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Assessing gene–environment interactions on anxiety symptom subtypes across childhood and adolescence

  • Jennifer Y. F. Lau (a1) (a2), Alice M. Gregory (a2) (a3), Michelle A. Goldwin (a1), Daniel S. Pine (a1) and Thalia C. Eley (a2)
  • DOI: http://dx.doi.org/10.1017/S0954579407000582
  • Published online: 11 October 2007
Abstract
Abstract

Consistent evidence shows both genetic and stress-related risks on child and adolescent anxiety, yet few studies have considered the degree to which genetic effects are moderated by stress (gene–environment interaction). We used longitudinal data from both a child and adolescent sample of twins to examine three novel issues on the presence of gene–environment interaction on anxiety symptoms. First, we assessed moderation of genetic risks on anxiety symptoms by negative life events in each age group. Second, by distinguishing between “stable” and “age-specific” genetic factors, we explored the continuity of gene–environment interaction across time and/or its emergence at specific ages. Third, we compared the presence of gene–environment interaction across different symptom types (general, panic, social, and separation). Genetic effects on separation anxiety symptoms in childhood (mean age = 8 years, 6 months) and panic anxiety symptoms in adolescence (mean age = 15 years) increased across independent negative life events. Shared environmental effects on separation anxiety symptoms and nonshared environmental effects on general anxiety symptoms in adolescence were also moderated by negative life events. We interpret these preliminary findings tentatively in the context of gene–environment interaction on anxiety in general, and on early separation and later panic anxiety in particular.

Copyright
Corresponding author
Address correspondence and reprint requests to: Jennifer Lau, NIMH/NIH, 15K, North Drive, Bethesda, MD 20892-2670; E-mail: lauj@mail.nih.gov.
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

J. Biederman , S. V. Farone , D. R. Hirshfeld-Becker , D. Friedman , J. A. Robin , & J. A. Rosenbaum (2001). Patterns of psychopathology and dysfunction in high-risk children of parents with panic disorder and major depression. American Journal of Psychiatry, 158, 4957.

B. Birmaher , D. A. Brent , L. Chiappetta , J. Bridge , S. Monga , & M. Baugher (1999). Psychometric properties of the Screen for Child Anxiety Related Emotional Disorders (SCARED): A replication study. Journal of the American Academy of Child & Adolescent Psychiatry, 38, 12301236.

E. J. Costello , S. Mustillo , A. Erkanli , G. Keeler , & A. Angold (2003). Prevalence and development of psychiatric disorders in childhood and adolescence. Archives of General Psychiatry, 60, 837844.

L. Eaves , J. Silberg , & A. Erkanli (2003). Resolving multiple epigenetic pathways to adolescent depression. Journal of Child Psychology and Psychiatry, 44, 10061014.

T. C. Eley , & J. Stevenson (1999). Exploring the covariation between anxiety and depression symptoms: A genetic analysis of the effects of age and sex. Journal of Child Psychology and Psychiatry, 40, 12731282.

T. C. Eley , K. Sugden , A. Corsico , A. M. Gregory , P. Sham , P. McGuffin , (2004). Gene–environment interaction analysis of serotonin system markers with adolescent depression. Molecular Psychiatry, 9, 908915.

S. A. Feigon , I. D. Waldman , F. Levy , & D. A. Hay (2001). Genetic and environmental influences on separation anxiety disorder symptoms and their moderation by age and sex. Behavior Genetics, 31, 403411.

N. A. Fox , K. E. Nichols , H. A. Henderson , K. Rubin , L. Schmidt , D. Hamer , (2005). Evidence for a gene–environment interaction in predicting behavioral inhibition in middle childhood. Psychological Science 16, 921926.

H. H. Goldsmith (1991). A zygosity questionnaire for young twins: A research note. Behavior Genetics, 21, 257269.

K. E. Grant , B. E. Compas , A. E. Thurm , S. D. McMahon , P. Y. Gipson , A. J. Campbell , (2006). Stressors and child and adolescent psychopathology: Evidence of moderating and mediating effects. Clinical Psychology Reviews, 26, 257283.

A. M. Gregory , T. C. Eley , & F. V. Rijsdijk (2006). A twin-study of sleep difficulties in school-aged children. Child Development, 77, 16681679.

