Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 10
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Thota, Prashanthi N. Kistangari, Gaurav Singh, Prabhdeep Cummings, Linda Hajifathalian, Kaveh Lopez, Rocio and Sanaka, Madhusudhan R. 2016. Serum 25-Hydroxyvitamin D Levels and the Risk of Dysplasia and Esophageal Adenocarcinoma in Patients with Barrett’s Esophagus. Digestive Diseases and Sciences, Vol. 61, Issue. 1, p. 247.


    Brown, Craig S. Lapin, Brittany Wang, Chi Goldstein, Jay L. Linn, John G. Denham, Woody Haggerty, Stephen P. Talamonti, Mark S. Howington, John A. Carbray, Joann and Ujiki, Michael B. 2014. Predicting regression of Barrett’s esophagus: results from a retrospective cohort of 1342 patients. Surgical Endoscopy, Vol. 28, Issue. 10, p. 2803.


    Han, Y J Li, J Huang, W Fang, Y Xiao, L N and Liao, Z' E 2013. Fish consumption and risk of esophageal cancer and its subtypes: a systematic review and meta-analysis of observational studies. European Journal of Clinical Nutrition, Vol. 67, Issue. 2, p. 147.


    Huang, Wen Han, Yujing Xu, Jiping Zhu, Wei and Li, Zhaoshen 2013. Red and processed meat intake and risk of esophageal adenocarcinoma: a meta-analysis of observational studies. Cancer Causes & Control, Vol. 24, Issue. 1, p. 193.


    Trowbridge, Ryan Kizer, Robert T Mittal, Sumeet K and Agrawal, Devendra K 2013. 1,25-dihydroxyvitamin D in the pathogenesis of Barrett’s esophagus and esophageal adenocarcinoma. Expert Review of Clinical Immunology, Vol. 9, Issue. 6, p. 517.


    van de Winkel, A. Massl, R. Kuipers, E. J. van der Laan, L. J. W. and Peppelenbosch, M. P. 2013. Digestive Disease Week 2011: highlights of clinical and preclinical research on Barrett's esophagus and associated esophageal adenocarcinoma. Diseases of the Esophagus, Vol. 26, Issue. 2, p. 130.


    Wulaningsih, Wahyu Michaelsson, Karl Garmo, Hans Hammar, Niklas Jungner, Ingmar Walldius, Göran Holmberg, Lars and Van Hemelrijck, Mieke 2013. Inorganic phosphate and the risk of cancer in the Swedish AMORIS study. BMC Cancer, Vol. 13, Issue. 1,


    Wulaningsih, Wahyu Michaelsson, Karl Garmo, Hans Hammar, Niklas Jungner, Ingmar Walldius, Göran Lambe, Mats Holmberg, Lars and Van Hemelrijck, Mieke 2013. Serum calcium and risk of gastrointestinal cancer in the Swedish AMORIS study. BMC Public Health, Vol. 13, Issue. 1,


    Cantwell, Marie M. 2012. The Role of Diet in Cancer Development and Prevention. Current Nutrition Reports, Vol. 1, Issue. 1, p. 1.


    Miller, Keith R. and Bozeman, Matthew C. 2012. Nutrition Therapy Issues in Esophageal Cancer. Current Gastroenterology Reports, Vol. 14, Issue. 4, p. 356.


    ×

Vitamin D, calcium and dairy intake, and risk of oesophageal adenocarcinoma and its precursor conditions

  • Helen G. Mulholland (a1), Liam J. Murray (a1), Lesley A. Anderson (a1) and Marie M. Cantwell (a1)
  • DOI: http://dx.doi.org/10.1017/S0007114511000742
  • Published online: 09 May 2011
Abstract

Evidence is accumulating that vitamin D may be protective against carcinogenesis, although exceptions have been observed for some digestive tract neoplasms. The aim of the present study was to explore the association between dietary vitamin D and related nutrients and the risk of oesophageal adenocarcinoma and its precursor conditions, Barrett's oesophagus and reflux oesophagitis. In an all-Ireland case–control study conducted between March 2002 and July 2005, 218 oesophageal adenocarcinoma patients, 212 Barrett's oesophagus patients, 208 reflux oesophagitis patients and 252 population-based controls completed a 101-item FFQ, and provided lifestyle and demographic information. Multiple logistic regression analysis was applied to examine the association between dietary intake and disease risk. Oesophageal adenocarcinoma risk was significantly greater for individuals with the highest compared with the lowest tertile of vitamin D intake (OR 1·99, 95 % CI 1·03, 3·86; P for trend = 0·02). The direct association could not be attributed to a particular vitamin D food source. Vitamin D intake was unrelated to Barrett's oesophagus and reflux oesophagitis risk. No significant associations were observed for Ca or dairy intake and oesophageal adenocarcinoma, Barrett's oesophagus or reflux oesophagitis development. High vitamin D intake may increase oesophageal adenocarcinoma risk but is not related to reflux oesophagitis and Barrett's oesophagus. Ca and dairy product intake did not influence the development of these oesophageal lesions. These findings suggest that there may be population subgroups at an increased risk of oesophageal adenocarcinoma if advice to improve vitamin D intake from foods is implemented. Limited work has been conducted in this area, and further research is required.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Vitamin D, calcium and dairy intake, and risk of oesophageal adenocarcinoma and its precursor conditions
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Vitamin D, calcium and dairy intake, and risk of oesophageal adenocarcinoma and its precursor conditions
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Vitamin D, calcium and dairy intake, and risk of oesophageal adenocarcinoma and its precursor conditions
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr H. G. Mulholland, fax +44 2890235900, email h.mulholland@qub.ac.uk
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1C Lepage , B Rachet , V Jooste , (2008) Continuing rapid increase in esophageal adenocarcinoma in England and Wales. Am J Gastroenterol 103, 26942699.

2HB El-Serag (2007) Time trends of gastroesophageal reflux disease: a systematic review. Clin Gastroenterol Hepatol 5, 1726.

3NJ Shaheen & JE Richter (2009) Barrett's oesophagus. Lancet 373, 850861.

4RK Wood & YX Yang (2008) Barrett's esophagus in 2008: an update. Keio J Med 57, 132138.

5F Yousef , C Cardwell , MM Cantwell , (2008) The incidence of esophageal cancer and high-grade dysplasia in Barrett's esophagus: a systematic review and meta-analysis. Am J Epidemiol 168, 237249.

6T Thomas , KR Abrams , JS De Caestecker , (2007) Meta analysis: cancer risk in Barrett's oesophagus. Aliment Pharmacol Ther 26, 14651477.

7P Terry , J Lagergren , A Wolk , (2000) Reflux-inducing dietary factors and risk of adenocarcinoma of the esophagus and gastric cardia. Nutr Cancer 38, 186191.

8HB El-Serag , JA Satia & L Rabeneck (2005) Dietary intake and the risk of gastro-oesophageal reflux disease: a cross sectional study in volunteers. Gut 54, 1117.

9LA Anderson , RG Watson , SJ Murphy , (2007) Risk factors for Barrett's oesophagus and oesophageal adenocarcinoma: results from the FINBAR study. World J Gastroenterol 13, 15851594.

10A Kubo , TR Levin , G Block , (2008) Dietary antioxidants, fruits, and vegetables and the risk of Barrett's esophagus. Am J Gastroenterol 103, 16141623, quiz 1624.

11OM Thompson , SA Beresford , EA Kirk , (2009) Vegetable and fruit intakes and risk of Barrett's esophagus in men and women. Am J Clin Nutr 89, 890896.

13HG Mulholland , MM Cantwell , LA Anderson , (2009) Glycemic index, carbohydrate and fiber intakes and risk of reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma. Cancer Causes Control 20, 279288.

14E Giovannucci (2008) Vitamin D and cancer incidence in the Harvard cohorts. Ann Epidemiol 19, 8488.

15AS Dusso , AJ Brown & E Slatopolsky (2005) Vitamin D. Am J Physiol Renal Physiol 289, F828.

16ED Gorham , CF Garland , FC Garland , (2007) Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. Am J Prev Med 32, 210216.

17MY Wei , CF Garland , ED Gorham , (2008) Vitamin D and prevention of colorectal adenoma: a meta-analysis. Cancer Epidemiol Biomarkers Prev 17, 29582969.

18RZ Stolzenberg-Solomon , R Vieth , A Azad , (2006) A prospective nested case–control study of vitamin D status and pancreatic cancer risk in male smokers. Cancer Res 66, 1021310219.

19CC Abnet , W Chen , SM Dawsey , (2007) Serum 25(OH)-vitamin D concentration and risk of esophageal squamous dysplasia. Cancer Epidemiol Biomarkers Prev 16, 18891893.

20W Chen , SM Dawsey , YL Qiao , (2007) Prospective study of serum 25(OH)-vitamin D concentration and risk of oesophageal and gastric cancers. Br J Cancer 97, 123128.

22LA Anderson , BT Johnston , RG Watson , (2006) Nonsteroidal anti-inflammatory drugs and the esophageal inflammation-metaplasia-adenocarcinoma sequence. Cancer Res 66, 49754982.

23DS Nayar & MF Vaezi (2004) Classifications of esophagitis: who needs them? Gastrointest Endosc 60, 253257.

25KE Harrington , PJ Robson , M Kiely , (2001) The North/South Ireland Food Consumption Survey: survey design and methodology. Public Health Nutr 4, 10371042.

26LA Anderson , SJ Murphy , BT Johnston , (2008) Relationship between Helicobacter pylori infection and gastric atrophy and the stages of the oesophageal inflammation, metaplasia, adenocarcinoma sequence: results from the FINBAR case–control study. Gut 57, 734739.

28SA Navarro Silvera , ST Mayne , H Risch , (2008) Food group intake and risk of subtypes of esophageal and gastric cancer. Int J Cancer 123, 852860.

29CF Garland , FC Garland , ED Gorham , (2006) The role of vitamin D in cancer prevention. Am J Public Health 96, 252261.

31M Kull , R Kallikorm & M Lember (2009) Body mass index determines sunbathing habits: implications on vitamin D levels. Intern Med J 39, 256258.

32S Konradsen , H Ag , F Lindberg , (2008) Serum 1,25-dihydroxy vitamin D is inversely associated with body mass index. Eur J Nutr 47, 8791.

35CC Abnet , Y Chen , WH Chow , (2010) Circulating 25-hydroxyvitamin D and risk of esophageal and gastric cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol 172, 94106.

36S Nishida , J Ozeki & M Makishima (2009) Modulation of bile acid metabolism by 1alpha-hydroxyvitamin D3 administration in mice. Drug Metab Dispos 37, 20372044.

37H Bernstein , C Bernstein , CM Payne , (2005) Bile acids as carcinogens in human gastrointestinal cancers. Mutat Res 589, 4765.

38KJ Helzlsouer & VDPP Steering Committee (2010) Overview of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol 172, 49.

39RZ Stolzenberg-Solomon , EJ Jacobs , AA Arslan , (2010) Circulating 25-hydroxyvitamin D and risk of pancreatic cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol 172, 8193.

40AE Millen , J Wactawski-Wende , M Pettinger , (2010) Predictors of serum 25-hydroxyvitamin D concentrations among postmenopausal women: the Women's Health Initiative Calcium plus Vitamin D clinical trial. Am J Clin Nutr 91, 13241335.

43M O'Sullivan , T Nic Suibhne , G Cox , (2008) High prevalence of vitamin D insufficiency in healthy Irish adults. Ir J Med Sci 177, 131134.

44RC Fitzgerald (2004) Review Article: Barrett's oesophagus and associated adenocarcinoma – a UK perspective. Aliment Pharmacol Ther 20, Suppl. 8, 4549.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: