Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 3
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Hikima, Takuya Garcia-Munoz, Marianela and Arbuthnott, Gordon William 2016. Presynaptic D1 heteroreceptors and mGlu autoreceptors act at individual cortical release sites to modify glutamate release. Brain Research, Vol. 1639, p. 74.


    Sun, Yan Yu, Hongbo Chen, Jie Liang, Jie Lu, Lin Zhou, Xiaolin and Shi, Jie 2016. Neural substrates and behavioral profiles of romantic jealousy and its temporal dynamics. Scientific Reports, Vol. 6, p. 27469.


    Poletti, Michele Lucetti, Claudio Baldacci, Filippo Del Dotto, Paolo and Bonuccelli, Ubaldo 2014. Concomitant development of hypersexuality and delusional jealousy in patients with Parkinson's disease: A case series. Parkinsonism & Related Disorders, Vol. 20, Issue. 11, p. 1290.


    ×

Prefrontal cortex, dopamine, and jealousy endophenotype

  • Donatella Marazziti (a1), Michele Poletti (a2), Liliana Dell'Osso (a1), Stefano Baroni (a1) and Ubaldo Bonuccelli (a2)
  • DOI: http://dx.doi.org/10.1017/S1092852912000740
  • Published online: 30 November 2012
Abstract

Jealousy is a complex emotion characterized by the perception of a threat of loss of something that the person values, particularly in reference to a relationship with a loved one, which includes affective, cognitive, and behavioral components. Neural systems and cognitive processes underlying jealousy are relatively unclear, and only a few neuroimaging studies have investigated them. The current article discusses recent empirical findings on delusional jealousy, which is the most severe form of this feeling, in neurodegenerative diseases. After reviewing empirical findings on neurological and psychiatric disorders with delusional jealousy, and after considering its high prevalence in patients with Parkinson's disease under dopamine agonist treatment, we propose a core neural network and core cognitive processes at the basis of (delusional) jealousy, characterizing this symptom as possible endophenotype. In any case, empirical investigation of the neural bases of jealousy is just beginning, and further studies are strongly needed to elucidate the biological roots of this complex emotion.

Copyright
Corresponding author
*Address for correspondence: Donatella Marazziti, MD, Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma 67, 56100 Pisa, Italy. (Email dmarazzi@psico.med.unipi.it)
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

2.PE Mullen . Jealousy: the pathology of passion. Br J Psychiatry. 1991; 158: 593601.

3.J Panksepp . The evolutionary sources of jealousy: cross-species approaches to fundamental issues. In: Hart SL, Legerstee M, Eds. Handbook of Jealousy: Theory, Research and Multidisciplinary Approaches. West Suzzex, UK: Blackwell Publishing; 2010, pp 101120.

5.J Panksepp . Neurologizing the psychology of affects: how appraisal-based constructivism and basic-emotion theory can coexist. Perspect Psychol Sci. 2007; 2(3): 281296.

6.SL Hart , M Legerstee , eds. Handbook of Jealousy: Theory, Research and Multidisciplinary Approaches. West Sussex, UK: Blackwell Publishing; 2010.

12.J Panksepp . Emotional endophenotypes in evolutionary psychiatry. Prog Neuropsychopharmacol Biol Psychiatry. 2006; 30(5): 774784.

13.TW Robbins , CM Gillan , DG Smith , etal. Neurocognitive endophenotypes of impulsivity and compulsivity: towards dimensional psychiatry. Trends Cogn Sci. 2012; 16(1): 8191.

14.NL Zucker , M Losh , CM Bulik , etal. Anorexia nervosa and autism spectrum disorders: guided investigation of social cognitive endophenotypes. Psychol Bull. 2007; 133(6): 9761006.

15.B Derntl , U Habel . Deficits in social cognition: a marker for psychiatric disorders? Eur Arch Psychiatry Clin Neurosci. 2011; 261(S2): S145S149.

16.N Tarrier , R Beckett , S Harwood , etal. Morbid jealousy: a review and cognitive behavioral formulation. Br J Psychiatry. 1990; 157: 319326.

17.M Kingham , H Gordon . Aspects of morbid jealousy. Advances in Psychiatric Treatment. 2004; 10: 207215.

18.RJ Rydell , RG Bringle . Differentiating reactive and suspicious jealousy. Soc Behav Pers. 2007; 35(8): 10991114.

19.R Camicioli . Othello syndrome: at the interface of neurology and psychiatry. Nat Rev Neurol. 2011; 7(9): 477478.

20.M Soyka , P Schmidt . Prevalence of delusional jealousy in psychiatric disorders. J Forensic Sci. 2011; 56(2): 450452.

