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Pyridoxine Dependent Epilepsy with Iatrogenic Sensory Neuronopathy

Published online by Cambridge University Press:  18 September 2015

Richard S. McLachlan  and
William F. Brown
Richard S. McLachlan*
Affiliation:
Department of Clinical Neurological Sciences, University of Western Ontario, University Hospital, London
William F. Brown
Affiliation:
Department of Clinical Neurological Sciences, University of Western Ontario, University Hospital, London
*
University Hospital, 339 Windermere Road. London, Ontario N6A 5A5
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Abstract:

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An 18-year-old man was treated from birth with chronic high dose pyridoxine (vitamin B6) up to 2000 mg per day for pyridoxine-dependent seizures. Within two years of onset of treatment, he developed a sensory neuropathy which did not progress over the following 16 years. Electrophysiological studies were consistent with a pure sensory neuronopathy expressed as centripetal degeneration of processes of the dorsal root ganglion cells.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 22 , Issue 1 , February 1995 , pp. 50 - 51
Copyright
Copyright © Canadian Neurological Sciences Federation 1995

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