Hostname: page-component-8448b6f56d-c4f8m Total loading time: 0 Render date: 2024-04-23T21:06:34.577Z Has data issue: false hasContentIssue false
  • English
  • Français

What do we know about cognitive functioning in adult congenital heart disease?

Published online by Cambridge University Press:  13 June 2013

Manavi Tyagi ,
Katie Austin ,
Jan Stygall ,
John Deanfield ,
Shay Cullen  and
Stanton P. Newman
Manavi Tyagi
Affiliation:
Centre for Health Services Research, School of Health Sciences, City University London, London, United Kingdom Division of Medicine, University College London (UCL), London, United Kingdom
Katie Austin
Affiliation:
School of Psychology, University of Surrey, London, United Kingdom
Jan Stygall
Affiliation:
Centre for Health Services Research, School of Health Sciences, City University London, London, United Kingdom
John Deanfield
Affiliation:
GUCH Unit, The Heart Hospital, University College of London Hospitals NHS Foundation Trust, London, United Kingdom
Shay Cullen
Affiliation:
GUCH Unit, The Heart Hospital, University College of London Hospitals NHS Foundation Trust, London, United Kingdom
Stanton P. Newman*
Affiliation:
Centre for Health Services Research, School of Health Sciences, City University London, London, United Kingdom Division of Cardiovascular Sciences, University College London (UCL), London, United Kingdom
*
Correspondence to: Prof. S. P. Newman, Centre for Health Services Research, School of Health Sciences, City University London, Northampton Square, London EC1 V 0HB, United Kingdom. Tel: +44 207 040 5767; Fax: +44 207 040 0875; E-mail: Stanton.Newman.1@city.ac.uk
Get access Rights & Permissions [Opens in a new window]

Abstract

With the advent of improved medical and surgical care in congenital heart disease, there has been an increase in the number of patients who survive into adulthood, giving rise to a new patient population ‘Adults with congenital heart disease’. In the past, morbidity and mortality were the primary concerns for this group. However, with improvements in outcome attention has shifted to other factors such as psychosocial and cognitive functioning. This paper reviews the literature on the cognitive functioning in adult congenital heart disease patients. A total of five relevant articles were retrieved via electronic searches of six databases, including MEDLINE, EMBASE, CINAHL, AMED, PsychINFO, and PubMed. The results displayed a consensus on the presence of some cognitive difficulties in adult congenital heart disease patients. The aetiology of cognitive dysfunctions appears to be multifactorial. The literature is limited by the very small number of studies looking at adults with congenital heart disease, with the majority focusing on cognitive functioning among children with congenital heart disease. However, the presence of cognitive dysfunctions and the resulting impact on the patient's day to day lives warrant for a more detailed and prospective research to enhance the understanding of its aetiology and impact.

Keywords

Congenital heart diseasecognitive functioningadults
Type
Review Articles
Information
Cardiology in the Young , Volume 24 , Issue 1 , February 2014 , pp. 13 - 19
Copyright
Copyright © Cambridge University Press 2013 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

*

Manavi Tyagi and Katie Austin are both first authors on this review with a shared first co-authorship.

