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The Ontario Neurodegenerative Disease Research Initiative (ONDRI)

  • Sali M. K. Farhan (a1) (a2), Robert Bartha (a2) (a3), Sandra E. Black (a4) (a5), Dale Corbett (a6), Elizabeth Finger (a7), Morris Freedman (a8) (a9), Barry Greenberg (a10), David A. Grimes (a11), Robert A. Hegele (a1) (a2), Chris Hudson (a12), Peter W. Kleinstiver (a13), Anthony E. Lang (a14), Mario Masellis (a4), William E. McIlroy (a15), Paula M. McLaughlin (a13), Manuel Montero-Odasso (a16), David G. Munoz (a17), Douglas P. Munoz (a18), Stephen Strother (a19), Richard H. Swartz (a20), Sean Symons (a21), Maria Carmela Tartaglia (a22), Lorne Zinman (a4), ONDRI Investigators and Michael J. Strong (a2) (a7)...
Abstract
Abstract

Because individuals develop dementia as a manifestation of neurodegenerative or neurovascular disorder, there is a need to develop reliable approaches to their identification. We are undertaking an observational study (Ontario Neurodegenerative Disease Research Initiative [ONDRI]) that includes genomics, neuroimaging, and assessments of cognition as well as language, speech, gait, retinal imaging, and eye tracking. Disorders studied include Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson’s disease, and vascular cognitive impairment. Data from ONDRI will be collected into the Brain-CODE database to facilitate correlative analysis. ONDRI will provide a repertoire of endophenotyped individuals that will be a unique, publicly available resource.

RÉSUMÉ

L’initiative de recherche sur les maladies neurodégénératives en Ontario. La démence constituant la manifestation d’un trouble neurodégénératif ou neurovasculaire, il importe de mettre au point des approches fiables permettant son identification. Nous somme ainsi en train de mener une étude observationnelle – Initiative de recherche sur les maladies neurodégénératives en Ontario ou « ONDRI » – qui inclut l’analyse du génome, la neuro-imagerie et diverses techniques d’évaluation en lien avec les aspects suivants : la cognition, le langage, la démarche, l’imagerie rétinienne et le suivi du regard. Parmi les affections à l’étude, on peut mentionner la maladie d’Alzheimer, la sclérose latérale amyotrophique, la démence fronto-temporale, la maladie de Parkinson et la déficience cognitive vasculaire. Les données de l’ONDRI seront recueillies à partir de la base de données du Brain-CODE afin de faciliter les analyses de corrélation. De plus, l’ONDRI entend fournir un répertoire des endophénotypes associés aux sujets de recherche, répertoire unique en son genre qui sera accessible au public.

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Copyright
This is an open access article, distributed under the terms of the creative commons attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Corresponding author
Correspondence to: Michael J. Strong, Room C7-120, University Hospital – LHSC, 339 Windermere Road, London, Ontario, N6A 5A5. Email: Michael.Strong@schulich.uwo.ca
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