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Development and Psychopathology Development and Psychopathology

Article contents

Understanding comorbidity among internalizing problems: Integrating latent structural models of psychopathology and risk mechanisms

Published online by Cambridge University Press:  14 October 2016

Benjamin L. Hankin ,
Hannah R. Snyder ,
Lauren D. Gulley ,
Tina H. Schweizer ,
Patricia Bijttebier ,
Sabine Nelis ,
Gim Toh  and
Michael W. Vasey
Benjamin L. Hankin*
Affiliation:
University of Illinois Urbana Champaign
Hannah R. Snyder
Affiliation:
Brandeis University
Lauren D. Gulley
Affiliation:
University of Washington
Tina H. Schweizer
Affiliation:
University of Illinois Urbana Champaign
Patricia Bijttebier
Affiliation:
Katholike University Leuven
Sabine Nelis
Affiliation:
Katholike University Leuven
Gim Toh
Affiliation:
Ohio State University
Michael W. Vasey
Affiliation:
Ohio State University
*
Address correspondence and reprint requests to: Benjamin L. Hankin, Department of Psychology, University of Illinois Urbana Champaign, 603 East Daniel Street, Champaign, IL 61820; E-mail: hankinb@illinois.edu.
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Abstract

It is well known that comorbidity is the rule, not the exception, for categorically defined psychiatric disorders, and this is also the case for internalizing disorders of depression and anxiety. This theoretical review paper addresses the ubiquity of comorbidity among internalizing disorders. Our central thesis is that progress in understanding this co-occurrence can be made by employing latent dimensional structural models that organize psychopathology as well as vulnerabilities and risk mechanisms and by connecting the multiple levels of risk and psychopathology outcomes together. Different vulnerabilities and risk mechanisms are hypothesized to predict different levels of the structural model of psychopathology. We review the present state of knowledge based on concurrent and developmental sequential comorbidity patterns among common discrete psychiatric disorders in youth, and then we advocate for the use of more recent bifactor dimensional models of psychopathology (e.g., p factor; Caspi et al., 2014) that can help to explain the co-occurrence among internalizing symptoms. In support of this relatively novel conceptual perspective, we review six exemplar vulnerabilities and risk mechanisms, including executive function, information processing biases, cognitive vulnerabilities, positive and negative affectivity aspects of temperament, and autonomic dysregulation, along with the developmental occurrence of stressors in different domains, to show how these vulnerabilities can predict the general latent psychopathology factor, a unique latent internalizing dimension, as well as specific symptom syndrome manifestations.

Type
Special Issue Articles
Information
Development and Psychopathology , Volume 28 , Special Issue 4pt1: Mechanisms of Comorbidity, Continuity, and Discontinuity in Psychopathology , November 2016 , pp. 987 - 1012
Copyright
Copyright © Cambridge University Press 2016 

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