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Injury Increases the Risk for PTSD: An Examination of Potential Neurobiological and Psychological Mediators

  • Danny Koren, Deborah Hemel and Ehud Klein
Abstract

A growing number of common traumatic events involve both physical and emotional injuries. In contrast to previously held beliefs, the rapidly growing body of literature shows quite convincingly that physical injury, over and above exposure to the traumatic event itself, increases rather than decreases the risk for posttraumatic stress disorder (PTSD). A pertinent question becomes how bodily injury contributes to the risk of developing PTSD. In this article, we review contemporary findings regarding the neurobiological and psychological mechanisms by which bodily injury may augment or independently contribute to chronic posttraumatic stress. In addition, we propose three theoretical pathways through which physical injury can increase the risk for PTSD. These pathways are: additive, unique, and recovery impeding. Finally, we highlight unresolved issues pertaining to each one of these pathways and propose directions for future research to address them.

Copyright
COPYRIGHT: © Cambridge University Press 2006
Corresponding author
Please direct all correspondence to: Danny Koren, PhD, Rambam Medical Center, Department of Psychiatry, Haifa, 31905 Israel; Tel: 972-4-8542559, Fax: 972-4-8543050; E-mail: dkoren@psy.haifa.ac.il.
References
Hide All
1.Allen, JG. Coping with Trauma: A Guide to Self-Understanding. Washington, DC: American Psychiatric Press; 1995.
2.Ulman, RB, Brothers, D. A self-psychological reevaluation of posttraumatic stress disorder (PTSD) and its treatment: shattered fantasies. J Am Acad Psychoanal. 1987;15:175–203.
3.Koren, D, Norman, D, Cohen, A, Berrman, J, Klein, EM. Increased PTSD risk with combat-related injury: a matched comparison study of injured and uninjured soldiers experiencing the same combat events. Am J Psychiatry. 2005;162:276–282.
4.de Kloet, CS, Vermetten, E, Geuze, E, Kavelaars, A, Heijnen, CJ, Westenberg, HG. Assessment of HPA-axis function in posttraumatic stress disorder: pharmacological and non-pharmacological challenge tests, a review. J Psychiatr Res. 2005 Oct 6; [Epub ahead of print].
5.Yehuda, R, Giller, EL, Southwick, SM, Lowy, MT, Mason, JW. Hypothalamic-pituitary-adrenal dysfunction in posttraumatic stress disorder. Biol Psychiatry. 1991;30:1031–1048.
6.Olff, M, Langeland, W, Gersons, BP. The psychobiology of PTSD: coping with trauma. Psychoneuroendocrinology. 2005;30:974–982.
7.Davidson, JR, Stein, DJ, Shalev, AY, Yehuda, R. Posttraumatic stress disorder: acquisition, recognition, course, and treatment. J Neuropsychiatry Clin Neurosci. 2004;16:135–147.
8.Shavit, Y, Weidenfeld, J, DeKeyser, FG, et al.Effects of surgical stress on brain prostaglandin E2 production and on the pituitary-adrenal axis: attenuation by pre-emptive analgesia and by central amygdala lesion. Brain Res. 2005;1047:10–17.
9.Desborough, JP. The stress response to trauma and surgery. Br J Anaesth. 2000;85:109–117.
10.Shalev, AY, Sahar, T, Freedman, S, et al.A prospective study of heart rate response following trauma and the subsequent development of posttraumatic stress disorder. Arch Gen Psychiatry. 1998;55:553–559.
11.Buckley, TC, Kaloupek, DG. A meta-analytic examination of basal cardiovascular activity in posttraumatic stress disorder. Psychosom Med. 2001;63:585–594.
12.Schoenfeld, FB, Marmar, CR, Neylan, TC. Current concepts in pharmacotherapy for posttraumatic stress disorder. Psychiatr Serv. 2004;55:519–531.
13.Yehuda, R, Bryant, R, Marmar, C, Zohar, J. Pathological responses to terrorism. Neuropsychopharmacology. 2005;30:1793–1805.
14.Nguyen, NT, Goldman, CD, Ho, HS, Gosselin, RC, Singh, A, Wolfe, BM. Systemic stress response after laparoscopic and open gastric bypass. J Am Coll Surg. 2002;194:557–566.
