Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 52
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Ahmad, Naveed Anwar, Farooq and Gilani, Anwar-ul-Hassan 2016. Essential Oils in Food Preservation, Flavor and Safety.


    Cunha, Jesse M. 2014. Testing Paternalism: Cash versus In-Kind Transfers†. American Economic Journal: Applied Economics, Vol. 6, Issue. 2, p. 195.


    Hill, Colin Guarner, Francisco Reid, Gregor Gibson, Glenn R. Merenstein, Daniel J. Pot, Bruno Morelli, Lorenzo Canani, Roberto Berni Flint, Harry J. Salminen, Seppo Calder, Philip C. and Sanders, Mary Ellen 2014. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nature Reviews Gastroenterology & Hepatology, Vol. 11, Issue. 8, p. 506.


    Shyu, Kou-Gi Chang, Chao-Chien Yeh, Yu-Chieh Sheu, Joen-Rong and Chou, Duen-Suey 2014. Mechanisms of Ascorbyl Radical Formation in Human Platelet-Rich Plasma. BioMed Research International, Vol. 2014, p. 1.


    Hemilä, Harri Chalker, Elizabeth and Hemilä, Harri 2013. Cochrane Database of Systematic Reviews.


    Constantini, Naama W. Dubnov-Raz, Gal Eyal, Ben-Bassat Berry, Elliot M. Cohen, Avner H. and Hemilä, Harri 2011. The effect of vitamin C on upper respiratory infections in adolescent swimmers: a randomized trial. European Journal of Pediatrics, Vol. 170, Issue. 1, p. 59.


    Orozco-Covarrubias, Luz and Durán McKinster, Carola 2011. Harper's Textbook of Pediatric Dermatology.


    Oster, Bernd and Fechtel, Ulrich 2011. Ullmann's Encyclopedia of Industrial Chemistry.


    Gershoff, Stanley N. 2009. Vitamin C (Ascorbic Acid): New Roles, New Requirements?. Nutrition Reviews, Vol. 51, Issue. 11, p. 313.


    Lee, Wang-Jae 2009. The Prospects of Vitamin C in Cancer Therapy. Immune Network, Vol. 9, Issue. 5, p. 147.


    Deruelle, Fabien and Baron, Bertrand 2008. Vitamin C: Is Supplementation Necessary for Optimal Health?. The Journal of Alternative and Complementary Medicine, Vol. 14, Issue. 10, p. 1291.


    Douglas, RM Hemilä, H Chalker, E and Treacy, B 2008. Cochrane review: Vitamin C for preventing and treating the common cold. Evidence-Based Child Health: A Cochrane Review Journal, Vol. 3, Issue. 3, p. 672.


    Marcos, A. Nova, E. and Lóez-Varela, S. 2008. Gut Flora, Nutrition, Immunity and Health.


    Hahm, Eunsil Jin, Dong-Hoon Kang, Jae Seung Kim, Young-In Hong, Seung-Woo Lee, Seung Koo Kim, Ha Na Jung, Da Jung Kim, Jee Eun Shin, Dong Hoon Hwang, Young Il Kim, Yeong Seok Hur, Dae Young Yang, Yoolhee Cho, Daeho Lee, Myeong-Sok and Lee, Wang Jae 2007. The molecular mechanisms of vitamin C on cell cycle regulation in B16F10 murine melanoma. Journal of Cellular Biochemistry, Vol. 102, Issue. 4, p. 1002.


    Hemilä, Harri Chalker, Elizabeth Douglas, Bob and Hemilä, Harri 2007. Cochrane Database of Systematic Reviews.


    Donabedian, Haig 2006. Nutritional therapy and infectious diseases: a two-edged sword. Nutrition Journal, Vol. 5, Issue. 1,


    Gruenwald, Joerg Graubaum, Hans-Joachim Busch, Regina and Bentley, Christine 2006. Safety and tolerance of Ester-C® compared with regular ascorbic acid. Advances in Therapy, Vol. 23, Issue. 1, p. 171.


