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    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Cashen, Katherine Hollis, Taemyn K. Delius, Ralph E. and Meert, Kathleen L. 2016. Extracorporeal Membrane Oxygenation for Pediatric Cardiac Failure: Review with a Focus on Unique Subgroups. Progress in Pediatric Cardiology,


    Dalton, Heidi J. and Macrae, Duncan J. 2015. Extracorporeal Support in Children With Pediatric Acute Respiratory Distress Syndrome. Pediatric Critical Care Medicine, Vol. 16, p. S111.


    Shankarraman, Venkat Kocyildirim, Ergin Olia, Salim E. Kameneva, Marina V. Dzadony, Ryan J. Maul, Timothy M. Simon, Marc A. Champion, Hunter C. Wagner, William R. and Bermudez, Christian A. 2014. Biocompatibility Assessment of the CentriMag-Novalung Adult ECMO Circuit in a Model of Acute Pulmonary Hypertension. ASAIO Journal, Vol. 60, Issue. 4, p. 429.


    Michiels, Erica A. Dumas, Florence Quan, Linda Selby, Leah Copass, Michael and Rea, Thomas 2013. Long-Term Outcomes Following Pediatric Out-of-Hospital Cardiac Arrest*. Pediatric Critical Care Medicine, Vol. 14, Issue. 8, p. 755.


    Mtaweh, Haifa Trakas, Erin V. Su, Erik Carcillo, Joseph A. and Aneja, Rajesh K. 2013. Advances in Monitoring and Management of Shock. Pediatric Clinics of North America, Vol. 60, Issue. 3, p. 641.


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Intermediate-term outcomes after paediatric cardiac extracorporeal membrane oxygenation – what is known (and unknown)

  • John M. Costello (a1), David S. Cooper (a2), Jeffrey P. Jacobs (a2), Paul J. Chai (a2), Roxanne Kirsch (a3), Tami Rosenthal (a3), Heidi J. Dalton (a4), Joseph N. Graziano (a4) and James A. Quintessenza (a2)
  • DOI: http://dx.doi.org/10.1017/S1047951111001697
  • Published online: 13 December 2011
Abstract
Abstract

The use of extracorporeal membrane oxygenation in infants and children with cardiac disease who develop refractory cardiogenic shock, cyanosis, or cardiac arrest is increasing. Early mortality in children with cardiac disease who require extracorporeal membrane oxygenation remains an important issue, as only 40% of cannulated patients survive to discharge from the hospital. However, it is encouraging that 90% children who are discharged alive from the hospital after extracorporeal membrane oxygenation are still alive at intermediate-term follow-up. Surviving patients are at risk for long-term dysfunction of multiple organ systems related to their underlying cardiac disease, non-cardiac comorbidities, treatment-related complications, and exposure to extracorporeal membrane oxygenation. Among the most important acute complications related to support with extracorporeal membrane oxygenation is injury to the central nervous system, which may contribute to adverse neurodevelopmental outcomes. All of these factors, in turn, influence quality of life. Many survivors remain medically complex related to their underlying cardiac disease, comorbidities, and sequelae of complications acquired over their lifetime. Neurological morbidity clearly plays an important role in approximately one-third of survivors, with significant deficits in approximately 10%. The limited data about quality of life data that are available for survivors of cardiac extracorporeal membrane oxygenation suggests that approximately 15–30% of survivors have at least moderately decreased quality of life. Overall, published data support the ongoing use of support with extracorporeal membrane oxygenation in children with acute cardiac failure, most of whom would die without it. However, programmatic efforts to improve the selection of patients and the preservation of the function of end organs during extracorporeal membrane oxygenation are clearly needed in order to improve long-term outcomes.

Copyright
Corresponding author
Correspondence to: Dr J. M. Costello, MD, MPH, Director, Regenstein Cardiac Care Unit, Division of Cardiology, Children's Memorial Hospital, 2300 Children's Plaza, Box 21, Chicago, Illinois 60614, United States of America. Tel: +1 773 880 3099; Fax: +1 773 880 8111; E-mail: jmcostello@childrensmemorial.org
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Cardiology in the Young
  • ISSN: 1047-9511
  • EISSN: 1467-1107
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