Hostname: page-component-76fb5796d-5g6vh Total loading time: 0 Render date: 2024-04-25T22:36:47.089Z Has data issue: false hasContentIssue false
  • English
  • Français

Cavum Septi Pellucidi in First-Episode Patients and Young Relatives at Risk for Schizophrenia

Published online by Cambridge University Press:  07 November 2014

Matcheri S. Keshavan ,
Perambur N. Jayakumar ,
Vaibhav A. Diwadkar  and
Amitabh Singh
Get access Rights & Permissions [Opens in a new window]

Abstract

Studies on schizophrenia (SZ) have documented an increased presence of cavum septi pellucidi (CSP) in individuals suffering from the illness. Moreover, the presence of CSP has been cited in support of the early neurodevelopmental hypothesis in SZ. Our objective was to assess the magnetic resonance imaging (MRI) scans of first-episode patients and healthy controls to evaluate the frequency of CSP. The presence and the size of CSP were visually assessed on the MRI scans of 40 first-episode SZ patients, 19 nonpsychotic child and high-risk adolescent offspring of patients with SZ or schizoaffective disorder, and 59 controls. Our analysis revealed an absence of statistically significant differences in the occurrence of CSP between SZ patients, high-risk subjects, and controls. Even when the analysis was restricted to large CSP, no differences were found. Furthermore, no association between CSP and sex or handedness was observed. The absence of CSP abnormalities in first-episode SZ subjects might indicate that SZ is not characterized by developmentally mediated alterations in CSP. Also, family history of SZ might not increase likelihood for CSP.

Type
Original Research
Information
CNS Spectrums , Volume 7 , Issue 2 , February 2002 , pp. 155 - 158
Copyright
Copyright © Cambridge University Press 2002

