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1.AJ Thomas , R Perry , R Barber , RR Kalaria , JT O'Brien . Pathologies and pathological mechanisms for white matter hyperintensities in depression. Ann N Y Acad Sci. 2002; 977: 333–339.
2.AJ Thomas , JT O'Brien , S Davis , etal. Ischemic basis for deep white matter hyperintensities in major depression: a neuropathological study. Arch Gen Psychiatry. 2002; 59(9): 785–792.
3.B Ovbiagele , JL Saver . Cerebral white matter hyperintensities on MRI: current concepts and therapeutic implications. Cerebrovasc Dis. 2006; 22(2–3): 83–90.
4.DC Steffens , KR Krishnan . Structural neuroimaging and mood disorders: recent findings, implications for classification, and future directions. Biol Psychiatry. 1998; 43(10): 705–712.
5.P Videbech . MRI findings in patients with affective disorder: a metaanalysis. Acta Psychiatr Scand. 1997; 96(3): 157–168.
6.S Ehrlich , GG Noam , IK Lyoo , etal. White matter hyperintensities and their associations with suicidality in psychiatrically hospitalized children and adolescents. J Am Acad Child Adolesc Psychiatry. 2004; 43(6): 770–776.
7.S Ehrlich , JL Breeze , DC Hesdorffer , etal. White matter hyperintensities and their association with suicidality in depressed young adults. J Affect Disord. 2005; 86(2–3): 281–287.
8.M Pompili , S Ehrlich , E De Pisa , etal. White matter hyperintensities and their associations with suicidality in patients with major affective disorders. Eur Arch Psychiatry Clin Neurosci. 2007; 257(8): 494–499.
9.JC Soares , JJ Mann . The anatomy of mood disorders—review of structural neuroimaging studies. Biol Psychiatry. 1997; 41(1): 86–106.
10.WD Taylor , ME Payne , KR Krishnan , etal. Evidence of white matter tract disruption in MRI hyperintensities. Biol Psychiatry. 2001; 50(3): 179–183.
11.WW Ishak , K Brown , SS Aye , etal. Health-related quality of life in bipolar disorder. Bipolar Disord. 2012; 14(1): 6–18.
12.MR Schneider , MP DelBello , RK McNamara , SM Strakowski , CM Adler . Neuroprogression in bipolar disorder. Bipolar Disord. 2012; 14(4): 356–374.
13.JL Beyer KR Krishnan . Volumetric brain imaging findings in mood disorders. Bipolar Disord. 2002; 4(2): 89–104.
14.MK Singh , KD Chang , MC Chen , etal. Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder. Bipolar Disord. 2012; 14(6): 585–596.
15.HA Baloch , JP Hatch , RL Olvera , etal. Morphology of the subgenual prefrontal cortex in pediatric bipolar disorder. J Psychiatr Res. 2010; 44(15): 1106–1110.
16.SK Tighe , SA Reading , P Rivkin , etal. Total white matter hyperintensity volume in bipolar disorder patients and their healthy relatives. Bipolar Disord. 2012; 14(8): 888–893.
17.G Serafini , M Pompili , M Innamorati , etal. White matter hyperintensities and self-reported depression in a sample of patients with chronic headache. J Headache Pain. 2012; 13(8): 661–667.
18.ML Oudega , E van Exel , MP Wattjes , etal. White matter hyperintensities, medial temporal lobe atrophy, cortical atrophy, and response to electroconvulsive therapy in severely depressed elderly patients. J Clin Psychiatry. 2011; 72(1): 104–112.
, etal. Affective temperamental profiles are associated with white matter hyperintensity and suicidal risk in patients with mood disorders. J Affect Disord. 2011; 129(1–3): 47–55.
20.G Serafini , M Pompili , M Innamorati , etal. Deep white matter hyperintensities as possible predictor of poor prognosis in a sample of patients with late-onset bipolar II disorder. Bipolar Disord. 2010; 12(7): 755–766.
21.FM Gunning-Dixon , M Walton , J Cheng , etal. MRI signal hyperintensities and treatment remission of geriatric depression. J Affect Disord. 2010; 126(3): 395–401.
22.S Köhler , AJ Thomas , A Lloyd , etal. White matter hyperintensities, cortisol levels, brain atrophy and continuing cognitive deficits in late-life depression. Br J Psychiatry. 2010; 196(2): 143–149.
23.S Bae , JE Kim , J Hwang , etal. Increased prevalence of white matter hyperintensities in patients with panic disorder. J Psychopharmacol. 2010; 24(5): 717–723.
