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Prefrontal cortex, dopamine, and jealousy endophenotype

Published online by Cambridge University Press:  30 November 2012

Donatella Marazziti ,
Michele Poletti ,
Liliana Dell'Osso ,
Stefano Baroni  and
Ubaldo Bonuccelli
Donatella Marazziti*
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnology, University of Pisa, Pisa, Italy
Michele Poletti
Affiliation:
Department of Neuroscience, University of Pisa, Pisa, Italy
Liliana Dell'Osso
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnology, University of Pisa, Pisa, Italy
Stefano Baroni
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnology, University of Pisa, Pisa, Italy
Ubaldo Bonuccelli
Affiliation:
Department of Neuroscience, University of Pisa, Pisa, Italy
*
*Address for correspondence: Donatella Marazziti, MD, Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma 67, 56100 Pisa, Italy. (Email dmarazzi@psico.med.unipi.it)
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Abstract

Jealousy is a complex emotion characterized by the perception of a threat of loss of something that the person values, particularly in reference to a relationship with a loved one, which includes affective, cognitive, and behavioral components. Neural systems and cognitive processes underlying jealousy are relatively unclear, and only a few neuroimaging studies have investigated them. The current article discusses recent empirical findings on delusional jealousy, which is the most severe form of this feeling, in neurodegenerative diseases. After reviewing empirical findings on neurological and psychiatric disorders with delusional jealousy, and after considering its high prevalence in patients with Parkinson's disease under dopamine agonist treatment, we propose a core neural network and core cognitive processes at the basis of (delusional) jealousy, characterizing this symptom as possible endophenotype. In any case, empirical investigation of the neural bases of jealousy is just beginning, and further studies are strongly needed to elucidate the biological roots of this complex emotion.

Keywords

Default mode networkdelusiondopamineendophenotypejealousyResearch Domain Criteriareward processingtheory of mind social bondsventromedial prefrontal cortex
Type
Opinion
Information
CNS Spectrums , Volume 18 , Issue 1 , February 2013 , pp. 6 - 14
Copyright
Copyright © Cambridge University Press 2012