    Hemilä, Harri Virtamo, Jarmo Albanes, Demetrius and Kaprio, Jaakko 2006. The Effect of Vitamin E on Common Cold Incidence Is Modified by Age, Smoking and Residential Neighborhood. Journal of the American College of Nutrition, Vol. 25, Issue. 4, p. 332.


    Douglas, RM Hemilä, H Chalker, E D'Souza, RRD Treacy, B and Hemilä, Harri 2004. Cochrane Database of Systematic Reviews.


    Cho, Daeho Hahm, Eunsil Kang, Jae Seung Kim, Young-In Yang, Yoolhee Park, Jong Hoon Kim, Daejin Kim, Seonghan Kim, Yeong Seok Hur, Daeyoung Park, Hyunjeong Pang, Saic Il Hwang, Young and Lee, Wang Jae 2003. Vitamin C downregulates interleukin-18 production by increasing reactive oxygen intermediate and mitogen-activated protein kinase signalling in B16F10 murine melanoma cells. Melanoma Research, Vol. 13, Issue. 6, p. 549.


    ×

Vitamin C and the common cold

  • Harri Hemilä (a1)
  • DOI: http://dx.doi.org/10.1079/BJN19920004
  • Published online: 01 March 2007
Abstract

The effect of vitamin C on the common cold has been the subject of several studies. These studies do not support a considerable decrease in the incidence of the common cold with supplemental vitamin C. However, vitamin C has consistently decreased the duration of cold episodes and the severity of symptoms. The benefits that have been observed in different studies show a large variation and, therefore, the clinical significance may not be clearly inferred from them. The biochemical explanation for the benefits may be based on the antioxidant property of vitamin C. In an infection, phagocytic leucocytes become activated and they produce oxidizing compounds which are released from the cell. By reacting with these oxidants, vitamin C may decrease the inflammatory effects caused by them. Scurvy, which is caused by a deficiency in vitamin C, is mostly attributed to the decreased synthesis of collagen. However, vitamin C also participates in several other reactions, such as the destruction of oxidizing substances. The common cold studies indicate that the amounts of vitamin C which safely protect from scurvy may still be too low to provide an efficient rate for other reactions, possibly antioxidant in nature, in infected people.

    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Vitamin C and the common cold
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Vitamin C and the common cold
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Vitamin C and the common cold
      Available formats
      ×
Copyright
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

J. S. Abramson & E. L. Mills (1988) Depression of neutrophil function by viruses and its role in secondary microbial infections. Reviews of Infectious Diseases 10, 326341.

R. Anderson & P. T. Lukey (1987) A biological role for ascorbate in the selective neutralization of extracellular phagocyte-derived oxidants. Annals of the New York Academy of Sciences 498, 229247.

R. Anderson & A. J. Theron (1990)Physiological potential of ascorbate, β-carotene and α-tocopherol individually and in combination in the prevention of tissue damage, carcinogenesis and immune dysfunction mediated by phagocyte-derived reactive oxidants. World Review of Nutrition and Dietetics 62, 2758.

L. A. Boxer , B. Vanderbilt , S. Bonsib , R. Jersild , H. H. Yang & R. L. Baehner (1979) Enhancement of chemotactic response and microtubule assembly in human leukocytes by ascorbic acid. Journal of Cellular Physiology 100, 119126.

C. Bucca , G. Rolla , W. Arossa , E. Caria , C. Elia , F. Nebiolo & S. Baldi (1989) Effect of ascorbic acid on increased bronchial responsiveness during upper airway infection. Respiration 55, 214219.

A. B. Carr , R. Einstein , Y. C. Lai , N. G. Martin & G. A. Starmer (1981) Vitamin C and the common cold: A second MZ co-twin control study. Acta Geneticae Medicae et Gemellologiae 30, 249255.

R. F. Cathcart (1981) Vitamin C, titrating to bowel tolerance, anascorbemia, and acute induced scurvy. Medical Hypotheses 7, 13591376.

T. C. Chalmers (1975) Effects of ascorbic acid on the common cold. An evaluation of the evidence. American Journal of Medicine 58, 532536.