15.Kitayama, N, Vaccarino, V, Kutner, M, Weiss, P, Bremner, JD. Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: a meta-analysis. J Affect Disord. 2005;88:79–86.
16.Smith, ME. Bilateral hippocampal volume reduction in adults with post-traumatic stress disorder: a meta-analysis of structural MRI studies. Hippocampus. 2005;15:798–807.
17.Gilbertson, MW, Shenton, ME, Ciszewski, A, et al.Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nat Neurosci. 2002;5:1242–1247.
18.Protopopescu, X, Pan, H, Tuescher, O, et al.Differential time courses and specificity of amygdala activity in posttraumatic stress disorder subjects and normal control subjects. Biol Psychiatry. 2005;57:464–473.
19.Shin, LM, Wright, CI, Cannistraro, PA, et al.A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Arch Gen Psychiatry. 2005;62:273–281.
20.Matsuoka, Y, Yamawaki, S, Inagaki, M, Akechi, T, Uchitomi, Y. A volumetric study of amygdala in cancer survivors with intrusive recollections. Biol Psychiatry. 2003;54:736–743.
21.Narita, M, Kishimoto, Y, Ise, Y, Yajima, Y, Misawa, K, Suzuki, T. Direct evidence for the involvement of the mesolimbic kappa-opioid system in the morphine-induced rewarding effect under an inflammatory pain-like state. Neuropsychopharmacology. 2005;30:111–118.
22.Schinkel, C, Gaertner, A, Zaspel, J, Zedler, S, Faist, E, Schuermann, M. Inflammatory mediators are altered in the acute phase of posttraumatic complex regional pain syndrome. Clin J Pain. 2006;22:235–239.
23.Schreiber, S, Galai-Gat, T. Uncontrolled pain following physical injury as the coretrauma in post-traumatic stress disorder. Pain. 1993;54:107–110.
24.Akil, H, Watson, SJ, Young, E. Endogenous opioids: biology and function. Annu Rev Neurosci. 1983;7:223–255.
25.Siegfried, B, Frischknecht, HR, Nunes de Souza, RL. An ethological model for the study of activation and interaction of pain, memory and defensive systems in the attacked mouse. Role of endogenous opioids. Neurosci Biobehav Rev. 1990;14:481–490.
26.Beecher, H. Pain in men wounded in battle. Ann Surg. 1946;123:96–105.
27.van der Kolk, B, Greenberg, M, Boyd, H, Krystal, J. Inescapable shock, neurotransmitters, and addiction to trauma: toward a psychobiology of post traumatic stress. Biol Psychiatry. 1985;20:314–325.
28.Pitman, RK, van der Kolk, BA, Orr, SP, Greenberg, MS. Naloxone-reversible analgesic response to combat-related stimuli in posttraumatic stress disorder. A pilot study. Arch Gen Psychiatry. 1990;47:541–544.
29.van der Kolk, BA, Greenberg, MS, Orr, SP, Pitman, RK. Endogenous opioids, stress induced analgesia, and posttraumatic stress disorder. Psychopharmacol Bull. 1989;25:417–421.
30.Nishith, P, Griffin, MG, Poth, T. Stress-induced analgesia: prediction of posttraumatic stress symptoms in battered versus nonbattered women. Biol Psychiatry. 2002;51:867–874.
31.Schonenberg, M, Reichwald, U, Domes, G, Badke, A, Hautzinger, M. Effects of peritraumatic ketamine medication on early and sustained posttraumatic stress symptoms in moderately injured accident victims. Psychopharmacology (Berl). 2005;182:420–425.
32.Winter, H, Irle, E. Hippocampal volume in adult burn patients with and without posttraumatic stress disorder. Am J Psychiatry. 2004;161:2194–2200.
33.Raison, CL, Miller, AH. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am J Psychiatry. 2003;160:1554–1565.
34.Maier, SF, Nguyen, KT, Deak, T, Milligan, ED, Watkins, LR. Stress, learned helplessness, and brain interleukin-1 beta. Adv Exp Med Biol. 1999;461:235–249.
