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Separation anxiety disorder from the perspective of DSM-5: clinical investigation among subjects with panic disorder and associations with mood disorders spectrum

Published online by Cambridge University Press:  23 February 2015

Camilla Gesi ,
Marianna Abelli ,
Alessandra Cardini ,
Lisa Lari ,
Luca Di Paolo ,
Derrick Silove  and
Stefano Pini
Camilla Gesi*
Affiliation:
Department of Clinical and Experimental Medicine, Psychiatry Sector, University of Pisa, Pisa, Italy
Marianna Abelli
Affiliation:
Department of Clinical and Experimental Medicine, Psychiatry Sector, University of Pisa, Pisa, Italy
Alessandra Cardini
Affiliation:
Department of Clinical and Experimental Medicine, Psychiatry Sector, University of Pisa, Pisa, Italy
Lisa Lari
Affiliation:
Department of Clinical and Experimental Medicine, Psychiatry Sector, University of Pisa, Pisa, Italy
Luca Di Paolo
Affiliation:
Department of Clinical and Experimental Medicine, Psychiatry Sector, University of Pisa, Pisa, Italy
Derrick Silove
Affiliation:
Psychiatry Research and Teaching Unit, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia Centre for Population Mental Health Research, South Western Sydney Local Health District, Liverpool Hospital, Sydney, New South Wales, Australia
Stefano Pini
Affiliation:
Department of Clinical and Experimental Medicine, Psychiatry Sector, University of Pisa, Pisa, Italy
*
*Address for correspondence: Camilla Gesi, Department of Clinical and Experimental Medicine, Psychiatry Sector, University of Pisa, via Roma 67, 56100 Pisa, Italy. (Email: camillagesi@hotmail.com)
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Abstract

Objective/Introduction

High levels of comorbidity between separation anxiety disorder (SEPAD) and panic disorder (PD) have been found in clinical settings. In addition, there is some evidence for a relationship involving bipolar disorder (BD) and combined PD and SEPAD. We aim to investigate the prevalence and correlates of SEPAD among patients with PD and whether the presence of SEPAD is associated with frank diagnoses of mood disorders or with mood spectrum symptoms.

Methods

Adult outpatients (235) with PD were assessed by the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), the Panic Disorder Severity Scale (PDSS), the Structured Clinical Interview for Separation Anxiety Symptoms (SCI-SAS), and the Mood Spectrum Self-Report Instrument (MOODS-SR, lifetime version).

Results

Of ther 235 subjects, 125 (53.2%) were categorized as having SEPAD and 110 (46.8%) as not. Groups did not differ regarding onset of PD, lifetime prevalence of obsessive compulsive disorder (OCD), social phobia, simple phobia, BD I and II, or major depressive disorder (MDD). SEPAD subjects were more likely to be female and younger; they showed higher rates of childhood SEPAD, higher PDSS scores, and higher MOODS-SR total and manic component scores than subjects without SEPAD.

Discussion

SEPAD is highly prevalent among PD subjects. Patients with both PD and SEPAD show higher lifetime mood spectrum symptoms than patients with PD alone. Specifically, SEPAD is correlated with the manic/hypomanic spectrum component.

Conclusion

Our data confirm the high prevalence of SEPAD in clinical settings. Moreover, our findings corroborate a relationship between mood disorders and SEPAD, highlighting a relationship between lifetime mood spectrum symptoms and SEPAD.

Keywords

Comorbiditymood disordersmood spectrumpanic disorderseparation anxiety
Type
Original Research
Information
CNS Spectrums , Volume 21 , Issue 1 , February 2016 , pp. 70 - 75
Copyright
© Cambridge University Press 2015 

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Footnotes

This work was supported by grants from the Italian Ministry of University and Scientific Research (PRIN 2005: prot. 2005069159) and Fondazione IDEA (Institute for Research and Prevention of Depression and Anxiety).

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