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Left ventricular mass by echocardiographic measures in children and adolescents

Published online by Cambridge University Press:  20 November 2012

Sudhir K. Mehta
Sudhir K. Mehta*
Affiliation:
Department of Pediatric Cardiology, Cleveland Clinic Children's Hospital, Cleveland, Ohio, United States of America Heart and Vascular Center, Fairview Hospital, Cleveland Clinic Health System, Cleveland, Ohio, United States of America
*
Correspondence to: Dr S. K. Mehta, MD, MBA, Chairman of Pediatrics, Fairview Hospital, 18101 Lorain Avenue, Cleveland, Ohio 44111-5656, United States of America. Tel: 216 476 7236; Fax: 216 476 7021; E-mail: kemeht@ccf.org
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Abstract

Background

Recent evidence in adults suggests that left ventricular mass measured as left ventricular mass/height1.7 predicts cardiovascular morbidity and mortality better than the two widely used indices, left ventricular mass/body surface area and left ventricular mass/height2.7. Standards of left ventricular mass/height1.7 have not been reported in children, for whom, owing to lack of significant cardiovascular morbidity and mortality, body mass index has traditionally been used as a potential cardiovascular risk factor.

Methods

In this retrospective study, 692 clinically normal children aged 1 day to 18 years underwent detailed echocardiographic assessment to assess whether any of the left ventricular mass indices – left ventricular mass/height1.7, left ventricular mass/body surface area, and left ventricular mass/height2.7 – are associated with obesity as measured by body mass index. Correlations, t-tests, and linear regressions were used for statistical testing.

Results

Left ventricular mass/height1.7 was better correlated (R2 = 0.36) with body mass index than left ventricular mass/body surface area (R2 = 0.179) and left ventricular mass/height2.7 (R2 = 0.006), although all three dependent variables show a significant correlation (p < 0.035). In addition, a higher percentage of obese patients were noted to have elevated left ventricular mass as measured by left ventricular mass/height1.7 than by the other two methods.

Conclusions

Left ventricular mass/height1.7 is a reliable indicator of obesity-associated left ventricular hypertrophy. Left ventricular mass/height1.7 can be used conveniently during transitions from youth to adults for long-term follow-up. These findings support the importance of including left ventricular mass/height1.7 in future studies of cardiovascular risks and preventive strategies in children and adolescents.

Keywords

Left ventricular mass index2.7left ventricular mass index1.7left ventricular mass/height2.7left ventricular mass/height1.7
Type
Original Articles
Information
Cardiology in the Young , Volume 23 , Issue 5 , October 2013 , pp. 727 - 737
Copyright
Copyright © Cambridge University Press 2012 

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