Skip to main content
×
Home
    • Aa
    • Aa

A developmental increase in allostatic load from ages 3 to 11 years is associated with increased schizotypal personality at age 23 years

  • Melissa Peskin (a1), Adrian Raine (a1), Yu Gao (a1), Peter H. Venables (a2) and Sarnoff A. Mednick (a3)...
Abstract
Abstract

Although allostatic load has been investigated in mood and anxiety disorders, no prior study has investigated developmental change in allostatic load as a precursor to schizotypal personality. This study employed a multilevel developmental framework to examine whether the development of increased allostatic load, as indicated by impaired sympathetic nervous system habituation from ages 3 to 11 years, predisposes to schizotypal personality at age 23 years. Electrodermal activity to six aversive tones was recorded in 995 subjects at age 3 years and again at 11 years. Habituation slopes at both ages were used to create groups who showed a developmental increase in habituation (decreased allostatic load), and those who showed a developmental decrease in habituation (increased allostatic load). Children who showed a developmental increase in allostatic load from ages 3 to 11 years had higher levels of schizotypal personality at 23 years. A breakdown of total schizotypy scores demonstrated specificity of findings to cognitive–perceptual features of schizotypy. Findings are the first to document a developmental abnormality in allostasis in relation to adult schizotypal personality. The relative failure to develop normal habituation to repeated stressors throughout childhood is hypothesized to result in an accumulation of allostatic load and consequently increased positive symptom schizotypy in adulthood.

Copyright
Corresponding author
Address correspondence and reprint requests to: Melissa Peskin, Department of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104-6241; E-mail: peskinf@sas.upenn.edu.
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

M. Flaum , & N. C. Andreasen (1995). Brain morphology in schizotypal personality as assessed by magnetic resonance imaging. In A. Raine , T. Lencz , & S. A. Mednick (Eds.), Schizotypal personality disorder (pp. 385405). Cambridge: Cambridge University Press.

A. Raine , D. Benishay , T. Lencz , & A. Scarpa (1997). Abnormal orienting in schizotypal personality disorder. Schizophrenia Bulletin, 23, 7582.

T. E. Seeman , & B. S. McEwen (1996). Social environment characteristics and neuroendocrine function: The impact of social ties and support on neuroendocrine regulation. Psychosomatic Medicine, 58, 459471.

D. A. Silbersweig , E. Stern , C. D. Frith , C. Cahill , A. Hommes , S. Grootoonk , (1995). A functional neuroanatomy of hallucinations in schizophrenia. Nature, 378, 176179.

P. H. Venables (1978). Psychophysiology and psychometrics. Psychophysiology, 15, 302315.

A. R. Yung , & P.D. McGorry (1996). The prodromal phase of first-episode psychosis: Past and current conceptualizations. Schizophrenia Bulletin, 22, 353370.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Development and Psychopathology
  • ISSN: 0954-5794
  • EISSN: 1469-2198
  • URL: /core/journals/development-and-psychopathology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 1
Total number of PDF views: 13 *
Loading metrics...

Abstract views

Total abstract views: 129 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 26th March 2017. This data will be updated every 24 hours.