24.G Fein , R Shimotsu , V Di Sclafani , J Barakos , C Harper . Increased white matter signal hyperintensities in long-term abstinent alcoholics compared with nonalcoholic controls. Alcohol Clin Exp Res. 2009; 33(1): 70–78.
25.M Pompili , M Innamorati , JJ Mann , etal. Periventricular white matter hyperintensities as predictors of suicide attempts in bipolar disorders and unipolar depression. Prog Neuropsychopharmacol Biol Psychiatry. 2008; 32(6): 1501–1507.
26.YI Sheline , JL Price , SN Vaishnavi , etal. Regional white matter hyperintensity burden in automated segmentation distinguishes late-life depressed subjects from comparison subjects matched for vascular risk factors. Am J Psychiatry. 2008; 165(4): 524–532.
27.WT Regenold , KC Hisley , P Phatak , etal. Relationship of cerebrospinal fluid glucose metabolites to MRI deep white matter hyperintensities and treatment resistance in bipolar disorder patients. Bipolar Disord. 2008; 10(7): 753–764.
28.K Takahashi , A Oshima , I Ida , etal. Relationship between age at onset and magnetic resonance image-defined hyperintensities in mood disorders. J Psychiatr Res. 2008; 42(6): 443–450.
29.MV Zanetti , MS Schaufelberger , CC de Castro , etal. White-matter hyperintensities in first-episode psychosis. Br J Psychiatry. 2008; 193(1): 25–30.
30.DV Iosifescu , PF Renshaw , DD Dougherty , etal. Major depressive disorder with anger attacks and subcortical MRI white matter hyperintensities. J Nerv Ment Dis. 2007; 195(2): 175–178.
31.TF Patankar , R Baldwin , D Mitra , etal. Virchow-Robin space dilatation may predict resistance to antidepressant monotherapy in elderly patients with depression. J Affect Disord. 2007; 97(1–3): 265–270.
32.SC Bae , IK Lyoo , YH Sung , etal. Increased white matter hyperintensitiesin male methamphetamine abusers. Drug Alcohol Depend. 2006; 81(1): 83–88.
33.DV Iosifescu , PF Renshaw , IK Lyoo , etal. Brain white-matter hyperintensities and treatment outcome in major depressive disorder. Br J Psychiatry. 2006; 188: 180–185.
34.KJ Anstey , AF Jorm , C Réglade-Meslin , etal. Weekly alcohol consumption, brain atrophy, and white matter hyperintensities in a community-based sample aged 60 to 64 years. Psychosom Med. 2006; 68(5): 778–785.
35.AF Jorm , KJ Anstey , H Christensen , etal. MRI hyperintensities and depressive symptoms in a community sample of individuals 60-64 years old. Am J Psychiatry. 2005; 162(4): 699–705.
36.HF Lin , YT Kuo , IC Chiang , HM Chen , CS Chen . Structural abnormality on brain magnetic resonance imaging in late-onset major depressive disorder. Kaohsiung J Med Sci. 2005; 21(9): 405–411.
37.I Hickie , S Naismith , PB Ward , etal. Vascular risk and low serum B12 predict white matter lesions in patients with major depression. J Affect Disord. 2005; 85(3): 327–332.
38.A Heiden , J Kettenbach , P Fischer , etal. White matter hyperintensities and chronicity of depression. J Psychiatr Res. 2005; 39(3): 285–293.
39.IK Lyoo , CC Streeter , KH Ahn , etal. White matter hyperintensities in subjects with cocaine and opiate dependence and healthy comparison subjects. Psychiatry Res. 2004; 131(2): 135–145.
40.MJ Firbank , AJ Lloyd , N Ferrier , JT O'Brien . A volumetric study of MRI signal hyperintensitiesin late-life depression. Am J Geriatr Psychiatry. 2004; 12(6): 606–612.
41.WD Taylor , DC Steffens , JR MacFall , etal. White matter hyperintensity progression and late-life depression outcomes. Arch Gen Psychiatry. 2003; 60(11): 1090–1096.
42.JL Breeze , DC Hesdorffer , X Hong , JA Frazier , PF Renshaw . Clinical significance of brain white matter hyperintensities in young adults with psychiatric illness. Harv Rev Psychiatry. 2003; 11(5): 269–283.
82.WD Taylor , JR Macfall , DC Steffens , etal. Localization of age-associated white matter hyperintensities in late-life depression. Prog Neuropsychopharmacol Biol Psychiatry. 2003; 27(3): 539–544.
45.T Silverstone , H McPherson , Q Li , T Doyle . Deep white matter hyperintensities in patients with bipolar depression, unipolar depression and age-matched control subjects. Bipolar Disord. 2003; 5(1): 53–57.
46.JJ Pillai , L Friedman , TA Stuve , etal. Increased presence of white matter hyperintensities in adolescent patients with bipolar disorder. Psychiatry Res. 2002; 114(1): 51–56.
47.EP Ahearn , KR Jamison , DC Steffens , etal. MRI correlates of suicide attempt history in unipolar depression. Biol Psychiatry. 2001; 50(4): 266–270.
48.P Rivkin , M Kraut , P Barta , etal. White matter hyperintensity volume in late-onset and early-onset schizophrenia. Int J Geriatr Psychiatry. 2000; 15(12): 1085–1089.
49.P Sachdev , H Brodaty , N Rose , S Cathcart . Schizophrenia with onset after age 50 years. 2: Neurological, neuropsychological and MRI investigation. Br J Psychiatry. 1999; 175: 416–421.
52.A Vasudev , A Thomas . ‘Bipolar disorder’ in the elderly: what's in a name? Maturitas. 2010; 66(3): 231–235.
54.E Vieta , T Suppes . Bipolar II disorder: arguments for and against a distinct diagnostic entity. Bipolar Disord. 2008; 10(1 Pt 2): 163–178.
55.PB Moore , DJ Shepherd , D Eccleston , etal. Cerebral white matter lesions in bipolar affective disorder: relationship to outcome. Br J Psychiatry. 2001; 178: 172–176.
56.F Cassidy . Insight in bipolar disorder: relationship to episode subtypes and symptom dimensions. Neuropsychiatr Dis Treat. 2010; 6(1): 627–631.
57.MJ Van Der Werf-Eldering , L Van Der Meer , H Burger , etal. Insight in bipolar disorder: associations with cognitive and emotional processing and illness characteristics. Bipolar Disord. 2011; 13(4): 343–354.
58.D Antonius , V Prudent , Y Rebani , etal. White matter integrity and lack of insight in schizophrenia and schizoaffective disorder. Schizophr Res. 2011; 128(1–3): 76–82.
59.DP Bassitt , MR Neto , CC De Castro , GF Busatto . Insight and regional brain volumes in schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2007; 257(1): 58–62.
60.L Palaniyappan , P Mallikarjun , V Joseph , PF Liddle . Appreciating symptoms and deficits in schizophrenia: right posterior insula and poor insight. Prog Neuropsychopharmacol Biol Psychiatry. 2011; 35(2): 523–527.
61.SL Rossell , J Coakes , J Shapleske , PW Woodruff , AS David . Insight: its relationship with cognitive function, brain volume and symptoms in schizophrenia. Psychol Med. 2003; 33(1): 111–119.
19.G Serafini , M Pompili , M Innamorati , etal. Affective temperamental profiles are associated with white matter hyperintensity and suicidal risk in patients with mood disorders. J Affect Disord. 2011; 129(1–3): 47–55.
65.M Pompili , Z Rihmer , HS Akiskal , etal. Temperament and personality dimensions in suicidal and nonsuicidal psychiatric inpatients. Psychopathology. 2008; 41(5): 313–321.
67.RC Young , JT Biggs , VE Ziegler , DA Meyer . A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry. 1978; 133(5): 429–435.
68.M Hamilton . A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960; 23(1): 56–62.
69.DV Sheehan , Y Lecrubier , KH Sheehan , etal. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSMIV and ICD-10. J Clin Psychiatry. 1998; 59(Suppl 20): 22–33; quiz 34–57.
70.AT Beck , A Weissman , D Lester , L Trexler . The measurement of pessimism: the hopelessness scale. J Consult Clin Psychol. 1974; 42(6): 861–865.
71.AT Beck , RA Steer . Clinical predictors of eventual suicide: a 5- to 10- year prospective study of suicide attempters. J Affect Disord. 1989; 17(3): 203–209.
72.CE Coffey , WE Wilkinson , RD Weiner , etal. Quantitative cerebral anatomy in depression: a controlled magnetic resonance imaging study. Arch Gen Psychiatry. 1993; 50(1): 7–16.
73.P Amorim , Y Lecrubier , E Weiller , T Hergueta , D Sheehan . DSM-IH-R psychotic disorders: procedural validity of the Mini International Neuropsychiatric Interview (MINI). Concordance and causes for discordance with the CIDI. Eur Psychiatry. 1998; 13(1): 26–34.
