Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 7
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Ahmad, Shaikh Meshbahuddin Hossain, Md Iqbal Bergman, Peter Kabir, Yearul and Raqib, Rubhana 2015. The effect of postpartum vitamin A supplementation on breast milk immune regulators and infant immune functions: study protocol of a randomized, controlled trial. Trials, Vol. 16, Issue. 1,


    Ahmad, Shaikh Meshbahuddin Raqib, Rubhana Qadri, Firdausi and Stephensen, Charles B. 2014. The effect of newborn vitamin A supplementation on infant immune functions: Trial design, interventions, and baseline data. Contemporary Clinical Trials, Vol. 39, Issue. 2, p. 269.


    Linderholm, Angela L. Bratt, Jennifer M. Schuster, Gertrud U. Zeki, Amir A. and Kenyon, Nicholas J. 2014. Novel Therapeutic Strategies for Adult Obese Asthmatics. Immunology and Allergy Clinics of North America, Vol. 34, Issue. 4, p. 809.


    Honarvar, Niyaz Mohammadzadeh Harrirchian, Mohammad Hossein koohdani, Fariba Siassi, Fereydoon Jafari Rad, Sima Abdolahi, Mina Bitarafan, Sama Salehi, Eisa Sahraian, Mohammad Ali Eshraghian, Mohammad Reza and Saboor-Yarghi, Ali Akbar 2013. In Vitro Effect of Human Serum and Fetal Calf Serum on CD4+ T Cells Proliferation in Response to Myelin Oligodendrocyte Glycoprotein (MOG) in Correlation with RBP/TTR Ratio in Multiple Sclerotic Patients. Journal of Molecular Neuroscience, Vol. 50, Issue. 3, p. 571.


    Wu, Jinhong Zhang, Yanjie Liu, Qi Zhong, Wenwei and Xia, Zhenwei 2013. All-trans retinoic acid attenuates airway inflammation by inhibiting Th2 and Th17 response in experimental allergic asthma. BMC Immunology, Vol. 14, Issue. 1, p. 28.


    Zavala, Gerardo Long, Kurt Z. García, Olga P. Caamaño, María del Carmen Aguilar, Tania Salgado, Luis M. and Rosado, Jorge L. 2013. Specific micronutrient concentrations are associated with inflammatory cytokines in a rural population of Mexican women with a high prevalence of obesity. British Journal of Nutrition, Vol. 109, Issue. 04, p. 686.


    Hall, Jason A. Grainger, John R. Spencer, Sean P. and Belkaid, Yasmine 2011. The Role of Retinoic Acid in Tolerance and Immunity. Immunity, Vol. 35, Issue. 1, p. 13.


    ×

Vitamin A status is associated with T-cell responses in Bangladeshi men

  • Shaikh M. Ahmad (a1) (a2), Marjorie J. Haskell (a1), Rubhana Raqib (a2) and Charles B. Stephensen (a1) (a3)
  • DOI: http://dx.doi.org/10.1017/S0007114509316165
  • Published online: 01 April 2009
Abstract

Recommendations for vitamin A intake are based on maintaining liver stores of ≥ 0·070 μmol/g, which is sufficient to maintain normal vision. We propose that higher levels may be required to maintain normal immune function. To test this hypothesis, we conducted an 8-week residential study among thirty-six healthy Bangladeshi men with low vitamin A stores. Subjects were randomised to receive vitamin A (240 mg in four doses) or placebo during study weeks 2 and 3. Vitamin A stores were estimated by isotopic dilution at week 8. Total T-cells, the naive T-cells:memory T-cells ratio and mitogen-induced lymphocyte proliferation were positively and significantly correlated with vitamin A stores (P < 0·05). Mitogen-stimulated IL-2, IL-4 and TNFα increased significantly (P < 0·05) in the vitamin A but not placebo group after supplementation, while IL-10 production was significantly and negatively correlated with vitamin A stores (P < 0·05). Segmented linear regression analysis revealed that naive T-cell counts and T-cell blastogenesis were positively associated with vitamin A stores above but not below 0·070 μmol/g liver. These data show that increasing vitamin A stores above the level that maintains normal vision enhances some measures of T-cell-mediated immunity, suggesting a difference in requirements for maintaining vision and immune function.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Vitamin A status is associated with T-cell responses in Bangladeshi men
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Vitamin A status is associated with T-cell responses in Bangladeshi men
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Vitamin A status is associated with T-cell responses in Bangladeshi men
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr Charles B. Stephensen, fax +1 530 752 5295, email cstephen@whnrc.usda.gov
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1CB Stephensen (2001) Vitamin A infection, and immune function. Annu Rev Nutr 21, 167192.

3Y Yang , S Minucci , K Ozato , (1995) Efficient inhibition of activation-induced Fas ligand up-regulation and T cell apoptosis by retinoids requires occupancy of both retinoid X receptors and retinoic acid receptors. J Biol Chem 270, 1867218677.

12A Coutsoudis , P Kiepiela , HM Coovadia , (1992) Vitamin A supplementation enhances specific IgG antibody levels and total lymphocyte numbers while improving morbidity in measles. Pediatr Infect Dis J 11, 203209.

13RD Semba , Muhilal, BJ Ward , (1993) Abnormal T-cell subset proportions in vitamin-A-deficient children. Lancet 341, 58.

14CS Benn , IM Lisse , C Bale , (2000) No strong long-term effect of vitamin A supplementation in infancy on CD4 and CD8 T-cell subsets. A community study from Guinea-Bissau, West Africa. Ann Trop Paediatr 20, 259264.

15JH Humphrey , T Quinn , D Fine , (1999) Short-term effects of large-dose vitamin A supplementation on viral load and immune response in HIV-infected women. J Acquir Immune Defic Syndr Hum Retrovirol 20, 4451.

16WW Fawzi , GI Msamanga , D Spiegelman , (1998) Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania. Lancet 351, 14771482.

17P Aukrust , F Muller , T Ueland , (2000) Decreased vitamin A levels in common variable immunodeficiency: vitamin A supplementation in vivo enhances immunoglobulin production and downregulates inflammatory responses. Eur J Clin Invest 30, 252259.

20SM Ahmad , MJ Haskell , R Raqib , (2009) Markers of innate immune function are associated with vitamin A stores in men. J Nutr 139, 377385.

27CL Mackall , TA Fleisher , MR Brown , (1995) Age, thymopoiesis, and CD4+T-lymphocyte regeneration after intensive chemotherapy. N Engl J Med 332, 143149.

28KY Smith , H Valdez , A Landay , (2000) Thymic size and lymphocyte restoration in patients with human immunodeficiency virus infection after 48 weeks of zidovudine, lamivudine, and ritonavir therapy. J Infect Dis 181, 141147.

31N Sidell , B Chang & L Bhatti (1993) Upregulation by retinoic acid of interleukin-2-receptor mRNA in human T lymphocytes. Cell Immunol 146, 2837.

32N Sidell & F Ramsdell (1988) Retinoic acid upregulates interleukin-2 receptors on activated human thymocytes. Cell Immunol 115, 299309.

40GU Schuster , NJ Kenyon & CB Stephensen (2008) Vitamin A deficiency decreases and high dietary vitamin A increases disease severity in the mouse model of asthma. J Immunol 180, 18341842.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: