1Bik, EM (2009) Composition and function of the human associated microbiota. Nutr Rev 67, S164–S171.
2DiBaise, JK, Zhang, H, Crowell, MD, et al. (2008) Gut microbiota and its possible relationship with obesity. Mayo Clin Proc 83, 460–469.
3Gibson, GR & Roberfroid, MB (1995) Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 125, 1401–1412.
4Gibson, GR, Probert, HM, Loo, JV, et al. (2004) Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutr Res Rev 17, 259–279.
5Roberfroid, M, Gibson, GR, Hoyles, L, et al. (2010) Prebiotic effects: metabolic and health benefits. Br J Nutr 104, Suppl. S2, S1–S63.
6Roberfroid, MB, Bornet, F, Bouley, C, et al. (1995) Colonic microflora: nutrition and health. Summary and conclusions of an International Life Sciences Institute (ILSI) [Europe] workshop held in Barcelona, Spain. Nutr Rev 53, 127–130.
7Lomax, AR & Calder, PC (2009) Prebiotics, immune function, infection and inflammation: a review of the evidence. Br J Nutr 101, 633–658.
8Hotamisligil, GS (2006) Inflammation and metabolic disorders. Nature 444, 860–867.
9Creely, SJ, McTernan, PG, Kusminski, CM, et al. (2007) Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. Am J Physiol Endocrinol Metab 292, E740–E747.
10Cani, PD, Neyrinck, AM, Fava, F, et al. (2007) Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice though a mechanism associated with endotoxaemia. Diabetologia 50, 2374–2383.
11Cani, PD, Bibiloni, R, Knauf, C, et al. (2008) Changes in gut microbiota control metabolic endotoxemia induced inflammation in high fat diet induced obesity and diabetes in mice. Diabetes 57, 1470–1481.
12Erridge, C, Attina, T, Spickett, CM, et al. (2007) A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation. Am J Clin Nutr 86, 1286–1292.
13Hotamisligil, GS & Erbay, E (2008) Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol 8, 923–934.
14Shoelson, SE & Goldfine, AB (2009) Getting away from glucose: fanning the flames of obesity-induced inflammation. Nat Med 15, 373–974.
15Chow, JC, Young, DW, Golenbock, DT, et al. (1999) Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 274, 10689–10692.
16Wright, SD, Ramos, RA, Tobias, PS, et al. (1990) CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249, 1431–1433.
17Paineau, D, Payen, F, Panserieu, S, et al. (2008) The effects of regular consumption of short-chain fructo-oligosaccharides on digestive comfort of subjects with minor functional bowel disorders. Br J Nutr 99, 311–318.
18Pouillart, PR, Dépeint, F, Abdelnour, A, et al. (2010) Nutriose, a prebiotic low-digestible carbohydrate, stimulates gut mucosal immunity and prevents TNBS-induced colitis in piglets. Inflamm Bowel Dis 16, 783–794.
19Scheppach, WM, Fabian, CE & Kasper, HW (1987) Fecal short-chain fatty acid (SCFA) analysis by capillary gas–liquid chromatography. Am J Clin Nutr 46, 641–646.
20Birkett, AM, Jones, GP & Muir, JG (1995) Simple high-performance liquid chromatographic analysis of phenol and p-cresol in urine and feces. J Chromatogr Biomed Appl 674, 187–191.
21Djouzi, Z, Andrieux, C, Degivry, MC, et al. (1997) The association of yogurt starters with Lactobacillus casei DN 114.001 in fermented milk alters the composition and metabolism of intestinal microflora in germ-free rats and in human flora-associated rats. J Nutr 127, 2260–2266.
22Abdel Nour, AM, Dépeint, F, Barbour, EK, et al. (2010) Ex-vivo LPS stimulation model coupled with quantitative PCR and its multispecies application in immunonutrition. Eur Pharm Rev Dig 15, 31–35.
24Bouhnik, Y, Raskine, L, Simoneau, G, et al. (2004) The capacity of nondigestible carbohydrates to stimulate fecal bifidobacteria in healthy humans: a double-blind, randomized, placebo-controlled, parallel-group, dose–response relation study. Am J Clin Nutr 80, 1658–1664.
25Bach Knudsen, KE & Hessov, I (1995) Recovery of inulin from Jerusalem artichoke (Helianthus tuberosus L.) in the small intestine of man. Br J Nutr 74, 101–113.
26Kolida, S, Meyer, D & Gibson, GR (2007) A double-blind placebo-controlled study to establish the bifidogenic dose of inulin in healthy humans. Eur J Clin Nutr 60, 1189–1195.
27Bouhnik, Y, Raskine, L, Champion, K, et al. (2007) Prolonged administration of low-dose inulin stimulates the growth of bifidobacteria in humans. Nutr Res 27, 187–193.
28Marteau, P, Jacobs, H, Cazaubiel, M, et al. (2011) Effects of chicory inulin in constipated elderly people: a double-blind controlled trial. Int J Food Sci Nutr 62, 164–170.
29Meyer, D & Stasse-Wolthuis, M (2009) The bifidogenic effect of inulin and oligofructose and its consequences for gut health. Eur J Clin Nutr 63, 1277–1289.
30Chung, YC, Hsu, CK, Ko, CY, et al. (2007) Dietary intake of xylooligosaccharides improves the intestinal microbiota, fecal moisture, and pH value in the elderly. Nutr Res 27, 756–761.
31Grootaert, C, Delcour, JA, Courtin, CM, et al. (2007) Microbial metabolism and prebiotic potency of arabinoxylan oligosaccharides in the human intestine. Trends Food Sci Technol 18, 64–71.
32Yamada, H, Itoh, K, Morishita, Y, et al. (1993) Structure and properties of oligosaccharides from wheat bran. In Symposium on Technical Advances in Japan: The American Association of Cereal Chemistry (AACC), Annual Meeting, Minneapolis, MN.
33Cloetens, L (2009) .
34Cloetens, L, Broekaert, WF, Delaedt, Y, et al. (2010) Tolerance of arabinoxylan-oligosaccharides and their prebiotic activity in healthy subjects: a randomised, placebo-controlled cross-over study. Br J Nutr 103, 703–713.
35Cloetens, L, De Preter, V, Swennen, K, et al. (2008) Dose–response effect of arabinoxylooligosaccharides on gastrointestinal motility and on colonic bacterial metabolism in healthy volunteers. J Am Coll Nutr 27, 512–518.
36Pasman, W, Wills, D, Saniez, MH, et al. (2006) Long-term gastrointestinal tolerance of NUTRIOSE FB in healthy men. Eur J Clin Nutr 60, 1024–1034.
37Louis, P & Flint, HJ (2009) Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine. FEMS Microbiol Lett 294, 1–8.
38Grasten, S, Liukkonen, KH, Chrevatidis, A, et al. (2003) Effects of wheat pentosan and inulin on the metabolic activity of fecal microbiota and on bowel function in healthy humans. Nutr Res 23, 1503–1514.
39Pouillart, PR (1998) Role of butyric acid and its derivatives in the treatment of colorectal cancer and hemoglobinopathies. Life Sci 63, 1739–1760.
40Pool-Zobel, BL (2005) Inulin-type fructans and reduction in colon cancer risk: review of experimental and human data. Br J Nutr 93, Suppl. 1, S73–S90.
41Wollowski, I, Rechkemmer, G & Pool-Zobel, BL (2001) Protective role of probiotics and prebiotics in colon cancer. Am J Clin Nutr 73, 451S–455S.
42Gibson, GR & Wang, X (1994) Regulatory effects of bifidobacteria on the growth of other colonic bacteria. J Appl Bacteriol 77, 412–420.
43Wong, JM, de Souza, R, Kendall, CW, et al. (2006) Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol 40, 235–243.
44Delzenne, NM & Cani, PD (2010) Nutritional modulation of gut microbiota in the context of obesity and insulin resistance: potential interest of prebiotics. Int Dairy J 20, 277–280.
45Cani, PD & Delzenne, NM (2009) Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota. Curr Opin Pharmacol 9, 737–743.
46Van Dokkum, W, Wezendonk, B, Srikumar, TS, et al. (1999) Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young healthy male subjects. Eur J Clin Nutr 53, 1–7.