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Degreef, G, Bogerts, B, Falkai, P, et al.Increased prevalence of the cavum septum pellucidum in magnetic resonance scans and post-mortem brains of schizophrenic patients. Psychiatry Res. 1992;45:1–13.CrossRefGoogle ScholarPubMed
2.DeLisi, LE, Hoff, AL, Kushner, M, Degreef, G. Increased prevalence of cavum septum pellucidum in schizophrenia. Psychiatry Res. 1993;50:193–199.CrossRefGoogle ScholarPubMed
3.Scott, TF, Price, TR, George, MS, Brillman, J, Rothfus, W. Midline cerebral malformations and schizophrenia. J Neuropsychiatry Clin Neurosci. 1993;5:287–293.Google ScholarPubMed
4.Sarwar, M. The septum pellucidum: normal and abnormal. AJNR Am J Neuroradiol. 1989;10:989–1005.Google ScholarPubMed
5.Bruyn, GW. Agenesis septi pellucidi, cavum septi pellucidi, cavum vergae and cavum veli interpositi. In: Vinken, PF, Bruyn, GW, eds. Handbook of Clinical Neurology. New York, NY: North Holland Publishing Co; 1977:299–336.Google Scholar
6.Shaw, CM, Alvord, EC Jr.Cava septi pellucidi et vergae: their normal and pathological states. Brain. 1969;92:213–223.CrossRefGoogle Scholar
7.Pogue-Geile, MF. The development of liability to schizophrenia: early and late developmental models. In: Walker, EF, ed. Schizophrenia: A Life-Course Developmental Perspective. New York, NY: Academic Press; 1991:277–298.CrossRefGoogle Scholar
8.Weinberger, DR. From neuropathology to neurodevelopment. Lancet. 1995;346:552–557.CrossRefGoogle ScholarPubMed
9.Woods, BT. Is schizophrenia a progressive neurodevelopmental disorder? Toward a unitary pathogenetic mechanism. Am J Psychiatry. 1998;155:1661–1670.CrossRefGoogle Scholar
10.Feinberg, I. Schizophrenia as an emergent disorder of late brain maturation. In: Keshavan, MS, Murray, RM, eds. Neurodevelopment and Adult Psychopathology. Cambridge, UK: Cambridge University Press; 1997:237–252.Google Scholar
11.Razi, K, Greene, KP, Sakuma, M, Ge, S, Kushner, M, DeLisi, LE. Reduction of the parahippocampal gyrus and the hippocampus in patients with chronic schizophrenia. Br J Psychiatry. 1999;174:512–519.CrossRefGoogle ScholarPubMed
12.Keshavan, MS, Bagwell, W, Hass, G, et al.Is there arrested development of the corpus callosum in first-break schizophrenia patients? [abstract]. Biol Psychiatry. 1995;37:653.CrossRefGoogle Scholar
13.DeQuardo, JR, Keshavan, MS, Bookstein, FL, et al.Landmark-based morphometric analysis of first-episode schizophrenia. Biol Psychiatry. 1999;45:1321–1328.CrossRefGoogle ScholarPubMed
14.Tamminga, CA, Thaker, GK, Buchanan, R, et al.Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome. Arch Gen Psychiatry. 1992;49:522–530.CrossRefGoogle ScholarPubMed
15.McCarley, RW, Wible, CG, Frumin, M, et al.MRI anatomy of schizophrenia. Biol Psychiatry. 1999;45:1099–1119.CrossRefGoogle ScholarPubMed
16.Bogerts, B, Lieberman, JA, Ashtari, M, et al.Hippocampus-amygdala volumes and psychopathology in chronic schizophrenia. Biol Psychiatry. 1993;33:236–246.CrossRefGoogle ScholarPubMed
17.Gur, RE, Turetsky, BI, Cowell, PE, et al.Temporolimbic volume reductions in schizophrenia. Arch Gen Psychiatry. 2000;57:769–775.CrossRefGoogle ScholarPubMed
18.Jurjus, GJ, Nasrallah, HA, Olson, SC, Schwarzkopf, SB. Cavum septum pellucidum in schizophrenia, affective disorder and healthy controls: a magnetic resonance imaging study. Psychol Med. 1993;23:319–322.CrossRefGoogle ScholarPubMed
19.Kwon, JS, Shenton, ME, Hirayasu, Y, et al.MRI study of cavum septi pellucidi in schizophrenia, affective disorder, and schizotypal personality disorder. Am J Psychiatry. 1998;155:509–515.CrossRefGoogle ScholarPubMed
20.Shioiri, T, Oshitani, Y, Kato, T, et al.Prevalence of cavum septum pellucidum detected by MRI in patients with bipolar disorder, major depression and schizophrenia. Psychol Med. 1996;26:431–434.CrossRefGoogle ScholarPubMed
21.Hagino, H, Suzuki, M, Kurokawa, K, et al.Magnetic resonance imaging study of the cavum septi pellucidi in patients with schizophrenia. Am J Psychiatry. 2001;158:1717–1719.CrossRefGoogle ScholarPubMed
22.Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.Google Scholar
23.Hollingshead, AB. Four-Factor Index of Social Status. New Haven, Conn: Yale University; 1975.Google Scholar
24.Nopoulos, P, Swayze, V, Flaum, M, et al.Cavum septi pellucidi in normals and patients with schizophrenia as detected by magnetic resonance imaging. Biol Psychiatry. 1997;41:1102–1108.CrossRefGoogle ScholarPubMed
25.Fukuzako, T, Fukuzako, H, Kodama, S, Hashiguchi, T, Takigawa, M. Cavum septum pellucidum in schizophrenia: a magnetic resonance imaging study. Psychiatry Clin Neurosci. 1996;50:125–128.CrossRefGoogle ScholarPubMed
26.Nopoulos, P, Swayze, V, Andreasen, NC. Pattern of brain morphology in patients with schizophrenia and large cavum septi pellucidi. J Neuropsychiatry Clin Neurosci. 1996;8:147–152.Google ScholarPubMed
27.Feinberg, I. Schizophrenia: caused by a fault in programmed synaptic elimination during adolescence? J Psychiatr Res. 1982–1983;17:319–334.CrossRefGoogle ScholarPubMed
28.Keshavan, MS, Anderson, S, Pettegrew, JWIs schizophrenia due to excessive synaptic pruning in the prefrontal cortex? The Feinberg hypothesis revisited. J Psychiatr Res. 1994;28:239–265.CrossRefGoogle ScholarPubMed
29.Benes, FM, Turtle, M, Khan, Y, Farol, P. Myelination of a key relay zone in the hippocampal formation occurs in the human brain during childhood, adolescence, and adulthood. Arch Gen Psychiatry. 1994;51:477–484.CrossRefGoogle ScholarPubMed