C. Gross , & R. Hen (2004). The developmental origins of anxiety. Nature Reviews Neuroscience, 5, 545552.

A. R. Hariri , V. S. Mattay , A. Tessitore , B. Kolachana , F. Fera , D. Goldman , (2002). Serotonin transporter genetic variation and the response of the human amygdala. Science, 297, 400403.

J. M. Hettema , C. A. Prescott , J. M. Myers , M. C. Neale , & K. S. Kendler (2005). The structure of genetic and environmental risk factors for anxiety disorders in men and women. Archives of General Psychiatry, 62, 182189.

D. F. Klein (1964). Delineation of two drug-responsive anxiety syndromes. Psychopharmacologia, 5, 397408.

R. G. Klein (1995). Is panic disorder associated with childhood separation anxiety disorder? Clinical Neuropharmacology, 18 (Suppl. 2), S7S14.

A. K. Langley , R. L. Bergman , J. McCracken , & J. C. Piacentini (2004). Impairment in childhood anxiety disorders: Preliminary examination of the Child Anxiety Impact Scale—Parent version. Journal of Child and Adolescent Psychopharmacology, 14, 105114.

J. Y. Lau , & T. C. Eley (2006). Changes in genetic and environmental influences on depressive symptoms across adolescence and young adulthood. British Journal of Psychiatry, 189, 422427.

J. Y. Lau , & E. Viding (2007). Anxiety related biases in children's acquisition of stimulus–reinforcement associations. Behaviour Research and Therapy, 45, 16391646.

K. P. Lesch , D. Bengel , A. Heils , S. Z. Sabol , B. D. Greenberg , S. Petri , (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 15271531.

E. B. McClure , C. S. Monk , E. E. Nelson , J. M. Parrish , A. Adler , R. J. R. Blaire , (2007). Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder. Archives of General Psychiatry, 64, 97106.

H. Meltzer , R. Gatward , R. Goodman , & T. Ford (2000). Mental health of children and adolescents in Great Britain. International Review of Psychiatry, 15, 185187.

S. Monga , B. Birmaher , L. Chiappetta , D. Brent , J. Kaufman , J. Bridge , (2000). Screen for Child Anxiety-Related Emotional Disorders (SCARED): Convergent and divergent validity. Depression and Anxiety, 12, 8591.

D. S. Pine , R. G. Klein , J. D. Coplan , A. P. Laszlo , C. W. Hoven , J. Martinez , (2000). Differential carbon dioxide sensitivity in childhood anxiety disorders and nonill comparison group. Archives of General Psychiatry, 57, 960967.

D. S. Pine , R. G. Klein , S. Mannuzza , J. L. III Moulton , S. Lissek , M. Guardino , (2005). Face–emotion processing in offspring. Journal of the American Academy of Child & Adolescent Psychiatry, 44, 664672.

J. Silberg , M. Rutter , M. Neale , & L. Eaves (2001). Genetic moderation of environmental risk for depression and anxiety in adolescent girls. British Journal of Psychiatry, 179, 116121.

S. H. Spence (1997). Structure of anxiety symptoms among children: A confirmatory factor-analytic study. Journal of Abnormal Psychology, 106, 280297.

S. H. Spence (1998). A measure of anxiety symptoms among children. Behaviour Research and Therapy, 36, 545566.

T. D. Topolski , J. K. Hewitt , L. J. Eaves , J. L. Silberg , J. M. Meyer , M. Rutter , (1997). Genetic and environmental influences on child reports of manifest anxiety and symptoms of separation anxiety and overanxious disorders: A community-based twin study. Behavior Genetics, 27, 1528.

A. Trouton , F. M. Spinath , & R. Plomin (2002). Twins early development study (TEDS): A multivariate, longitudinal genetic investigation of language, cognition and behavior problems in childhood. Twin Research, 5, 444448.

M. W. Vasey , T. Dalgleish , & W. K. Silverman (2003). Research on information- processing factors in child and adolescent psychopathology: A critical commentary. Journal of Clinical Child & Adolescent Psychology, 32, 8193.

J. C. van der Valk , E. J. van den Oord , F. C. Verhulst , & D. I. Boomsma (2003). Genetic and environmental contributions to stability and change in children's internalizing and externalizing problems. Journal of the American Academy of Child & Adolescent Psychiatry, 42, 12121220.

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