76.AD Craig . Interoception: the sense of the physiological condition of the body. Curr Opin Neurobiol. 2003; 13(4): 500–505.
77.GS Figiel , KR Krishnan , PM Doraiswamy , CB Nemeroff . Caudate hyperintensities in elderly depressed patients with neuroleptic-induced parkinsonism. J Geriatr Psychiatry Neurol. 1991; 4(2): 86–89.
78.BS Greenwald , E Kramer-Ginsberg , KR Krishnan , etal. Neuroanatomic localization of magnetic resonance imaging signal hyperintensities in geriatric depression. Stroke. 1998; 29(3): 613–617.
79.J Hwang , lk Lyoo , SR Dager , etal. Basal ganglia shape alterations in bipolar disorder. Am J Psychiatry. 2006; 163(2): 276–285.
80.DC Steffens , MJ Helms , KR Krishnan , GL Burke . Cerebrovascular disease and depression symptoms in the cardiovascular health study. Stroke. 1999; 30(10): 2159–2166.
81.SM Strakowski , MP Delbello , C Adler , DM Cecil , KW Sax . Neuroimaging in bipolar disorder. Bipolar Disord. 2000; 2(3 Pt 1): 148–164.
, etal. Localization of age-associated white matter hyperintensities in late-life depression. Prog Neuropsychopharmacol Biol Psychiatry. 2003; 27(3): 539–544.
83.C DeCarli , DG Murphy , M Tranh , etal. The effect of white matter hyperintensity volume on brain structure, cognitive performance, and cerebral metabolism of glucose in 51 healthy adults. Neurology. 1995; 45(11): 2077–2084.
85.Y Celik , E Erdogan , C Tuglu , U Utku . Post-stroke mania in late life due to right temporoparietal infarction. Psychiatry Clin Neurosci. 2004; 58(4): 446–447.
86.AM Kilbourne . The burden of general medical conditions in patients with bipolar disorder. Curr Psychiatry Rep. 2005; 7(6): 471–477.
87.WR Yates , R Wallace . Cardiovascular risk factors in affective disorder. J Affect Disord. 1987; 12(2): 129–134.
88.J Liu , BN Blond , LI van Dyck , etal. Trait and state corticostriatal dysfunction in bipolar disorder during emotional face processing. Bipolar Disord. 2012; 14(4): 432–441.
89.A Van der Schot , R Kahn , N Ramsey , W Nolen , M Vink . Trait and state dependent functional impairments in bipolar disorder. Psychiatry Res. 2010; 184(3): 135–142.
90.MU Shad , S Muddasani , K Prasad , JA Sweeney , MS Keshavan . Insight and prefrontal cortex in first-episode schizophrenia. Neuroimage. 2004; 22(3): 1315–1320.
91.TH Ha , T Youn , KS Ha , etal. Gray matter abnormalities in paranoid schizophrenia and their clinical correlations. Psychiatry Res. 2004; 132(3): 251–260.
92.AS David , A Buchanan , A Reed , O Almeida . The assessment of insight in psychosis. Br J Psychiatry. 1992; 161: 599–602.
93.M Birchwood , J Smith , V Drury , etal. A self-report insight scale for psychosis: reliability, validity and sensitivity to change. Acta Psychiatr Scand. 1994; 89(1): 62–67.
94.MJ Cuesta , V Peralta , A Zarzuela . Reappraising insight in psychosis: multi-scale longitudinal study. Br J Psychiatry. 2000; 177(3): 233–240.
95.RJ Drake , SW Lewis . Insight and neurocognition in schizophrenia. Schizophr Res. 2003; 62(1–2): 165–173.
96.TM Lincoln , E Lüllmann , W Rief . Correlates and long-term consequences of poor insight in patients with schizophrenia: a systematic review. Schizophr Bull. 2007; 33(6): 1324–1342.
97.M Sanz , G Constable , I Lopez-Ibor , R Kemp , AS David . A comparative study of insight scales and their relationship to psychopathological and clinical variables. Psychol Med. 1998; 28(2): 437–446.
98.RB Sassi , P Brambilla , M Nicoletti , etal. White matter hyperintensities in bipolar and unipolar patients with relatively mild-to-moderate illness severity. J Affect Disord. 2003; 77(3): 237–245.
99.R Persaud , H Russow , I Harvey , etal. Focal signal hyperintensities in schizophrenia. Schizophr Res. 1997; 27(1): 55–64.