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N-terminal pro-B-type natriuretic peptide levels in children: comparison in cardiac and non-cardiac diseases

Published online by Cambridge University Press:  27 February 2020

Hyun Su Kim
Affiliation:
Department of Pediatrics, Keimyung University School of Medicine, Daegu, South Korea
Hee Joung Choi*
Affiliation:
Department of Pediatrics, Keimyung University School of Medicine, Daegu, South Korea
*
Author for Correspondence: Hee Joung Choi, MD, Department of Pediatrics, Keimyung University School of Medicine, 1095 Dalgubeol-daero, Dalseo-gu, Daegu, 42601, South Korea. Tel: +82-53-258-7312. Fax: +82-53-258-7319. E-mail: joung756@dsmc.or.kr

Abstract

Background:

N-terminal pro-B-type natriuretic peptide (NT-proBNP), a well-known marker of cardiac disease, may be elevated in acute infections and other non-cardiac diseases. The aim of this study was to evaluate NT-proBNP levels in cardiac and non-cardiac diseases and found out the patient’s clinical status that affects the NT-proBNP levels.

Methods:

NT-proBNP levels were measured in three groups of children: a cardiac disease group, an infectious disease group, and a non-cardiac, non-infectious disease group.

Result:

In total, 348 children were enrolled, including 134 patients (38.5%) with cardiac disease, 170 patients (48.9%) with infectious disease, and 44 patients (12.6%) with non-cardiac, non-infectious disease. The NT-proBNP level of the cardiac disease group (median: 548 pg/mL; range: 5–35,000 pg/mL) was significantly higher than that of the infectious disease group (median: 193 pg/mL; range: 10–35,000 pg/mL) and the non-cardiac, non-infectious disease group (median: 280 pg/mL; range: 6–35,000 pg/mL). Regarding clinical status, the NT-proBNP levels were significantly higher in patients who needed mechanical ventilation support, oxygen therapy, or inotropic medication or had a change in mental status than in other patients. However, the systemic inflammatory response syndrome and mortality were not related to the NT-proBNP level.

Conclusion:

Among heterogeneous group of children, NT-proBNP level can be a useful marker of cardiac disease. Furthermore, the NT-proBNP levels were related to patients’ clinical deteriorations, such as shock rather than the inflammatory status of patients.

Type
Original Article
Copyright
© The Author(s), 2020. Published by Cambridge University Press

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