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References

1.Van Sommers, P. Jealousy. London: Penguin; 1988.Google Scholar
2.Mullen, PE. Jealousy: the pathology of passion. Br J Psychiatry. 1991; 158: 593–601.Google Scholar
3.Panksepp, J. The evolutionary sources of jealousy: cross-species approaches to fundamental issues. In: Hart SL, Legerstee M, Eds. Handbook of Jealousy: Theory, Research and Multidisciplinary Approaches. West Suzzex, UK: Blackwell Publishing; 2010, pp 101–120.Google Scholar
4.Parrott, WG. The emotional experiences of envy and jealousy. In: Salovey P, ed. The Psychology of Jealousy and Envy. New York: Guilford; 1991: 3–30.Google Scholar
5.Panksepp, J. Neurologizing the psychology of affects: how appraisal-based constructivism and basic-emotion theory can coexist. Perspect Psychol Sci. 2007; 2(3): 281–296.Google Scholar
6.Hart, SL, Legerstee, M, eds. Handbook of Jealousy: Theory, Research and Multidisciplinary Approaches. West Sussex, UK: Blackwell Publishing; 2010.Google Scholar
7.Buss, DM. The Dangerous Passion: Why Jealousy Is as Necessary as Love and Sex. New York: Free Press; 2000.Google Scholar
8.Marazziti, D. E Vissero Sempre Gelosi e Contenti: Come Trasformare un Sentimento Negativo nella Chiave della Felicità. Milan, Italy: Rizzoli Editore; 2008.Google Scholar
9.Sokoloff, B. Jealousy: A Psychological Study. New York: Howell Soskin; 1947.Google Scholar
10.Marazziti, D, Sbrana, A, Rucci, P, etal. Heterogeneity of the jealousy phenomenon in the general population: an Italian study. CNS Spectr. 2010; 15(1): 19–24.Google Scholar
11.Morris, SE, Cuthbert, BN. Research Domain Criteria: cognitive systems, neural circuits and dimensions of behaviour. Dialogues Clin Neurosci. 2012; 14(1): 29–37.Google Scholar
12.Panksepp, J. Emotional endophenotypes in evolutionary psychiatry. Prog Neuropsychopharmacol Biol Psychiatry. 2006; 30(5): 774–784.Google Scholar
13.Robbins, TW, Gillan, CM, Smith, DG, etal. Neurocognitive endophenotypes of impulsivity and compulsivity: towards dimensional psychiatry. Trends Cogn Sci. 2012; 16(1): 81–91.Google Scholar
14.Zucker, NL, Losh, M, Bulik, CM, etal. Anorexia nervosa and autism spectrum disorders: guided investigation of social cognitive endophenotypes. Psychol Bull. 2007; 133(6): 976–1006.Google Scholar
15.Derntl, B, Habel, U. Deficits in social cognition: a marker for psychiatric disorders? Eur Arch Psychiatry Clin Neurosci. 2011; 261(S2): S145–S149.Google Scholar
16.Tarrier, N, Beckett, R, Harwood, S, etal. Morbid jealousy: a review and cognitive behavioral formulation. Br J Psychiatry. 1990; 157: 319–326.Google Scholar
17.Kingham, M, Gordon, H. Aspects of morbid jealousy. Advances in Psychiatric Treatment. 2004; 10: 207–215.Google Scholar
18.Rydell, RJ, Bringle, RG. Differentiating reactive and suspicious jealousy. Soc Behav Pers. 2007; 35(8): 1099–1114.Google Scholar
19.Camicioli, R. Othello syndrome: at the interface of neurology and psychiatry. Nat Rev Neurol. 2011; 7(9): 477–478.Google Scholar
20.Soyka, M, Schmidt, P. Prevalence of delusional jealousy in psychiatric disorders. J Forensic Sci. 2011; 56(2): 450–452.Google Scholar
21.Soyka, M. Prevalence of delusional jealousy in schizophrenia. Psychopathology. 1995; 28(2): 118–120.Google Scholar
22.Michael, A, Mirza, S, Mirza, KA, etal. Morbid jealousy in alcoholism. Br J Psychiatry. 1995; 167(5): 668–672.Google Scholar
23.Ortigue, S, Bianchi-Demicheli, F. Intention, false beliefs, and delusional jealousy: insights into the right hemisphere from neurological patients and neuroimaging studies. Med Sci Monit. 2011; 17(1): RA1–11.Google Scholar
24.Graff-Radford, J, Whitwell, JL, Geda, YE, etal. Clinical and imaging features of Othello's syndrome. Eur J Neurol. 2012; 19(1): 38–46.Google Scholar
25.Poletti, M, Perugi, G, Logi, G , etal. Dopamine agonists and delusion of jealousy in Parkinson's disease: a cross-sectional prevalence study. Mov Disord. DOI: 10.1002/mds 250129.Google Scholar