35.Reichenberg, A, Yirmiya, R, Schuld, A, et al.Cytokine-associated emotional and cognitive disturbances in humans. Arch Gen Psychiatry. 2001;58:445–452.
36.Krueger, JM, Obal, F Jr, Fang, J. Humoral regulation of physiological sleep: cytokines and GHRH. J Sleep Res. 1999;(8 suppl 1):53–59.
37.Anisman, H, Ravindran, AV, Griffiths, J, Merali, Z. Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical features. Mol Psychiatry. 1999;4:182–188.
38.Larson, SJ, Dunn, AJ. Behavioral effects of cytokines. Brain Behav Immun. 2001;15:371–387.
39.Baker, DG, Ekhator, NN, Kasckow, JW, et al.Plasma and cerebrospinal fluid interleukin-6 concentrations in posttraumatic stress disorder. Neuroimmunomodulation. 2001;9:209–217.
40.Baker, DG, Mendenhall, CL, Simbartl, LA, Magan, LK, Steinberg, JL. Relationship between posttraumatic stress disorder and self-reported physical symptoms in Persian Gulf War veterans. Arch Intern Med. 1997;157:2076–2078.
41.Thombs, BDFJ, McCann, UD. Stress disorders following traumatic injury: assessment and treatment considerations. Primary Psychiatry. 2005;12:51–55.
42.Mellman, TA, Bustamante, V, Fins, AI, Pigeon, WR, Nolan, B. REM sleep and the early development of posttraumatic stress disorder. Am J Psychiatry. 2002;169:1696–1701.
43.Shalev, AY. Posttraumatic stress disorder among injured survivors of a terrorist attack. Predictive value of early intrusion and avoidance symptoms. J Nerv Ment Dis. 1992;180:505–509.
44.Michaels, AJ, Michaels, CE, Moon, CH, et al.Posttraumatic stress disorder after injury: impact on general health outcome and early risk assessment. J Trauma. 1999;47:460–466.
45.Pitman, RK, Altman, B, Macklin, ML. Prevalence of posttraumatic stress disorder in wounded Vietnam veterans. Am J Psychiatry. 1389;146:667–663.
46.Gayle Beck, J, Gudmundsdottir, B, Shipherd, JC. PTSD and emotional distress symptoms measured after a motor vehicle accident: relationships with pain coping profiles. J Psychopathol Behav Assess. 2003;25:219–227.
47.Buchwald, D, Goldberg, J, Noonan, C, Beals, J, Manson, S. Relationship between post-traumatic stress disorder and pain in two American Indian tribes. Pain Med. 2005;6:72–79.
48.Asmundson, GJ, Coons, MJ, Taylor, S, Katz, J. PTSD and the experience of pain: research and clinical implications of shared vulnerability and mutual maintenance models. Can J Psychiatry. 2002;47:930–937.
49.Fukunishi, I. Relationship of cosmetic disfigurement to the severity of posttraumatic stress disorder in burn injury or digital amputation. Psychother Psychosom. 1999;68:82–86.
50.Nemeroff, CB, Bremner, JD, Foa, EB, Mayberg, HS, North, CS, Stein, MB. Posttraumatic stress disorder: a state-of-the-science review. J Psychiatr Res. 2006;40:1–21.
51.Schelling, G, Roozendaal, B, De Quervain, DJ. Can posttraumatic stress disorder be prevented with glucocorticoids? Ann N Y Acad Sci. 2004;1032:158–166.
52.Gil, S, Caspi, Y, Ben-Ari, IZ, Koren, D, Klein, E. Does memory of a traumatic event increase the risk for posttraumatic stress disorder in patients with traumatic brain injury? A prospective study. Am J Psychiatry. 2005;162:963–969.
53.Arnon, I. Development and prevalence of post traumatic stress disorder among vehicle accidents victims [dissertation]. Haifa, Israel: Technion - Israel Institute of Technology; 1997.
54.Schnyder, U, Moergeli, H, Klaghofer, R, Sensky, T, Buchi, S. Does patient cognition predict time off from work after life-threatening accidents? Am J Psychiatry. 2003;160:2025–2031.
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