21.M Soyka . Prevalence of delusional jealousy in schizophrenia. Psychopathology. 1995; 28(2): 118120.

22.A Michael , S Mirza , KA Mirza , etal. Morbid jealousy in alcoholism. Br J Psychiatry. 1995; 167(5): 668672.

23.S Ortigue , F Bianchi-Demicheli . Intention, false beliefs, and delusional jealousy: insights into the right hemisphere from neurological patients and neuroimaging studies. Med Sci Monit. 2011; 17(1): RA111.

24.J Graff-Radford , JL Whitwell , YE Geda , etal. Clinical and imaging features of Othello's syndrome. Eur J Neurol. 2012; 19(1): 3846.

26.H Nagy , E Levy-Gigi , Z Somlaiu , etal. The effect of dopamine agonists on adaptive and aberrant salience in Parkinson's disease. Neuropsychopharmacology. 2012; 37(4): 950958.

27.S Kapur . Psychosis as a state of aberrant salience: a framework linking biology, phenomenology and pharmacology in schizophrenia. Am J Psychiatry. 2003; 160(1): 1323.

28.A Cannas , P Solla , G Floris , etal. Othello syndrome in Parkinson's disease patients without dementia. Neurologist. 2009; 15(1): 3436.

29.J Graff-Radford , JE Ahlskog , JH Bower , etal. Dopamine agonists and Othello's syndrome. Parkinsonism Relat Disord. 2010; 16(10): 680682.

30.N Stefanis , M Bozi , C Christodoulou , etal. Isolated delusional syndrome in Parkinson's disease. Parkinsonism Relat Disord. 2010; 16(8): 550552.

32.D Marazziti , HS Akiskal , A Rossi , etal. Alteration of the platelet serotonin transporter in romantic love. Psychol Med. 1999; 29(3): 741755.

33.H Takahashi , M Matsumara , H Yahata , etal. Men and women show distinct brain activations during imagery of sexual and emotional infidelity. Neuroimage. 2006; 32(3): 12991307.

34.E Harmon-Jones , CK Peterson , CR Harris . Jealousy: novel methods and neural correlates. Emotion. 2009; 9(1): 113117.

35.SG Shamay-Tsoory , Y Tibi-Elhanany , J Aharon-Peretz . The green-eyed monster and malicious joy: the neuroanatomical bases of envy and gloating (schadenfreude). Brain. 2007; 130(6): 16631678.

36.A Bartels , S Zeki . The neural correlates of maternal and romantic love. Neuroimage. 2004; 21(3): 11551166.

37.A Aron , H Fisher , DJ Mashek , etal. Reward, motivation and emotion systems associated with early stage intense romantic love. J Neurophysiol. 2005; 94(1): 327337.

38.H Fisher , A Aron , LL Brown . Romantic love: an fMRI study of a neural mechanism for mate choice. J Comp Neurol. 2005; 493(1): 5862.

39.M Beauregard , J Courtemanche , V Paquette , etal. The neural basis of unconditioned love. Psychiatry Res. 2009; 172(2): 9398.

40.X Xu , A Aron , L Brown , etal. Reward and motivation systems: a brain mapping study of early-stage intense romantic love in Chinese participants. Hum Brain Mapp. 2011; 32(2): 249257.

41.S Ortigue , F Bianchi-Demicheli , N Patel , etal. Neuroimaging of love: fMRI meta-analysis evidence toward new perspectives in sexual medicine. J Sex Med. 2010; 7(11): 35413552.

42.A De Boer , EM van Buel , GJ Ter Horst . Love is more than just a kiss: a neurobiological perspective on love and affection. Neuroscience. 2012; 201: 114124.

43.JP Heaton . Central neuropharmacological agents and mechanisms in erectile dysfunction: the role of dopamine. Neurosci Biobehav Rev. 2000; 24(5): 561569.

44.HF Fisher , A Aron , LL Brown . Romantic love: a mammalian brain system for mate choice. Philos Trans R Soc Lond B Biol Sci. 2006; 361(1476): 21732186.

45.S Cacioppo , F Bianchi-Demicheli , C Fru , etal. The common neural bases between sexual desire and love: a multilevel kernel density fMRI analysis. J Sex Med. 2012; 9(4): 10481054.

46.R Cools . Dopaminergic modulation of cognitive function-implications for L-DOPA treatment in Parkinson's disease. Neurosci Biobehav Rev. 2006; 30(1): 123.

47.M Poletti , U Bonuccelli . Orbital and ventromedial prefrontal cortex functioning in Parkinson's disease: neuropsychological evidence. Brain Cogn. 2012; 79(1): 2333.

