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Neuroprotection in Acute Ischemic Stroke: A Brief Review

Published online by Cambridge University Press:  16 September 2021

Alastair M. Buchan
Radcliffe Department of Medicine, University of Oxford, Oxford, UK Corpus Christi College, University of Oxford, Oxford, UK Oxford in Berlin, University of Oxford, Oxford, UK
David M. Pelz*
Departments of Medical Imaging and Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada
Correspondence to: David M. Pelz, University Hospital, London Health Sciences Centre, 339 Windermere Rd., London, ON N6A5A5, Canada. Email:


The goal of effective neuroprotection in acute ischemic stroke remains elusive. Despite decades of experimental preclinical and clinical experience with innumerable agents, no strategy has proven to be beneficial in humans. As endovascular therapies mature and approach the limits of speed and efficacy, neuroprotection will become the next frontier of acute stroke care. This review will briefly summarize the history, preclinical and clinical triumphs and failures, and future directions of cerebral neuroprotection.

Résumé :


Survol de la neuroprotection dans le contexte de l’accident vasculaire cérébral ischémique aigu.

L’efficacité de la neuroprotection dans l’accident vasculaire cérébral (AVC) ischémique aigu s’est montrée jusqu’à maintenant difficile à atteindre. Malgré des décennies de recherche expérimentale préclinique et clinique à l’aide de nombreux agents thérapeutiques, aucune stratégie ne s’est avérée efficace chez l’être humain. À mesure que les traitements endovasculaires progressent et frisent les limites de la rapidité d’intervention et de l’efficacité, la neuroprotection se dresse comme la prochaine frontière à repousser en ce qui concerne les soins de l’AVC aigu. Aussi ferons-nous un bref historique de la neuroprotection cérébrale, de ses victoires et de ses échecs précliniques et cliniques, et présenterons-nous les nouvelles orientations en la matière.

Review Article
© The Author(s), 2021. Published by Cambridge University Press on behalf of The Canadian Journal of Neurological Sciences Inc.

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