential but elusive nutrient. Am J Clin Nutr 94, 679S684S.

4NM Lowe , K Fekete & T Decsi (2009) Methods of assessment of zinc status in humans: a systematic review. Am J Clin Nutr 89, 2040S2051S.

5M Abdulla & S Svensson (1979) Effect of oral zinc intake on δ-aminolaevulinic acid dehydratase in red blood cells. Scand J Clin Lab Invest 39, 3136.

11M Sakagami , M Ikeda , H Tomita , et al. (2009) A zinc-containing compound, Polaprezinc, is effective for patients with taste disorders: randomized, double-blind, placebo-controlled, multi-center study. Acta Otolaryngol 129, 11151120.

12P Preziosi , P Galan , B Herbeth , et al. (1998) Effects of supplementation with a combination of antioxidant vitamins and trace elements, at nutritional doses, on biochemical indicators and markers of the antioxidant system in adult subjects. J Am Coll Nutr 17, 244249.

14C Sánchez , M Lopez-Jurado , E Planells , et al. (2009) Assessment of iron and zinc intake and related biochemical parameters in an adult Mediterranean population from southern Spain: influence of lifestyle factors. J Nutr Biochem 20, 125131.

15IM Rea (1989) Sex and age-changes in serum zinc levels. Nutr Res 9, 121125.

16OW Souverein , C Dullemeijer , P van 't Veer , et al. (2012) Transformations of summary statistics as input in meta-analysis for linear dose-response models on a logarithmic scale: a methodology developed within EURRECA. BMC Med Res Methodol 12, 57.

17R DerSimonian & N Laird (1986) Meta-analysis in clinical trials. Control Clin Trials 7, 177188.

20RK Chandyo , TA Strand , M Mathisen , et al. (2009) Zinc deficiency is common among healthy women of reproductive age in Bhaktapur, Nepal. J Nutr 139, 594597.

21V Kipnis , AF Subar , D Midthune , et al. (2003) Structure of dietary measurement error: results of the OPEN biomarker study. Am J Epidemiol 158, 1421.

22VH Moran , AL Skinner , MW Medina , et al. (2012) The relationship between zinc intake and serum/plasma zinc Concentration in Children: a systematic review and dose–response meta-analysis. Nutrients 4, 841858.

25NM Lowe , LR Woodhouse & JC King (1998) A comparison of the short-term kinetics of zinc metabolism in women during fasting and following a breakfast meal. Br J Nutr 80, 363370.

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British Journal of Nutrition
  • ISSN: 0007-1145
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