G. C. Chatterjee , P. K. Majumder , S. K. Banerjee , R. K. Roy , B. Ray & D. Rudrapal (1975a) Relationships of protein and mineral intake to l-ascorbic acid metabolism, including considerations of some directly related hormones. Annals of the New York Academy of Sciences 258, 382400.

I. B. Chatterjee , S. Das Gupta , A. K. Majumder , B. K. Nandi & N. Subramanian (1975b) Effect of ascorbic acid on histamine metabolism in scorbutic guinea-pigs. Journal of Physiology 251, 271279.

I. B. Chatterjee , A. K. Majumder , B. K. Nandi & N. Subramanian (1975c) Synthesis and some major functions of vitamin C in animals. Annals of the New York Academy of Sciences 258, 2447.

M. V. Cohen (1989) Free radicals in ischemic and reperfusion myocardial injury: is this the time for clinical trials? Annals of Internal Medicine 111, 918931.

A. H. Conney , G. A. Bray , C. Evans & J. J. Burns (1961) Metabolic interactions between l-ascorbic acid and drugs. Annals of the New York Academy of Sciences 92, 115127.

J. L. Coulehan , S. Eberhard , L. Kapner , F. Taylor , K. Rogers & P. Garry (1976) Vitamin C and acute illness in Navajo schoolchildren. New England Journal of Medicine 295, 973977.

J. L. Coulehan , K. S. Reisinger , K. D. Rogers & D. W. Bradley (1974) Vitamin C prophylaxis in a boarding school. New England Journal of Medicine 290, 610.

D. W. Cowan , H. S. Diehl & A. B. Baker (1942) Vitamins for the prevention of colds. Journal of the American Medical Association 120, 12681271.

C. E. Cross , B. Halliwell , E. T. Borish , W. A. Pryor , B. N. Ames , R. L. Saul , J. M. McCord & D. Harman (1987) Oxygen radicals and human disease. Annals of Internal Medicine 107, 526545.

J. E. W. Davies , R. E. Hughes , E. Jones , S. E. Reed , J. W. Craig & D. A. J. Tyrrell (1979) Metabolism of ascorbic acid (vitamin C) in subjects infected with common cold viruses. Biochemical Medicine 21, 7885.

E. J. Jr Diliberto , F. S. Menniti , J. Knoth , A. J. Daniels , J. S. Kizer & O. H. Viveros (1987) Adrenomedullary chromaffin cells as a model to study the neurobiology of ascorbic acid: from monooxygenation to neuromodulation. Annals of the New York Academy of Sciences 498, 2853.

L. P. Dugal (1961) Vitamin C in relation to cold temperature tolerance. Annals of the New York Academy of Sciences 92, 307317.

M. H. M. Dykes & P. Meier (1975) Ascorbic acid and the common cold. Evaluation of its efficacy and toxicity. Journal of the American Medical Association 231, 10731079.

S. B. Eaton & M. Konner (1985) Paleolithic nutrition: a consideration of its nature and current implications. New England Journal of Medicine 312, 283289.

H. Faden , T. N. Kaul & P. L. Ogra (1983) Activation of oxidative and arachidonic acid metabolism in neutrophils by respiratory syncytial virus antibody complexes: possible role in disease. Journal of Infectious Diseases 148, 110116.

B. Frei , L. England & B. N. Ames (1989) Ascorbate is an outstanding antioxidant in human blood plasma. Proceedings of the National Academy of Sciences, U.S.A. 86, 63776381.

B. Frei , R. Stocker & B. N. Ames (1988) Antioxidant defenses and lipid peroxidation in human blood plasma. Proceedings of the National Academy of Sciences, U.S.A. 85, 97489752.

C. C. Glembotski (1987) The role of ascorbic acid in the biosynthesis of the neuroendocrine peptides α-MSH and TRH. Annals of the New York Academy of Sciences 498, 5461.

