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Rufus of Ephesus (fl. c. a.d. 100) wrote a large body of works on a variety of medical topics. Generally speaking, the Arabic tradition is particularly important for the reconstruction of much of his œuvre. In the present article, I am going to present four new fragments of Rufus’ On Melancholy and a fragment from an otherwise unknown monograph On Preferring Fresh Poppies. These new fragments provide fascinating new insights into Rufus’ approach to recording case histories.