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Paraneoplastic Sensory Neuronopathy and Spontaneous Regression of Small Cell Lung Cancer

Published online by Cambridge University Press:  02 December 2014

Sharlene Gill
Division of Medical Oncology, British Columbia Cancer Agency, Vancouver BC
Nevin Murray
Division of Medical Oncology, British Columbia Cancer Agency, Vancouver BC
Josep Dalmau
Canada and Department of Neurology, University of Arkansas for Medical, Sciences, Little Rock, Arkansas, USA
Brian Thiessen
Division of Medical Oncology, British Columbia Cancer Agency, Vancouver BC Division of Neurology, Vancouver General Hospital, Vancouver, BC
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Spontaneous tumour regression in small cell lung cancer has previously been suggested in patients with paraneoplastic neurologic syndromes. Rare documentation of this event has occurred in the literature.

Case Report:

The authors report a patient with anti-Hu associated paraneoplastic sensory neuronopathy who had a spontaneous regression of her small cell lung cancer.


This case supports the hypothesis that anti-Hu neurologic syndromes are the consequence of a misdirected immune response to small cell tumours.



Une régression spontanée du cancer du poumon à petites cellules a déjà été observée chez des patients présentant des syndromes neurologiques paranéoplasiques. De rares cas ont été décrits dans la littérature.

Étude de cas:

Les auteurs rapportent le cas d’un patient présentant une neuropathie sensitive paranéoplasique avec anticorps anti-Hu chez qui un cancer du poumon à petites cellules a régressé spontanément.


Ce cas appuie l’hypothèse selon laquelle les syndromes neurologiques anti-Hu sont la conséquence d’une réponse immunitaire aberrante à des tumeurs à petites cellules.

Case Report
Copyright © The Canadian Journal of Neurological 2003


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