E. J. Goetzl , S. I. Wasserman , I. Gigli & K. F. Austen (1974) Enhancement of random migration and chemotactic response of human leukocytes by ascorbic acid. Journal of Clinical Investigation 53, 813818.

B. Halliwell & J. M. C. Gutteridge (1990) The antioxidants of human extracellular fluids. Archives of Biochemistry and Biophysics 280, 18.

B. Halliwell , M. Wasil & M. Grootveld (1987) Biologically significant scavenging of the myeloperoxidase-derived oxidant hypochlorous acid by ascorbic acid. FEBS Letters 213, 1518.

J. E. Heffner & J. E. Repine (1989) Pulmonary strategies of antioxidant defense. American Review of Respiratory Diseases 140, 531554.

H. Hemilä (1984) Nutritional need versus optimal intake. Medical Hypotheses 14, 135139.

H. Hemilä (1986) A re-evaluation of nutritional goals – not just deficiency counts. Medical Hypotheses 20, 1727.

H. Hemilä (1991) Is there a biochemical basis for ‘nutrient need’? Trends in Food Science and Technology 2, 73.

H. Hemilä , P. Roberts & M. Wikström (1984) Activated polymorphonuclear leucocytes consume vitamin C. FEBS Letters 178, 2530.

J. K. Hurst & W. C. Jr Barrette (1989) Leukocytic oxygen activation and microbicidal oxidative toxins. Critical Reviews in Biochemistry and Molecular Biology 24, 271328.

T. R. Karlowski , T. C. Chalmers , L. D. Frenkel , A. Z. Kapikian , T. L. Lewis & J. M. Lynch (1975) Ascorbic acid for the common cold. A prophylactic and therapeutic trial. Journal of the American Medical Association 231, 10381042.

A. J. Kettle & C. C. Winterbourn (1990) Superoxide enhances hypochlorous acid production by stimulated human neutrophils. Biochimica et Biophysica Acta 1052, 379385.

R. I. Lehrer , T. Ganz , M. E. Selsted , B. M. Babior & J. T. Curnutte (1988) Neutrophils and host defence. Annals of Internal Medicine 109, 127142.

R. F. Jr Lemanske , E. C. Dick , C. A. Swenson , R. F. Vrtis & W. W. Busse (1989) Rhinovirus upper respiratory infection increases airway hyperreactivity and late asthmatic reactions. Journal of Clinical Investigation 83, 110.

M. Levine & K. Morita (1985) Ascorbic acid in endocrine systems. Vitamins and Hormones 42, 164.

J. Ludvigsson , L. O. Hansson & G. Tibbling (1977) Vitamin C as a preventive medicine against common colds in children. Scandinavian Journal of Infectious Diseases 9, 9198.

D. J. Merchant (1950) The effect of serum on the activity of the polymorphonuclear leukocytes of the guinea pig. Journal of Infectious Diseases 87, 275284.

J. Z. Miller , W. E. Nance , J. A. Norton , R. L. Wolen , R. S. Griffith & R. J. Rose (1977) Therapeutic effect of vitamin C. A co-twin control study. Journal of the American Medical Association 237, 248251.

R. M. Naclerio , D. Proud , L. M. Lichtenstein , A. Kagey-Sobotka , J. O. Hendley , J. Sorrentino & J. M. Gwaltney (1988) Kinins are generated during experimental rhinovirus colds. Journal of Infectious Diseases 157, 133142.

J. Nath & J. I. Gallin (1983) Studies in normal and chronic granulomatous disease neutrophils indicate a correlation of tubulin tyrosinolation with the cellular redox state. Journal of Clinical Investigation 71, 12731281.

J. Nath & J. I. Gallin (1987) Effect of vitamin C on tubulin tyrosinolation in polymorphonuclear leukocytes. Annals of the New York Academy of Sciences 498, 216228.

W. J. Nungester & A. M. Ames (1948) The relationship between ascorbic acid and phagocytic activity. Journal of Infectious Diseases 83, 5054.

T. Oda , T. Akaike , T. Hamamoto , F. Suzuki , T. Hirano & H. Maeda (1989) Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD. Science 244, 974976.

