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    Rahkonen, Otto P. Lee, Kyong-Jin Chaturvedi, Rajiv C. and Benson, Lee N. 2015. The First Ten of Everything: A Review of Past and Current Practice in Pediatric Cardiac Percutaneous Interventions. Congenital Heart Disease, Vol. 10, Issue. 4, p. 292.
    Wang, Yibin Hua, Yimin Li, Li Wang, Xiaoqin Qiao, Lina Shi, Xiaoqing Hua, Jiping Qu, Yi and Mu, Dezhi 2014. Risk Factors and Prognosis of Atrioventricular Block After Atrial Septum Defect Closure Using the Amplatzer Device. Pediatric Cardiology, Vol. 35, Issue. 3, p. 550.
    Geva, Tal Martins, Jose D and Wald, Rachel M 2014. Atrial septal defects. The Lancet, Vol. 383, Issue. 9932, p. 1921.
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Device closure of atrial septal defect: medium-term outcome with special reference to complications

  • Masood Sadiq (a1), Tehmina Kazmi (a1), Asif U. Rehman (a2), Farhan Latif (a2), Najam Hyder (a1) and Shakeel A. Qureshi (a3)...
Abstract
Background

There are concerns over the outcome of device closure of secundum atrial septal defect with special reference to erosions and aortic regurgitation.

Aim

To assess the medium-term outcome of device closure of atrial septal defects with special reference to complications.

Methods

A total of 205 patients with secundum atrial septal defects underwent transcatheter closure from October, 1999 to April, 2009. The median age was 18 (1.4–55) years. Amplatzer Septal Occluder was used in all the patients. Medium-term follow-up was available in 176 of 200 (88%) patients.

Results

Device closure was successful in 200 out of 205 (98%) patients. The device embolised in four patients and was associated with short inferior caval vein margin (p = 0.003). Balloon sizing in 71 patients (35%) resulted in implantation of a larger device (p = 0.002). Early complications included pericardial effusion, 2:1 heart block, and infective endocarditis (1 patient each). There were eight patients who reported migraine (3.9%). At median follow-up of 5.8 (0.6–10.3) years, complete closure occurred in 197 out of 200 patients. Short superior caval vein margin was associated with a residual shunt (p < 0.001). There were two patients who developed mild aortic regurgitation (1%), which correlated with a device-to-defect ratio of >1.3:1 (p = 0.001). There were no erosions, late embolisation, or thromboembolism. Atrial fibrillation occurred in three adults (1.5%).

Conclusions

Device closure of secundum atrial septal defects using Amplatzer Septal Occluder is safe and effective in the medium term. Short inferior caval vein margin correlates with increased risk of embolisation and short superior caval vein margin with a residual shunt. The risk of developing aortic regurgitation is low and correlates with increased device-to-defect ratio.

Copyright
COPYRIGHT: © Cambridge University Press 2011
Corresponding author
Correspondence to: Professor Dr Masood Sadiq, FRCPCH, FRCP(Ed), Head Department of Paediatric Cardiology, The Children's Hospital and Institute of Child Health, Ferozepur Road, Lahore, Pakistan. Tel: 0092-42-99231723; Fax: 0092-42-99230358; E-mail: drmasoodsadiq@hotmail.com
References
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Cardiology in the Young
  • ISSN: 1047-9511
  • EISSN: 1467-1107
  • URL: /core/journals/cardiology-in-the-young
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