26.Nagy, H, Levy-Gigi, E, Somlaiu, Z, etal. The effect of dopamine agonists on adaptive and aberrant salience in Parkinson's disease. Neuropsychopharmacology. 2012; 37(4): 950–958.Google Scholar
27.Kapur, S. Psychosis as a state of aberrant salience: a framework linking biology, phenomenology and pharmacology in schizophrenia. Am J Psychiatry. 2003; 160(1): 13–23.Google Scholar
28.Cannas, A, Solla, P, Floris, G, etal. Othello syndrome in Parkinson's disease patients without dementia. Neurologist. 2009; 15(1): 34–36.Google Scholar
29.Graff-Radford, J, Ahlskog, JE, Bower, JH, etal. Dopamine agonists and Othello's syndrome. Parkinsonism Relat Disord. 2010; 16(10): 680–682.Google Scholar
30.Stefanis, N, Bozi, M, Christodoulou, C, etal. Isolated delusional syndrome in Parkinson's disease. Parkinsonism Relat Disord. 2010; 16(8): 550–552.Google Scholar
31.Appelbaum, PS, Clark Robbins, P, Roth, LH, etal. Dimensional approach to delusions: comparison across types and diagnoses. Am J Psychiatry. 1999; 156(12): 1938–1943.Google Scholar
32.Marazziti, D, Akiskal, HS, Rossi, A, etal. Alteration of the platelet serotonin transporter in romantic love. Psychol Med. 1999; 29(3): 741–755.Google Scholar
33.Takahashi, H, Matsumara, M, Yahata, H, etal. Men and women show distinct brain activations during imagery of sexual and emotional infidelity. Neuroimage. 2006; 32(3): 1299–1307.Google Scholar
34.Harmon-Jones, E, Peterson, CK, Harris, CR. Jealousy: novel methods and neural correlates. Emotion. 2009; 9(1): 113–117.Google Scholar
35.Shamay-Tsoory, SG, Tibi-Elhanany, Y, Aharon-Peretz, J. The green-eyed monster and malicious joy: the neuroanatomical bases of envy and gloating (schadenfreude). Brain. 2007; 130(6): 1663–1678.Google Scholar
36.Bartels, A, Zeki, S. The neural correlates of maternal and romantic love. Neuroimage. 2004; 21(3): 1155–1166.Google Scholar
37.Aron, A, Fisher, H, Mashek, DJ, etal. Reward, motivation and emotion systems associated with early stage intense romantic love. J Neurophysiol. 2005; 94(1): 327–337.Google Scholar
38.Fisher, H, Aron, A, Brown, LL. Romantic love: an fMRI study of a neural mechanism for mate choice. J Comp Neurol. 2005; 493(1): 58–62.Google Scholar
39.Beauregard, M, Courtemanche, J, Paquette, V, etal. The neural basis of unconditioned love. Psychiatry Res. 2009; 172(2): 93–98.Google Scholar
40.Xu, X, Aron, A, Brown, L, etal. Reward and motivation systems: a brain mapping study of early-stage intense romantic love in Chinese participants. Hum Brain Mapp. 2011; 32(2): 249–257.Google Scholar
41.Ortigue, S, Bianchi-Demicheli, F, Patel, N, etal. Neuroimaging of love: fMRI meta-analysis evidence toward new perspectives in sexual medicine. J Sex Med. 2010; 7(11): 3541–3552.Google Scholar
42.De Boer, A, van Buel, EM, Ter Horst, GJ. Love is more than just a kiss: a neurobiological perspective on love and affection. Neuroscience. 2012; 201: 114–124.Google Scholar
43.Heaton, JP. Central neuropharmacological agents and mechanisms in erectile dysfunction: the role of dopamine. Neurosci Biobehav Rev. 2000; 24(5): 561–569.Google Scholar
44.Fisher, HF, Aron, A, Brown, LL. Romantic love: a mammalian brain system for mate choice. Philos Trans R Soc Lond B Biol Sci. 2006; 361(1476): 2173–2186.Google Scholar
45.Cacioppo, S, Bianchi-Demicheli, F, Fru, C, etal. The common neural bases between sexual desire and love: a multilevel kernel density fMRI analysis. J Sex Med. 2012; 9(4): 1048–1054.Google Scholar
46.Cools, R. Dopaminergic modulation of cognitive function-implications for L-DOPA treatment in Parkinson's disease. Neurosci Biobehav Rev. 2006; 30(1): 1–23.Google Scholar
47.Poletti, M, Bonuccelli, U. Orbital and ventromedial prefrontal cortex functioning in Parkinson's disease: neuropsychological evidence. Brain Cogn. 2012; 79(1): 23–33.Google Scholar
48.Frank, MJ, Seeberger, LC, O'Reilly, RC. By carrot or by stick: cognitive reinforcement learning in parkinsonism. Science. 2004; 306(5703): 1940–1943.Google Scholar
49.Yin, HH, Knowlton, BJ. The role of the basal ganglia in habit formation. Nat Rev Neurosci. 2006; 7(6): 464–476.Google Scholar
