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Emotion regulation in children and adolescents: Boundaries between normalcy and bipolar disorder


Much controversy has surrounded the diagnosis of bipolar disorder (BD) in children and adolescents. However, recent work from an affective neuroscience perspective has advanced what is known about the boundaries of emotion regulation in BD compared to typically developing youth. In this article, we first briefly review the clinical issues that have contributed to this diagnostic controversy. Second, we discuss our phenotyping system, which can be used to guide neurobiological research designed to address these controversial issues. Third, we review what is known about the fundamentals of emotion regulation in human and nonhuman primate models. Fourth, we present recent data demonstrating how children and adolescents with BD differ from those without psychopathology on measures of emotion regulation. Taken as a whole, this work implicates a neural circuit encompassing the prefrontal cortex, amygdala, and striatum in the pathophysiology of pediatric BD.Both authors are affiliated with the Mood and Anxiety Disorders Program of the National Institute of Mental Health's Division of Intramural Research Programs (NIMH DIRP), which funded the work in its entirety. Dr. Dickstein is currently supported by a career development award (K22-MH 74945).

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Address correspondence and reprint requests to: Daniel P. Dickstein, National Institute of Mental Health, Pediatrics & Developmental Neuropsychiatry Branch, 9000 Rockville Pike, MSC 2670, Building 15K, Room 204, Bethesda, MD 20892-2670; E-mail:
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Adolphs, R., Baron-Cohen, S., & Tranel, D. (2002). Impaired recognition of social emotions following amygdala damage. Journal of Cognitive Neuroscience, 14, 12641274.

Adolphs, R., & Tranel, D. (2004). Impaired judgments of sadness but not happiness following bilateral amygdala damage. Journal of Cognitive Neuroscience, 16, 453462.

Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of Neuroscience, 9, 357381.

Altshuler, L. L., Bartzokis, G., Grieder, T., Curran, J., Jimenez, T., Leight, K.,et al. (2000). An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia. Biological Psychiatry, 48, 147162.

Barrett, J., Pike, G. B., & Paus, T. (2004). The role of the anterior cingulate cortex in pitch variation during sad affect. European Journal of Neuroscience, 19, 458464.

Bartels, A., & Zeki, S. (2004). The neural correlates of maternal and romantic love. Neuroimage, 21, 11551166.

Baxter, M. G., & Murray, E. A. (2002). The amygdala and reward. Nature Reviews. Neuroscience, 3, 563573.

Bhangoo, R. K., Dell, M. L., Towbin, K., Myers, F. S., Lowe, C. H., Pine, D. S.,et al. (2003). Clinical correlates of episodicity in juvenile mania. Journal of Child and Adolescent Psychopharmacology, 13, 507514.

Biederman, J., Faraone, S. V., Wozniak, J., Mick, E., Kwon, A., & Aleardi, M. (2004). Further evidence of unique developmental phenotypic correlates of pediatric bipolar disorder: findings from a large sample of clinically referred preadolescent children assessed over the last 7 years. Journal of Affective Disorders, 82(Suppl. 1), S45S58.

Biederman, J., Klein, R. G., Pine, D. S., & Klein, D. F. (1998). Resolved: Mania is mistaken for ADHD in prepubertal children. Journal of the American Academy of Child & Adolescent Psychiatry, 37, 10911096.

Birmaher, B., Axelson, D., Strober, M., Gill, M. K., Valeri, S., Chiappetta, L.,et al. (2006). Clinical course of children and adolescents with bipolar spectrum disorders. Archives of General Psychiatry, 63, 175183.

Birmaher, B., Kennah, A., Brent, D., Ehmann, M., Bridge, J., & Axelson, D. (2002). Is bipolar disorder specifically associated with panic disorder in youths?Journal of Clinical Psychiatry, 63, 414419.

Blair, R. J. (2004). The roles of orbital frontal cortex in the modulation of antisocial behavior. Brain Cognition, 55, 198208.

Blair, R. J., Morris, J. S., Frith, C. D., Perrett, D. I., & Dolan, R. J. (1999). Dissociable neural responses to facial expressions of sadness and anger. Brain, 122 (Pt. 5), 883893.

Blumberg, H. P., Fredericks, C. A., Wang, F., Kalmar, J. H., Spender, L., Papademetris, X.,et al. (2005). Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder. Bipolar Disorders, 7, 570576.

Blumberg, H. P., Kaufman, J., Martin, A., Charney, D. S., Krystal, J. H., & Peterson, B. S. (2004). Significance of adolescent neurodevelopment for the neural circuitry of bipolar disorder. Annals of the New York Academy of Sciences, 1021, 376383.

Blumberg, H. P., Kaufman, J., Martin, A., Whiteman, R., Zhang, J. H., Gore, J. C.,et al. (2003). Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder. Archives of General Psychiatry, 60, 12011208.

Blumberg, H. P., Leung, H. C., Skudlarski, P., Lacadie, C. M., Fredericks, C. A., Harris, B. C.,et al. (2003). A functional magnetic resonance imaging study of bipolar disorder: State- and trait-related dysfunction in ventral prefrontal cortices. Archives of General Psychiatry, 60, 601609.

Blumberg, H. P., Martin, A., Kaufman, J., Leung, H. C., Skudlarski, P., Lacadie, C.,et al. (2003). Frontostriatal abnormalities in adolescents with bipolar disorder: Preliminary observations from functional MRI. American Journal of Psychiatry, 160, 13451347.