References

1. Warnes, C. The adult with congenital heart disease born to be bad? J Am Coll Cardiol 2005: 1–8.CrossRefGoogle ScholarPubMed
2. Kenny, D, Stuart, AG. Long-term outcome of the child with congenital heart disease. Paediatr Child Health 2009: 37–42.CrossRefGoogle Scholar
3. Bedard, E, Shore, DF, Gatzoulis, MA. Adult congenital heart disease: a 2008 overview. Br Med Bull 2008: 151–180.CrossRefGoogle Scholar
4. Daliento, L, Mapelli, D, Volpe, B, et al. Measurement of cognitive outcome and quality of life in congenital heart disease. Heart 2006: 569–574.Google Scholar
5. Bellinger, DC, Newburger, JW. Neuropsychological, psychosocial, and quality-of-life outcomes in children and adolescents with congenital heart disease. Prog Pediatr Cardiol 2010: 87–92.Google Scholar
6. Massaro, AN, El-dib, M, Aly, H, et al. Factors associated with adverse neurodevelopmental outcomes in infants with congenital heart disease. Brain Dev 2008: 437–446.Google Scholar
7. Miatton, M, De Wolf, D, Francois, K, Thiery, E, Vingerhoets, G. Neurocognitive consequences of surgically corrected congenital heart defects: a review. Neuropsychol Rev 2006: 65–85.Google Scholar
8. Mahle, WT. Neurologic and cognitive outcomes in children with congenital heart disease. Curr Opin Pediatr 2001: 482–486.CrossRefGoogle ScholarPubMed
9. Karsdorp, PA, Everaerd, W, Kindt, M, et al. Psychological and cognitive functioning in children and adolescents with congenital heart disease: a meta-analysis. J Pediatr Psychol 2007: 527–541.Google Scholar
10. Horner, T, Liberthson, R, Jellinek, MS. Psychosocial profile of adults with complex congenital heart disease. Mayo Clin Proc 2000: 31–36.Google Scholar
11. Mcgrath, E, Wypij, D, Rappaport, L, et al. Prediction of IQ and achievement at age 8 years from neurodevelopmental status at age 1 year in children with D-transposition of the great arteries. Pediatrics 2004: e572–e576.Google Scholar
12. Vingerhoets, G, De Soete, G, Jannes, C. Subjective complaints versus neuropsychological test performance after cardiopulmonary bypass. J Psychosom Res 1995: 843–853.Google Scholar
13. Utens, EM, Verhulst, FC, Erdman, RA, et al. Psychosocial functioning of young adults after surgical correction for congenital heart disease in childhood: a follow-up study. J Psychosom Res 1994: 745–758.CrossRefGoogle ScholarPubMed
14. Utens, EM, Versluis, D, Verhulst, FC, et al. Psychopathology in young adults with congenital heart disease. Follow-up results. Eur Heart J 1998: 647–651.Google Scholar
15. Daliento, L, Mapelli, D, Russo, G, et al. Health related quality of life in adults with repaired tetralogy of Fallot: psychosocial and cognitive outcomes. Heart 2005: 213–218.Google Scholar
16. Wernovsky, G, Stiles, K, Gauvreau, K, et al. Cognitive development after the Fontan operation. Circulation 2000: 883–889.Google Scholar
17. Eide, MG, Skjaerven, R, Irgens, LM. Associations of birth defects with adult intellectual performance, disability and mortality: population-based cohort study. Pediatr Res 2006: 848–853.CrossRefGoogle ScholarPubMed
18. Grech, V, Gatt, M. Syndromes and malformations associated with congenital heart disease in a population-based study. Int J Cardiol 1999: 151–156.Google Scholar
19. Meberg, A, Hals, J, Thaulow, E. Congenital heart defects – chromosomal anomalies, syndromes and extracardiac malformations. Acta Paediatrica 2007: 1142–1145.CrossRefGoogle ScholarPubMed
20. Bellinger, D, Wypij, D, Duplessis, A, et al. Neurodevelopmental status at eight years in children with dextro-transposition of the great arteries: The Boston Circulatory Arrest Trial. J Thorac Cardiovasc Surg 2003: 1385–1396.Google Scholar
21. Wypij, D, Newburger, JW, Rappaport, LA, et al. The effect of duration of deep hypothermic circulatory arrest in infant heart surgery on late neurodevelopment: The Boston Circulatory Arrest Trial. J Thorac Cardiovasc Surg 2003: 1397–1403.Google Scholar
22. Newburger, JW, Silbert, AR, Buckley, LP, et al. Cognitive function and age at repair of transposition of the great arteries in children. N Engl J Med 1984: 1495–1499.Google Scholar
23. Newburger, JW, Wypij, D, Bellinger, DC, et al. Length of stay after infant heart surgery is related to cognitive outcome at age 8 years. J Pediatr 2003: 67–73.Google Scholar
24. Sahu, B, Chauhan, S, Kiran, U, et al. Neuropsychological function in children with cyanotic heart disease undergoing corrective cardiac surgery: effect of two different rewarming strategies. Eur J Cardiothorac Surg 2009: 505–510.Google Scholar