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Cardiology in the Young Cardiology in the Young

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Reversal of severe mitral regurgitation by device closure of a large patent ductus arteriosus in a premature infant

Published online by Cambridge University Press:  05 July 2016

Ahmed Kheiwa ,
Robert D. Ross  and
Daisuke Kobayashi
Ahmed Kheiwa
Affiliation:
Division of Pediatric Cardiology, Children’s Hospital of Michigan, Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, United States of America
Robert D. Ross
Affiliation:
Division of Pediatric Cardiology, Children’s Hospital of Michigan, Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, United States of America
Daisuke Kobayashi*
Affiliation:
Division of Pediatric Cardiology, Children’s Hospital of Michigan, Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, United States of America
*
Correspondence to: D. Kobayashi, MD, Division of Pediatric Cardiology, Children’s Hospital of Michigan, Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, MI 48201-2119, United States of America. Tel: +1 313 745 5481; Fax: +1 313 993 0894; E-mail: dkobayas@dmc.org
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Abstract

We report a critically ill premature infant with severe mitral valve regurgitation associated with pulmonary hypertension and a severely dilated left atrium from a large patent ductus arteriosus. The mitral valve regurgitation improved significantly with normalisation of left atrial size 4 weeks after percutaneous closure of the patent ductus arteriosus. This case highlights the potential reversibility of severe mitral valve regurgitation with treatment of an underlying cardiac shunt.

Keywords

Patent ductus arteriosusmitral valve regurgitationprematurity
Type
Brief Report
Information
Cardiology in the Young , Volume 27 , Issue 1 , January 2017 , pp. 189 - 192
Copyright
© Cambridge University Press 2016 

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References

1. Alvarez, A, Borgia, F, Guccione, P. Regression of left ventricular dilation after percutaneous closure of a large intralobar pulmonary sequestration. Cardiol Young 2010; 20: 89–90.CrossRefGoogle ScholarPubMed
2. Takahashi, Y, Harada, K, Ishida, A, Tamura, M, Tanaka, T, Takada, G. Changes in left ventricular volume and systolic function before and after the closure of ductus arteriosus in full-term infants. Early Hum Dev 1996; 44: 77–85.CrossRefGoogle ScholarPubMed
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5. Niu, MC, Mallory, GB, Justino, H, et al. Treatment of severe pulmonary hypertension in the setting of the large patent ductus arteriosus. Pediatrics 2013; 131: e1643–e1649.CrossRefGoogle ScholarPubMed
6. Dimas, VV, Takao, C, Ing, FF, et al. Outcomes of transcatheter occlusion of patent ductus arteriosus in infants weighing ≤ 6 kg. JACC Cardiovasc Interv 2010; 3: 1295–1299.CrossRefGoogle Scholar

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