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Separation anxiety disorder from the perspective of DSM-5: clinical investigation among subjects with panic disorder and associations with mood disorders spectrum

  • Camilla Gesi (a1), Marianna Abelli (a1), Alessandra Cardini (a1), Lisa Lari (a1), Luca Di Paolo (a1), Derrick Silove (a2) (a3) and Stefano Pini (a1)...

Abstract

Objective/Introduction

High levels of comorbidity between separation anxiety disorder (SEPAD) and panic disorder (PD) have been found in clinical settings. In addition, there is some evidence for a relationship involving bipolar disorder (BD) and combined PD and SEPAD. We aim to investigate the prevalence and correlates of SEPAD among patients with PD and whether the presence of SEPAD is associated with frank diagnoses of mood disorders or with mood spectrum symptoms.

Methods

Adult outpatients (235) with PD were assessed by the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), the Panic Disorder Severity Scale (PDSS), the Structured Clinical Interview for Separation Anxiety Symptoms (SCI-SAS), and the Mood Spectrum Self-Report Instrument (MOODS-SR, lifetime version).

Results

Of ther 235 subjects, 125 (53.2%) were categorized as having SEPAD and 110 (46.8%) as not. Groups did not differ regarding onset of PD, lifetime prevalence of obsessive compulsive disorder (OCD), social phobia, simple phobia, BD I and II, or major depressive disorder (MDD). SEPAD subjects were more likely to be female and younger; they showed higher rates of childhood SEPAD, higher PDSS scores, and higher MOODS-SR total and manic component scores than subjects without SEPAD.

Discussion

SEPAD is highly prevalent among PD subjects. Patients with both PD and SEPAD show higher lifetime mood spectrum symptoms than patients with PD alone. Specifically, SEPAD is correlated with the manic/hypomanic spectrum component.

Conclusion

Our data confirm the high prevalence of SEPAD in clinical settings. Moreover, our findings corroborate a relationship between mood disorders and SEPAD, highlighting a relationship between lifetime mood spectrum symptoms and SEPAD.

Copyright

Corresponding author

*Address for correspondence: Camilla Gesi, Department of Clinical and Experimental Medicine, Psychiatry Sector, University of Pisa, via Roma 67, 56100 Pisa, Italy. (Email: camillagesi@hotmail.com)

Footnotes

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This work was supported by grants from the Italian Ministry of University and Scientific Research (PRIN 2005: prot. 2005069159) and Fondazione IDEA (Institute for Research and Prevention of Depression and Anxiety).

Footnotes

References

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Keywords

Separation anxiety disorder from the perspective of DSM-5: clinical investigation among subjects with panic disorder and associations with mood disorders spectrum

  • Camilla Gesi (a1), Marianna Abelli (a1), Alessandra Cardini (a1), Lisa Lari (a1), Luca Di Paolo (a1), Derrick Silove (a2) (a3) and Stefano Pini (a1)...

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