50.Marzinzik, F, Wotka, J, Wahl, M, etal. Modulation of habit formation by levodopa in Parkinson's disease. PloS One. 2011; 6(11): e27695.Google Scholar
51.Aarsland, D, Marsh, L, Schrag, A. Neuropsychiatric symptoms in Parkinson's disease. Mov Disord. 2009; 24(15): 2175–2186.Google Scholar
52.Knipe, MD, Wickremaratchi, MM, Wyatt-Haines, E, etal. Quality of life in young- compared with late-onset Parkinson's disease. Mov Disord. 2011; 26(11): 2011–2018.Google Scholar
53.Bronner, G. Sexual problems in Parkinson's disease: the multidimensional nature of the problem and of the intervention. J Neurol Sci. 2011; 310(1–2): 139–143.Google Scholar
54.Roy, M, Shohamy, D, Wager, TD. Ventromedial prefrontal subcortical systems and the generation of affective meaning. Trends Cogn Sci. 2012; 16(3): 147–156.Google Scholar
55.Andrews-Hanna, JR, Reidler, JS, Sepulcre, J, etal. Functional-anatomic fractionation of the brain's default network. Neuron. 2010; 65(4): 550–562.Google Scholar
56.Howes, OD, Kambeitz, J, Kim, E, etal. The nature of dopamine dysfunction in schizophrenia and what this means for treatment: meta-analysis of imaging studies. Arch Gen Psychiatry. 2012; 69(8): 776–786.Google Scholar
57.Hendler, RA, Ramachandani, VA, Gilman, J, etal. Stimulant and sedative effects of alcohol. Curr Top Behav Neurosci. 2013; 13: 489–509.Google Scholar
58.Rinne, JO, Laine, M, Kaasinen, V, etal. Striatal dopamine transporter and extrapyramidal symptoms in frontotemporal dementia. Neurology. 2002; 58(10): 1489–1493.Google Scholar
59.Reeves, S, Brown, R, Howard, R, etal. Increased striatal dopamine (D2/D3) receptor availability and delusions in Alzheimer's disease. Neurology. 2009; 72(6): 528–534.Google Scholar
60.Klein, JC, Eggers, C, Kalbe, E, etal. Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivo. Neurology. 2010; 74(11): 885–892.Google Scholar
61.Pomarol-Clotet, E, Canales-Rodriguez, EJ, Salvador, R, etal. Medial prefrontal cortex pathology in schizophrenia as revealed by convergent findings from multimodal imaging. Mol Psychiatry. 2010; 15(8): 823–830.Google Scholar
62.Moselhy, HF, Georgiou, G, Kahn, A. Frontal lobe changes in alcoholism: a review of the literature. Alcohol Alcohol. 2001; 36(5): 357–368.Google Scholar
63.Hornberger, M, Geng, J, Hodges, JR. Convergent grey and white matter evidence or orbitofrontal cortex changes related to disinhibition in behavioral variant frontotemporal dementia. Brain. 2011; 134(9): 2502–2512.Google Scholar
64.Harvood, DG, Sultzer, DL, Feil, D, etal. Frontal lobe hypometabolism and impaired insight in Alzheimer's disease. Am J Geriatr Psychiatry. 2005; 13(11): 934–941.Google Scholar
65.Perneczky, R, Drzezga, A, Boecker, H, etal. Right prefrontal hypometabolism predicts delusions in dementia with Lewy bodies. Neurobiol Aging. 2009; 30(9): 1420–1429.Google Scholar
66.Gradin, VB, Kumar, P, Waiter, G, etal. Expected value and prediction error abnormalities in depression and schizophrenia. Brain. 2011; 134(6): 1751–1764.Google Scholar
67.Beck, A, Schlagenhauf, F, Wustenberg, T, etal. Ventral striatal activation during reward anticipation correlates with impulsivity in alcoholics. Biol Psychiatry. 2009; 66(8): 734–742.Google Scholar
68.Gleichgerrcht, E, Ibanez, A, Roca, M, etal. Decision making cognition in neurodegenerative diseases. Nat Rev Neurol. 2010; 6(11): 611–623.Google Scholar
69.Shamay-Tsoory, SG, Aharon-Peretz, J, Levkovitz, Y. The neuroanatomical basis of affective mentalizing in schizophrenia: comparison of patients with schizophrenia and patients with localized prefrontal lesions. Schizophr Res. 2007; 90(1–3): 274–283.Google Scholar
70.Gizewski, ER, Muller, BW, Scherbaum, N, etal. The impact of alcohol dependence on social brain function. Addict Biol. 2012; Epub ahead of print 17 Feb. DOI: 10.1111/J 1369-1600.2012 00932.Google Scholar
71.Poletti, M, Enrici, I, Adenzato, M. Cognitive and affective Theory of Mind in neurodegenerative diseases: neuropsychological, neuroanatomical and neurochemical levels. Neurosci Biobehav Rev. 2012; 36(9): 2147–2164.Google Scholar