48.MJ Frank , LC Seeberger , RC O'Reilly . By carrot or by stick: cognitive reinforcement learning in parkinsonism. Science. 2004; 306(5703): 19401943.

49.HH Yin , BJ Knowlton . The role of the basal ganglia in habit formation. Nat Rev Neurosci. 2006; 7(6): 464476.

50.F Marzinzik , J Wotka , M Wahl , etal. Modulation of habit formation by levodopa in Parkinson's disease. PloS One. 2011; 6(11): e27695.

51.D Aarsland , L Marsh , A Schrag . Neuropsychiatric symptoms in Parkinson's disease. Mov Disord. 2009; 24(15): 21752186.

52.MD Knipe , MM Wickremaratchi , E Wyatt-Haines , etal. Quality of life in young- compared with late-onset Parkinson's disease. Mov Disord. 2011; 26(11): 20112018.

53.G Bronner . Sexual problems in Parkinson's disease: the multidimensional nature of the problem and of the intervention. J Neurol Sci. 2011; 310(1–2): 139143.

54.M Roy , D Shohamy , TD Wager . Ventromedial prefrontal subcortical systems and the generation of affective meaning. Trends Cogn Sci. 2012; 16(3): 147156.

55.JR Andrews-Hanna , JS Reidler , J Sepulcre , etal. Functional-anatomic fractionation of the brain's default network. Neuron. 2010; 65(4): 550562.

56.OD Howes , J Kambeitz , E Kim , etal. The nature of dopamine dysfunction in schizophrenia and what this means for treatment: meta-analysis of imaging studies. Arch Gen Psychiatry. 2012; 69(8): 776786.

57.RA Hendler , VA Ramachandani , J Gilman , etal. Stimulant and sedative effects of alcohol. Curr Top Behav Neurosci. 2013; 13: 489509.

58.JO Rinne , M Laine , V Kaasinen , etal. Striatal dopamine transporter and extrapyramidal symptoms in frontotemporal dementia. Neurology. 2002; 58(10): 14891493.

59.S Reeves , R Brown , R Howard , etal. Increased striatal dopamine (D2/D3) receptor availability and delusions in Alzheimer's disease. Neurology. 2009; 72(6): 528534.

60.JC Klein , C Eggers , E Kalbe , etal. Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivo. Neurology. 2010; 74(11): 885892.

61.E Pomarol-Clotet , EJ Canales-Rodriguez , R Salvador , etal. Medial prefrontal cortex pathology in schizophrenia as revealed by convergent findings from multimodal imaging. Mol Psychiatry. 2010; 15(8): 823830.

62.HF Moselhy , G Georgiou , A Kahn . Frontal lobe changes in alcoholism: a review of the literature. Alcohol Alcohol. 2001; 36(5): 357368.

63.M Hornberger , J Geng , JR Hodges . Convergent grey and white matter evidence or orbitofrontal cortex changes related to disinhibition in behavioral variant frontotemporal dementia. Brain. 2011; 134(9): 25022512.

64.DG Harvood , DL Sultzer , D Feil , etal. Frontal lobe hypometabolism and impaired insight in Alzheimer's disease. Am J Geriatr Psychiatry. 2005; 13(11): 934941.

65.R Perneczky , A Drzezga , H Boecker , etal. Right prefrontal hypometabolism predicts delusions in dementia with Lewy bodies. Neurobiol Aging. 2009; 30(9): 14201429.

66.VB Gradin , P Kumar , G Waiter , etal. Expected value and prediction error abnormalities in depression and schizophrenia. Brain. 2011; 134(6): 17511764.

67.A Beck , F Schlagenhauf , T Wustenberg , etal. Ventral striatal activation during reward anticipation correlates with impulsivity in alcoholics. Biol Psychiatry. 2009; 66(8): 734742.

68.E Gleichgerrcht , A Ibanez , M Roca , etal. Decision making cognition in neurodegenerative diseases. Nat Rev Neurol. 2010; 6(11): 611623.

69.SG Shamay-Tsoory , J Aharon-Peretz , Y Levkovitz . The neuroanatomical basis of affective mentalizing in schizophrenia: comparison of patients with schizophrenia and patients with localized prefrontal lesions. Schizophr Res. 2007; 90(1–3): 274283.

71.M Poletti , I Enrici , M Adenzato . Cognitive and affective Theory of Mind in neurodegenerative diseases: neuropsychological, neuroanatomical and neurochemical levels. Neurosci Biobehav Rev. 2012; 36(9): 21472164.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

CNS Spectrums
  • ISSN: 1092-8529
  • EISSN: 2165-6509
  • URL: /core/journals/cns-spectrums
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: