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Variant Alzheimer Disease with Spastic Paraparesis: A Rare Presenilin-1 Mutation

Published online by Cambridge University Press:  02 December 2014

Jacqueline A. Pettersen ,
David G. Patry ,
Peter H. St.George-Hyslop  and
Bernadette Curry
Jacqueline A. Pettersen*
Affiliation:
Department of Medicine (Neurology), University of British Columbia, Vancouver Northern Medical Program, University of Northern British Columbia, Prince George, BC
David G. Patry
Affiliation:
Departments of Clinical Neurosciences and Pathology, University of Calgary, Calgary, AB
Peter H. St.George-Hyslop
Affiliation:
Tanz Centre for Research in Neurodegenerative Diseases, Department of Medicine, University of Toronto, ON, Canada Cambridge Institute for Medical Research, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
Bernadette Curry
Affiliation:
Departments of Clinical Neurosciences and Pathology, University of Calgary, Calgary, AB
*
Northern Medical Program, 3333 University Way, University of Northern British Columbia, Prince George, British Columbia, V2N 4Z9, Canada
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Abstract

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Information

Type
Brief Communications
Information
Canadian Journal of Neurological Sciences , Volume 38 , Issue 4 , July 2011 , pp. 659 - 661
Copyright
Copyright © The Canadian Journal of Neurological 2011

References

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3.O’Riordan, S, McMonagle, P, Janssen, JC, et al.Presenilin-1 mutation (E280G), spastic paraparesis, and cranial white-matter abnormalities. Neurology. 2002;59:1108–10.Google Scholar
4.Jacquemont, M-L, Campion, D, Hahn, V, et al.Spastic paraparesis and atypical dementia caused by PSEN1 mutation (P264L), responsible for Alzheimer’s disease. J Med Genet. 2002;39:e2.Google Scholar
5.Rogaeva, E, Bergeron, C, Sato, C, et al.PS1 Alzheimer’s disease family with spastic paraparesis: The search for a gene modifier. Neurology. 2003;61:1005–7.Google Scholar