Bowers, M.E. and Yehuda, R. 2017. Stress: Neuroendocrinology and Neurobiology.
Birur, Badari Moore, Norman C. and Davis, Lori L. 2016. An Evidence-Based Review of Early Intervention and Prevention of Posttraumatic Stress Disorder. Community Mental Health Journal,
de Quervain, Dominique Schwabe, Lars and Roozendaal, Benno 2016. Stress, glucocorticoids and memory: implications for treating fear-related disorders. Nature Reviews Neuroscience, Vol. 18, Issue. 1, p. 7.
Frijling, Jessie L van Zuiden, Mirjam Koch, Saskia B. J. Nawijn, Laura Veltman, Dick J. and Olff, Miranda 2016. Effects of intranasal oxytocin on amygdala reactivity to emotional faces in recently trauma-exposed individuals. Social Cognitive and Affective Neuroscience, Vol. 11, Issue. 2, p. 327.
Howlett, Jonathon R and Stein, Murray B 2016. Prevention of Trauma and Stressor-Related Disorders: A Review. Neuropsychopharmacology, Vol. 41, Issue. 1, p. 357.
Kapfhammer, Hans-Peter 2016. Psychiatrie, Psychosomatik, Psychotherapie.
Lehrner, Amy Daskalakis, Nicolaos and Yehuda, Rachel 2016. Posttraumatic Stress Disorder.
Qi, Wei Gevonden, Martin and Shalev, Arieh 2016. Prevention of Post-Traumatic Stress Disorder After Trauma: Current Evidence and Future Directions. Current Psychiatry Reports, Vol. 18, Issue. 2,
Rombold, Felicitas Wingenfeld, Katja Renneberg, Babette Schwarzkopf, Friederike Hellmann-Regen, Julian Otte, Christian and Roepke, Stefan 2016. Impact of exogenous cortisol on the formation of intrusive memories in healthy women. Journal of Psychiatric Research, Vol. 83, p. 71.
Steudte-Schmiedgen, Susann Kirschbaum, Clemens Alexander, Nina and Stalder, Tobias 2016. An integrative model linking traumatization, cortisol dysregulation and posttraumatic stress disorder: Insight from recent hair cortisol findings. Neuroscience & Biobehavioral Reviews, Vol. 69, p. 124.
Thomas, Eileen and Stein, Dan J. 2016. Novel pharmacological treatment strategies for posttraumatic stress disorder. Expert Review of Clinical Pharmacology, p. 1.
van Zuiden, Mirjam Frijling, Jessie L. Nawijn, Laura Koch, Saskia B.J. Goslings, J. Carel Luitse, Jan S. Biesheuvel, Tessa H. Honig, Adriaan Veltman, Dick J. and Olff, Miranda 2016. Intranasal Oxytocin to Prevent Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial in Emergency Department Patients. Biological Psychiatry,
Barreiro, Timothy J. and McIntyre-Spatar, Leslie L. 2015. Encyclopedia of Trauma Care.
Luo, Lanlan Chai, Yan Jiang, Rongcai Chen, Xin and Yan, Tao 2015. Cortisol Supplement Combined with Psychotherapy and Citalopram Improves Depression Outcomes in Patients with Hypocortisolism after Traumatic Brain Injury. Aging and Disease, Vol. 6, Issue. 6, p. 418.
Mouthaan, Joanne Sijbrandij, Marit Reitsma, Johannes B. Luitse, Jan S.K. Goslings, J. Carel Gersons, Berthold P.R. and Olff, Miranda 2015. The role of early pharmacotherapy in the development of posttraumatic stress disorder symptoms after traumatic injury: an observational cohort study in consecutive patients. General Hospital Psychiatry, Vol. 37, Issue. 3, p. 230.
Olff, Miranda Van Zuiden, Mirjam and Bakker, Anne 2015. Early interventions: from e-health to neurobiology. European Journal of Psychotraumatology, Vol. 6,
Olff, Miranda 2015. Mobile mental health: a challenging research agenda. European Journal of Psychotraumatology, Vol. 6,
Roque, Autumn Pearl 2015. Pharmacotherapy as Prophylactic Treatment of Post-Traumatic Stress Disorder: A Review of the Literature. Issues in Mental Health Nursing, Vol. 36, Issue. 9, p. 740.
Sijbrandij, Marit Kleiboer, Annet Bisson, Jonathan I Barbui, Corrado and Cuijpers, Pim 2015. Pharmacological prevention of post-traumatic stress disorder and acute stress disorder: a systematic review and meta-analysis. The Lancet Psychiatry, Vol. 2, Issue. 5, p. 413.
Venero, César 2015. Cognitive Enhancement.
Secondary pharmacological interventions have shown promise at reducing the development of posttraumatic stress disorder symptoms (PTSS) in preclinical studies. The present study examined the preliminary efficacy of a 10-day low-dose (20 mg bid) course of hydrocortisone at preventing PTSS in traumatic injury victims.
Sixty-four traumatic injury patients (34% female) were randomly assigned in a double-blind protocol to receive either a 10-day course of hydrocortisone or placebo initiated within 12 hours of the trauma. One-month and 3-months posttrauma participants completed an interview to assess PTSS and self-report measures of depression and health-related quality of life.
Hydrocortisone recipients reported fewer PTSD and depression symptoms, and had greater improvements in health-related quality of life during the first 3 months posttrauma than did placebo recipients. Hydrocortisone recipients who had never received prior mental health treatment had the lowest PTSD scores.
Low-dose hydrocortisone may be a promising approach to the prevention of PTSD in acutely injured trauma patients, and may be particularly efficacious in acutely injured trauma victims without a history of significant psychopathology.
Funding for this study was provided by the National Institute of Mental Health (R34 MH73014) and the Ohio Board of Regents.
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