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Spontaneous aortic thrombosis in neonates: a case report and review of literature

Published online by Cambridge University Press:  07 January 2020

John P. Mulcaire-Jones Open the ORCID record for John P. Mulcaire-Jones [Opens in a new window] ,
David K. Bailly ,
Deborah U. Frank ,
Anupam R. Verma ,
Bradley J. Barney  and
Heather M. Siefkes Open the ORCID record for Heather M. Siefkes [Opens in a new window]
John P. Mulcaire-Jones*
Affiliation:
Department of Pediatrics, University of Utah, Salt Lake City, UT, USA
David K. Bailly
Affiliation:
Department of Pediatrics, University of Utah, Salt Lake City, UT, USA
Deborah U. Frank
Affiliation:
Department of Pediatrics, University of Virginia, Charlottesville, VA, USA
Anupam R. Verma
Affiliation:
Department of Pediatrics, University of Utah, Salt Lake City, UT, USA
Bradley J. Barney
Affiliation:
Department of Pediatrics, University of Utah, Salt Lake City, UT, USA
Heather M. Siefkes
Affiliation:
Department of Pediatrics, University of California, Davis, Sacramento, CA, USA
*
Author for correspondence: J. P. Mulcaire-Jones, MD, Department of Pediatrics, University of Utah, 81 N Mario Capecchi Drive, Salt Lake City, UT 84113, USA. Tel: +1 801 662 5700; Fax: 801-585-2507; E-mail: john.mulcairejones@hsc.utah.edu
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Abstract

Neonatal aortic thrombosis is a rare occurrence but can be life-threatening. Most aortic thrombosis in neonates is related to umbilical artery catheters. A case of a neonate with a spontaneous aortic thrombosis is described here along with a comprehensive review of the literature for cases of neonatal aortic thrombosis not related to any intravascular device or procedure. The aetiologies of these spontaneous thromboses and the relevance of hypercoagulable disorders are discussed. The cases were analysed for odds of death by treatment method adjusted for era. The reference treatment method was thrombolysis and anticoagulation. No other treatment modality had significantly lower odds than the reference. Surgery alone had higher odds for death than the reference, but this may be confounded by severity of case. The management recommendations for clinicians encountering neonates with spontaneous neonatal aortic thrombosis are discussed.

Keywords

Spontaneous thrombosisaortic thrombosisneonateclot
Type
Original Article
Information
Cardiology in the Young , Volume 30 , Issue 1 , January 2020 , pp. 95 - 99
Copyright
© Cambridge University Press 2020

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