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Progress Report on the Canadian Multicentre Trial of Tetrahydroaminoacridine with Lecithin in Alzheimer's Disease

Published online by Cambridge University Press:  18 September 2015

S. Gauthier ,
R. Bouchard ,
Y. Bacher ,
P. Bailey ,
H. Bergman ,
L. Carrier ,
R. Charbonneau ,
M. Clarfield ,
B. Collier  and
D. Dastoor
...Show all authors
S. Gauthier*
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
R. Bouchard
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
Y. Bacher
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
P. Bailey
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
H. Bergman
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
L. Carrier
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
R. Charbonneau
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
M. Clarfield
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
B. Collier
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
D. Dastoor
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
L. Gauthier
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
M. Germain
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
M. Kissel
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
M. Krieger
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
S. Kushnir
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
A. Lamontagne
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
J. Morin
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
N.P.V. Nair
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
L. Neirinck
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
J. Ratner
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
M. St-Martin
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
S. Suissa
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
Y. Tesfaye
Affiliation:
McGill Centre for Studies in Aging and collaborating institutions, Douglas Hospital Research Centre, Hôpital de l'Enfant-Jésus, Hôpital St-Luc, Hôpital Youville, Jewish General Hospital, Maimonides Hospital for the Aged, St-John's Regional Hospital
*
McGill Centre for Studies in Aging, 1650 Cedar Avenue, Montreal, Quebec, Canada H3G 1A4
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Abstract:

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Since the discovery of a significant depletion of acetylcholine in discrete areas of the brain of patients affected by Alzheimer's disease, attempts at symptomatic therapy have concentrated on acetylcholine supplementation, an approach that is based upon the efficacy of dopaminergic supplementation therapy for Parkinson's disease. Choline, then lecithin, used orally, failed to improve symptoms but the hypothesis that long-term choline supplementation might stabilize the course of Alzheimer's disease remains to be tested. Nerve growth factor may also offer that possibility. Bethanechol administered intracerebroventricularly did not help when a fixed dose was used but individual titration of more selective muscarinic agonists may prove more effective. In this article we report that tetrahydroaminoacridine (THA), given together with highly concentrated lecithin, appears to bring improvement in cognition and in functional autonomy using the Mini Mental State and the Rapid Disability Rating Scale-2 respectively, without change in behavior as reflected by the Behave-AD. Double-blind cross-over studies are in progress to establish its efficacy. Improvement in study design and means of assessment of cognition, functional autonomy and behavior have been made possible by these drug trials.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 16 , Issue S4 , November 1989 , pp. 543 - 546
Copyright
Copyright © Canadian Neurological Sciences Federation 1989

References

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