47Buddington, RK, Williams, CH, Chen, SC, et al. (1996) Dietary supplement of neosugar alters the fecal flora and decreases activities of some reductive enzymes in human subjects. Am J Clin Nutr 63, 709–716.
48Kleessen, B, Sykura, B, Zunft, HJ, et al. (1997) Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons. Am J Clin Nutr 65, 1397–1402.
49Bouhnik, Y, Flourié, B & Riottot, M (1996) Effects of fructo-oligosaccharides ingestion on fecal bifidobacteria and selected metabolic indexes of colon carcinogenesis in healthy humans. Nutr Cancer 26, 21–29.
50Dabek, M, McCrae, SI, Stevens, VJ, et al. (2008) Distribution of beta-glucosidase and beta-glucuronidase activity and of beta-glucuronidase gene gus in human colonic bacteria. FEMS Microbiol Ecol 66, 487–495.
51Van Nuenen, M, Meyer, D & Venema, K (2003) The effect of various inulins and Clostridium difficile on the metabolic activity of the human colonic microbiote in vitro. Microb Ecol Health Dis 15, 137–144.
52Gibson, GR & Macfarlane, GT (1995) Human colonic bacteria: role in nutrition, physiology and pathology. In Human Colonic Bacteria: Role in Nutrition, Physiology and Pathology, pp. 75–100 [, editors]. Boca Raton, FL: CRC Press.
53Bruhwyler, J, Carreer, F, Demanet, E, et al. (2008) Digestive tolerance of inulin-type fructans: a double-blind, placebo-controlled, cross-over, dose-ranging, randomized study in healthy volunteers. Int J Food Sci Nutr 12, 1–11.
54Bakker-Zierikzee, AM, Tol, EA, Kroes, H, et al. (2006) Faecal SIgA secretion in infants fed on pre- or probiotic infant formula. Pediatr Allergy Immunol 17, 134–140.
55Turnbaugh, PJ, Ley, RE, Mahowald, MA, et al. (2006) An obesity associated gut microbiome with increased capacity for every harvest. Nature 444, 1027–1031.
56Cani, P, Amar, J, Iglesias, MA, et al. (2007) Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56, 1761–1772.
57Roller, M, Pietro Femia, A, Caderni, G, et al. (2004) Intestinal immunity of rats with colon cancer is modulated by oligofructose-enriched inulin combined with Lactobacillus rhamnosus and Bifidobacterium lactis. Br J Nutr 92, 931–938.
58Amar, J, Burcelin, R, Ruidavets, JB, et al. (2008) Energy intake is associated with endotoxemia in apparently healthy men. Am J Clin Nutr 87, 1219–1923.
59Ghanim, H, Abuaysheh, S, Sia, CL, et al. (2009) Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for inulin resistance. Diabetes Care 32, 2281–2287.
60Volman, JJ, Mensink, RP, van Griensven, LJ, et al. (2010) Effects of alpha-glucans from Agaricus bisporus on ex vivo cytokine production by LPS and PHA-stimulated PBMCs, a placebo-controlled study in slightly hypercholesterolemic subjects. Eur J Clin Nutr 64, 720–726.
61Hosono, A, Ozawa, A & Kato, R (2003) Dietary fructooligosaccharides induce immunoregulation of intestinal IgA secretion by murine Peyer's patch cells. Biosci Biotechnol Biochem 67, 758–764.
62Roller, M, Rechkemmer, G & Watzl, B (2004) Prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhammosus and Bifidacterium lactis modulates intestinal immune functions in rats. J Nutr 134, 153–156.
63Vulevic, J, Drakoularakou, A, Yaqoob, P, et al. (2008) Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers. Am J Clin Nutr 88, 1438–1446.
64Langkamp-Henken, B, Wood, SM, Herlinger-Garcia, KA, et al. (2006) Nutritional formula improved immune profiles of seniors living in nursing homes. J Am Geriatr Soc 54, 1861–1870.
65Ghanim, H, Sia, CL, Upadhyay, M, et al. (2010) Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression. Am J Clin Nutr 91, 940–949.
66Alvarez, J, Higgins, PB, Oster, RA, et al. (2009) Fasting and postprandial markers of inflammation in lean and overweight children. Am J Clin Nutr 89, 1138–1144.