Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 24
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Adjagba, Philippe M. Desjardins, Laurent Fournier, Anne Spigelblatt, Linda Montigny, Martine and Dahdah, Nagib 2015. N-terminal pro-brain natriuretic peptide in acute Kawasaki disease correlates with coronary artery involvement. Cardiology in the Young, Vol. 25, Issue. 07, p. 1311.

    Kim, Jung-Won Gwak, Mijeung Shin, Won-Jung Kim, Hyun-Jung Yu, Jeong Jin and Park, Pyung-Hwan 2015. Preoperative Factors as a Predictor for Early Postoperative Outcomes After Repair of Congenital Transposition of the Great Arteries. Pediatric Cardiology, Vol. 36, Issue. 3, p. 537.

    Nawaytou, Hythem and Bernstein, Harold S 2014. Biomarkers in pediatric heart disease. Biomarkers in Medicine, Vol. 8, Issue. 7, p. 943.

    Kim, So Youn Han, Mi Young Cha, Sung-Ho and Jeon, Yang Bin 2013. N-terminal Pro-Brain Natriuretic Peptide (NT proBNP) as a Predictive Indicator of Initial Intravenous Immunoglobulin Treatment Failure in Children With Kawasaki Disease: A Retrospective Study. Pediatric Cardiology, Vol. 34, Issue. 8, p. 1837.

    Sato, Yuichiro Z. Molkara, Delaram P. Daniels, Lori B. Tremoulet, Adriana H. Shimizu, Chisato Kanegaye, John T. Best, Brookie M. Snider, James V. Frazer, Jeffrey R. Maisel, Alan and Burns, Jane C. 2013. Cardiovascular biomarkers in acute Kawasaki disease. International Journal of Cardiology, Vol. 164, Issue. 1, p. 58.

    Yoshimura, Ken Kimata, Takahisa Mine, Kenji Uchiyama, Takamichi Tsuji, Shoji and Kaneko, Kazunari 2013. N-Terminal Pro-Brain Natriuretic Peptide and Risk of Coronary Artery Lesions and Resistance to Intravenous Immunoglobulin in Kawasaki Disease. The Journal of Pediatrics, Vol. 162, Issue. 6, p. 1205.

    Yu, Jeong Jin 2012. Diagnosis of incomplete Kawasaki disease. Korean Journal of Pediatrics, Vol. 55, Issue. 3, p. 83.

    Bang, Sunhee Yu, Jeong Jin Han, Myung-Ki Ko, Hong Ki Chun, Sail Choi, Hyung Soon Kim, Young-Hwue Ko, Jae-Kon and Park, In-Sook 2011. Log-transformed plasma level of brain natriuretic peptide during the acute phase of Kawasaki disease is quantitatively associated with myocardial dysfunction. Korean Journal of Pediatrics, Vol. 54, Issue. 8, p. 340.

    Kaneko, Kazunari Yoshimura, Ken Ohashi, Atsushi Kimata, Takahisa Shimo, Tomohiko and Tsuji, Shoji 2011. Prediction of the Risk of Coronary Arterial Lesions in Kawasaki Disease by Brain Natriuretic Peptide. Pediatric Cardiology, Vol. 32, Issue. 8, p. 1106.

    Selamet Tierney, Elif Seda Newburger, Jane W. Graham, Dionne Baker, Annette Fulton, David R. and Colan, Steven D. 2011. Diastolic function in children with Kawasaki Disease. International Journal of Cardiology, Vol. 148, Issue. 3, p. 309.

    Das, Bibhuti B. 2010. Plasma B-Type Natriuretic Peptides in Children With Cardiovascular Diseases. Pediatric Cardiology, Vol. 31, Issue. 8, p. 1135.

    Dahdah, Nagib Siles, Ana Fournier, Anne Cousineau, Jocelyne Delvin, Edgard Saint-Cyr, Claire Spiegelblatt, Linda Bonny, Yvette Vartian, Michèle and Montigny, Martine 2009. Natriuretic Peptide as an Adjunctive Diagnostic Test in the Acute Phase of Kawasaki Disease. Pediatric Cardiology, Vol. 30, Issue. 6, p. 810.

    Cantinotti, Massimiliano Clerico, Aldo Murzi, Michele Vittorini, Simona and Emdin, Michele 2008. Clinical relevance of measurement of brain natriuretic peptide and N-terminal pro-brain natriuretic peptide in pediatric cardiology. Clinica Chimica Acta, Vol. 390, Issue. 1-2, p. 12.

    Knazik, Stephen R. and Reisdorff, Earl J. 2008. Pediatric Emergency Medicine.

    Sharieff, Ghazala Q. and Wylie, Todd 2008. Pediatric Emergency Medicine.

    Spirko, Blake and Brewer, Allison V. 2008. Pediatric Emergency Medicine.

    Zakynthinos, Epaminondas Kiropoulos, Theodoros Gourgoulianis, Konstantinos and Filippatos, Gerasimos 2008. Diagnostic and prognostic impact of brain natriuretic peptide in cardiac and noncardiac diseases. Heart & Lung: The Journal of Acute and Critical Care, Vol. 37, Issue. 4, p. 275.

    Takeuchi, Daiji Saji, Tsutomu Takatsuki, Shinichi and Fujiwara, Maya 2007. Abnormal Tissue Doppler Images are Associated With Elevated Plasma Brain Natriuretic Peptide and Increased Oxidative Stress in Acute Kawasaki Disease. Circulation Journal, Vol. 71, Issue. 3, p. 357.

    Lee, Hyunju Kim, Heejung Kim, Hae Soon and Sohn, Sejung 2006. NT-pro BNP : A new diagnostic screening tool for Kawasaki disease. Korean Journal of Pediatrics, Vol. 49, Issue. 5, p. 539.

    Shih, Chie-Youn Sapru, Anil Oishi, Peter Azakie, Anthony Karl, Tom R. Harmon, Cynthia Asija, Ritu Adatia, Ian and Fineman, Jeffrey R. 2006. Alterations in plasma B-type natriuretic peptide levels after repair of congenital heart defects: A potential perioperative marker. The Journal of Thoracic and Cardiovascular Surgery, Vol. 131, Issue. 3, p. 632.


Brain natriuretic peptide can be a useful biochemical marker for myocarditis in patients with Kawasaki disease

  • Takashi Kawamura (a1) and Masakuni Wago (a1)
  • DOI:
  • Published online: 15 August 2006

So as to determine the value of brain natriuretic peptide in the plasma as a biochemical marker for myocarditis of Kawasaki disease, we studied 69 patients. The blood samples, electrocardiograms and cross-sectional echocardiograms were obtained before the commencement of treatment and in the convalescent phase. Results: The mean concentration of brain natriuretic peptide in the plasma was 73.2 ± 107.7 (mean ± SD) pg/ml in the acute phase, and 7.9 ± 7.5 pg/ml in the convalescent phase. We checked the electrocardiograms to find abnormal Q waves, elevation or depression of the ST segments, change in the pattern of the QRS complexes, and flattening or inversion of the T wave, all believed to be markers of myocarditis in Kawasaki disease. Those in whom the concentrations were greater than 50 pg/ml in the acute phase showed abnormal electrocardiograms more frequently than did those in whom the values were less than 50 pg/ml (21/29 vs 3/40, p < 0.0001 odds ratio 32.4). Amplitudes of the T wave in standard limb leads were measured both in the acute and convalescent phases, and the differences calculated. We regarded the sum total of these differences as representing “flattening T wave”, and we named this variable as the total suppressed T wave voltage. We examined the correlation between the variable and the levels of brain natriuretic peptide in the plasma during the acute phase, demonstrating a significant correlation (r = 0.500, p < 0.0001). We conclude, therefore, that the concentration of brain natriuretic peptide measured in the plasma can be a useful biochemical marker for the myocarditis of Kawasaki disease. When the titer is over 50 pg/ml, the patient probably has an abnormal electrocardiogram and is most likely to have myocarditis.

Corresponding author
Correspondence to: Takashi Kawamura MD, Department of Pediatrics, Hiroshima City Asa Hospital 2 chome 1 – 1 Kabeminami, Hiroshima city, 731-0223, Japan. Tel: 81 82 815 5211; Fax: 81 82 814 1791; E-mail:
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Cardiology in the Young
  • ISSN: 1047-9511
  • EISSN: 1467-1107
  • URL: /core/journals/cardiology-in-the-young
Please enter your name
Please enter a valid email address
Who would you like to send this to? *