L. Pauling (1970b) Evolution and the need for ascorbic acid. Proceedings of the National Academy of Sciences, U.S.A. 67, 16431648.

L. Pauling (1971a) The significance of the evidence about ascorbic acid and the common cold. Proceedings of the National Academy of Sciences, U.S.A. 68, 26782681.

H. A. Pitt & A. M. Costrini (1979) Vitamin C prophylaxis in marine recruits. Journal of the American Medical Association 241, 908911.

G. Ritzel (1976) Ascorbic acid and the common cold. Journal of the American Medical Association 235, 1108.

J. M. Rivers (1987) Safety of high-level vitamin C ingestion. Annals of the New York Academy of Sciences 498, 445454.

A. Samuni , J. Aronovitch , D. Godinger , M. Chevion & G. Czapski (1983) On the cytotoxicity of vitamin C and metal ions. European Journal of Biochemistry 137, 119124.

A. R. Schwartz , Y. Togo , R. B. Hornick , S. Tominaga & R. A. Gleckman (1973) Evaluation of the efficacy of ascorbic acid in prophylaxis of induced rhinovirus 44 infection in man. Journal of Infectious Diseases 128, 500505.

S. J. Sperber & F. G. Hayden (1988) Chemotherapy of rhinovirus colds. Antimicrobial Agents and Chemotherapy 32, 409419.

O. Stendahl , B.-I. Coble , C. Dahlgren , J. Hed & L. Molin (1984) Myeloperoxidase modulates the phagocytic acitivity of polymorphonuclear neutrophil leukocytes. Journal of Clinical Investigation 73, 366373.

N. Subramanian (1978) Histamine degradative potential of ascorbic acid: considerations and evaluations. Agents and Actions 8, 484487.

S. R. Tannenbaum & J. S. Wishnok (1987) Inhibition of nitrosamine formation by ascorbic acid. Annals of the New York Academy of Sciences 498, 354363.

M.-F. Tsan (1980) Phorbol myristrate acetate induced neutrophil autotoxicity. Journal of Cellular Physiology 105, 327334.

R. B. Turner (1988) Rhinovirus infection of human embryonic lung fibroblasts induces the production of a chemoattractant for polymorphonuclear leukocytes. Journal of Infectious Diseases 157, 346350.

R. B. Turner , J. O. Hendley & J. M. Jr. Gwaltney (1982) Shedding of infected ciliated epithelial cells in rhinovirus colds. Journal of Infectious Diseases 145, 849853.

Y. Wang & B. V. Ness (1989) Site-specific cleavage of supercoiled DNA by ascorbate/Cu(II). Nucleic Acids Research 17, 69156926.

R. C. Welliver , D. T. Wong , M. Sun , E. Middleton , R. S. Vaughan & P. L. Ogra (1981) The development of respiratory syncytial virus-specific IgE and the release of histamine in nasopharyngeal secretions after infection. New England Journal of Medicine 305, 841846.

C. W. M. Wilson (1975) Ascorbic acid function and metabolism during colds. Annals of the New York Academy of Sciences 258, 529539.

C. C. Winterbourn & M. C. M. Vissers (1983) Changes in ascorbate levels on stimulation of human neutrophils. Biochimica et Biophysica Acta 763, 175179.

B. Winther , S. Brofeldt , B. Christensen & N. Mygind (1984a) Light and scanning electron microscopy of nasal biopsy material from patients with naturally acquired common colds. Acta Otolaryngologica 97, 309318.

B. Winther , B. Farr , R. B. Turner , J. O. Hendley , J. M. Jr. Gwaltney & N. Mygind (1984b) Histopathologic examination and enumeration of polymorphonuclear leukocytes in the nasal mucosa during experimental rhinovirus colds. Acta Otolaryngologica Suppl.413, 1924.

B. Winther , J. M. Gwaltney & J. O. Hendley (1990) Respiratory virus infection of monolayer cultures of human nasal epithelial cells. American Review of Respiratory Diseases 141, 839845.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: