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13th Annual C. Walton Lillehei Memorial Lecture – Invisible problems in cardiovascular surgery: What we can learn from prospective observational studies?*

  • James S. Tweddell (a1)
Corresponding author
Correspondence to: Dr J. S. Tweddell, MD, The Division of Cardiothoracic Surgery, Department of Surgery, Medical College of Wisconsin and the Herma Heart Center, Children's Hospital of Wisconsin, 900 W. Wisconsin Avenue, Milwaukee, Wisconsin 53226, United States of America; E-mail:
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Presented at: The Children's Hospital of Philadelphia Cardiology 2012, 16th Annual Update on Pediatric and Congenital Cardiovascular Disease, Orlando, Florida, February 22–26, 2012.

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1.JS Tweddell , GM Hoffman , RT Fedderly , et al. Phenoxybenzamine improves systemic oxygen delivery after the Norwood procedure. Ann Thorac Surg 1999; 67: 161167; discussion 167–168.

3.GM Hoffman , JS Tweddell , NS Ghanayem , et al. Alteration of the critical arteriovenous oxygen saturation relationship by sustained afterload reduction after the Norwood procedure. J Thorac Cardiovasc Surg 2004; 127: 738745.

4.JS Tweddell , NS Ghanayem , KA Mussatto , et al. Mixed venous oxygen saturation monitoring after stage 1 palliation for hypoplastic left heart syndrome. Ann Thorac Surg 2007; 84: 13011310; discussion 1310–1301.

5.GM Hoffman , KA Mussatto , CL Brosig , et al. Systemic venous oxygen saturation after the Norwood procedure and childhood neurodevelopmental outcome. J Thorac Cardiovasc Surg 2005; 130: 10941100.

6.NS Ghanayem , GM Hoffman , KA Mussatto , et al. Perioperative monitoring in high-risk infants after stage 1 palliation of univentricular congenital heart disease. J Thorac Cardiovasc Surg 2010; 140: 857863.

7.GM Hoffman , NS Ghanayem , JM Kampine , et al. Venous saturation and the anaerobic threshold in neonates after the Norwood procedure for hypoplastic left heart syndrome. Ann Thorac Surg 2000; 70: 15151520; discussion 1521.

12.MJ Stampfer , GA Colditz . Estrogen replacement therapy and coronary heart disease: a quantitative assessment of the epidemiologic evidence. Prev Med 1991; 20: 4763.

13.D Grady , SM Rubin , DB Petitti , et al. Hormone therapy to prevent disease and prolong life in postmenopausal women. Ann Intern Med 1992; 117: 10161037.

14.BM Psaty , SR Heckbert , D Atkins , et al. The risk of myocardial infarction associated with the combined use of estrogens and progestins in postmenopausal women. Arch Intern Med 1994; 154: 13331339.

15.S Sidney , DB Petitti , CP Quesenberry Jr. Myocardial infarction and the use of estrogen and estrogen–progestogen in postmenopausal women. Ann Intern Med 1997; 127: 501508.

16.JA Cauley , SR Cummings , DM Black , SR Mascioli , DG Seeley . Prevalence and determinants of estrogen replacement therapy in elderly women. Am J Obstet Gynecol 1990; 163 (Pt 1): 14381444.

17.E Barrett-Connor . Postmenopausal estrogen and prevention bias. Ann Intern Med 1991; 115: 455456.

18.DB Petitti . Coronary heart disease and estrogen replacement therapy. Can compliance bias explain the results of observational studies? Ann Epidemiol 1994; 4: 115118.

19.V Beral , E Banks , G Reeves . Evidence from randomised trials on the long-term effects of hormone replacement therapy. Lancet 2002; 360: 942944.

21.RG Ohye , LA Sleeper , L Mahony , et al. Comparison of shunt types in the Norwood procedure for single-ventricle lesions. N Engl J Med 2010; 362: 19801992.

22.LJ Addonizio . Pediatric ventricular assist devices – first steps for babies. N Engl J Med 2012; 367: 567568.

23.CS Almond , H Buchholz , P Massicotte , et al. Berlin heart EXCOR pediatric ventricular assist device investigational device exemption study: study design and rationale. Am Heart J 2011; 162: 425435; e426.

25.CD Fraser , RDB Jaquiss , DN Rosenthal , et al. Prospective trial of a pediatric ventricular assist device. N Engl J Med 2012; 367: 532541.

28.A Sedrakyan , T Treasure , JA Elefteriades . Effect of aprotinin on clinical outcomes in coronary artery bypass graft surgery: a systematic review and meta-analysis of randomized clinical trials. J Thorac Cardiovasc Surg 2004; 128: 442448.

29.DT Mangano , IC Tudor , C Dietzel . The risk associated with aprotinin in cardiac surgery. N Engl J Med 2006; 354: 353365.

30.DT Mangano , Y Miao , A Vuylsteke , et al. Mortality associated with aprotinin during 5 years following coronary artery bypass graft surgery. JAMA 2007; 297: 471479.

31.JE Bekelman , Y Li , CP Gross . Scope and impact of financial conflicts of interest in biomedical research: a systematic review. JAMA 2003; 289: 454465.

32.DA Fergusson , PC Hebert , CD Mazer , et al. A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med 2008; 358: 23192331.

33.K Benson , AJ Hartz . A comparison of observational studies and randomized, controlled trials. N Engl J Med 2000; 342: 18781886.

34.J Concato , N Shah , RI Horwitz . Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med 2000; 342: 18871892.

35.JP Ioannidis , AB Haidich , M Pappa , et al. Comparison of evidence of treatment effects in randomized and nonrandomized studies. JAMA 2001; 286: 821830.

36.P Tricoci , JM Allen , JM Kramer , RM Califf , SC Smith Jr. Scientific evidence underlying the ACC/AHA clinical practice guidelines. JAMA 2009; 301: 831841.

37.BG Hammill , AF Hernandez , ED Peterson , GC Fonarow , KA Schulman , LH Curtis . Linking inpatient clinical registry data to Medicare claims data using indirect identifiers. Am Heart J 2009; 157: 9951000.

38.RS Dokholyan , LH Muhlbaier , JM Falletta , et al. Regulatory and ethical considerations for linking clinical and administrative databases. Am Heart J 2009; 157: 971982.

39.AF Hernandez , BG Hammill , ED Peterson , et al. Relationships between emerging measures of heart failure processes of care and clinical outcomes. Am Heart J 2010; 159: 406413.

40.SK Pasquali , JP Jacobs , GJ Shook , et al. Linking clinical registry data with administrative data using indirect identifiers: implementation and validation in the congenital heart surgery population. Am Heart J 2010; 160: 10991104.

41.SK Pasquali , JS Li , X He , et al. Comparative analysis of antifibrinolytic medications in pediatric heart surgery. J Thorac Cardiovasc Surg 2012; 143: 550557.

42.JR Kaltman , DB Andropoulos , PA Checchia , et al. Report of the Pediatric Heart Network and National Heart, Lung, and Blood Institute Working Group on the perioperative management of congenital heart disease. Circulation 2010; 121: 27662772.

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Cardiology in the Young
  • ISSN: 1047-9511
  • EISSN: 1467-1107
  • URL: /core/journals/cardiology-in-the-young
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