Botvinick, M. M., Cohen, J. D., & Carter, C. S. (2004). Conflict monitoring and anterior cingulate cortex: An update. Trends in Cognitive Science, 8, 539546.

Brambilla, P., Harenski, K., Nicoletti, M., Sassi, R. B., Mallinger, A. G., Frank, E.,et al. (2003). MRI investigation of temporal lobe structures in bipolar patients. Journal of Psychiatric Ressearch, 37, 287295.

Braver, T. S., Barch, D. M., Gray, J. R., Molfese, D. L., & Snyder, A. (2001). Anterior cingulate cortex and response conflict: Effects of frequency, inhibition and errors. Cerebral Cortex, 11, 825836.

Breiter, H. C., Etcoff, N. L., Whalen, P. J., Kennedy, W. A., Rauch, S. L., Buckner, R. L.,et al. (1996). Response and habituation of the human amygdala during visual processing of facial expression. Neuron, 17, 875887.

Breiter, H. C., Gollub, R. L., Weisskoff, R. M., Kennedy, D. N., Makris, N., Berke, J. D.,et al. (1997). Acute effects of cocaine on human brain activity and emotion 2. Neuron, 19, 591611.

Bunge, S. A., Dudukovic, N. M., Thomason, M. E., Vaidya, C. J., & Gabrieli, J. D. (2002). Immature frontal lobe contributions to cognitive control in children: Evidence from fMRI. Neuron, 33, 301311.

Calarge, C., Andreasen, N. C., & O'Leary, D. S. (2003). Visualizing how one brain understands another: A PET study of theory of mind. American Journal of Psychiatry, 160, 19541964.

Carlson, G. A. (1998). Mania and ADHD: Comorbidity or confusion. Journal of Affective Disorders, 51, 177187.

Carlson, G. A., Jensen, P. S., Findling, R. L., Meyer, R. E., Calabrese, J., DelBello, M. P.,et al. (2003). Methodological issues and controversies in clinical trials with child and adolescent patients with bipolar disorder: Report of a consensus conference. Journal of Child and Adolescent Psychopharmacology, 13, 1327.

Carlson, G. A., & Strober, M. (1978). Manic-depressive illness in early adolescence. A study of clinical and diagnostic characteristics in six cases. Journal of the American Academy of Child Psychiatry, 17, 138153.

Carter, C. S., Macdonald, A. M., Botvinick, M., Ross, L. L., Stenger, V. A., Noll, D.,et al. (2000). Parsing executive processes: Strategic vs. evaluative functions of the anterior cingulate cortex. Proceedings of the National Academy of Sciences of the USA, 97, 19441948.

Casey, B. J., Durston, S., & Fossella, J. A. (2001). Evidence for a mechanistic model of cognitive control. Clinical Neuroscience Research, 1, 267282.

Casey, B. J., Tottenham, N., & Fossella, J. (2002). Clinical, imaging, lesion, and genetic approaches toward a model of cognitive control. Developmental Psychobiology, 40, 237254.

Chang, K., Adleman, N., Dienes, K., Barnea-Goraly, N., Reiss, A., & Ketter, T. (2003). Decreased N-acetylaspartate in children with familial bipolar disorder. Biological Psychiatry, 53, 10591065.

Chang, K., Adleman, N. E., Dienes, K., Simeonova, D. I., Menon, V., & Reiss, A. (2004). Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder: A functional magnetic resonance imaging investigation. Archives in General Psychiatry, 61, 781792.

Chang, K., Karchemskiy, A., Barnea-Goraly, N., Garrett, A., Simeonova, D. I., & Reiss, A. (2005). Reduced amygdalar gray matter volume in familial pediatric bipolar disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 44, 565573.

Chen, B. K., Sassi, R., Axelson, D., Hatch, J. P., Sanches, M., Nicoletti, M.,et al. (2004). Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorder. Biological Psychiatry, 56, 399405.

Chen, C. H., Lennox, B., Jacob, R., Calder, A., Lupson, V., Bisbrown-Chippendale, R.,et al. (2006). Explicit and implicit facial affect recognition in manic and depressed States of bipolar disorder: A functional magnetic resonance imaging study. Biological Psychiatry, 59, 3139.

Clark, L., Cools, R., & Robbins, T. W. (2004). The neuropsychology of ventral prefrontal cortex: Decision-making and reversal learning. Brain Cognition, 55, 4153.

Clark, L., Iversen, S. D., & Goodwin, G. M. (2001). A neuropsychological investigation of prefrontal cortex involvement in acute mania. American Journal of Psychiatry, 158, 16051611.

Clark, L., Iversen, S. D., & Goodwin, G. M. (2002). Sustained attention deficit in bipolar disorder. British Journal of Psychiatry, 180, 313319.

Cole, P. M., Martin, S. E., & Dennis, T. A. (2004). Emotion regulation as a scientific construct: Methodological challenges and directions for child development research. Child Development, 75, 317333.

Compton, R. J., Banich, M. T., Mohanty, A., Milham, M. P., Herrington, J., Miller, G. A.,et al. (2003). Paying attention to emotion: An fMRI investigation of cognitive and emotional stroop tasks. Cognitive, Affective Behavioral Neuroscience, 3, 8196.

Cools, R., Clark, L., & Robbins, T. W. (2004). Differential responses in human striatum and prefrontal cortex to changes in object and rule relevance. Journal of Neuroscience, 24, 11291135.

D'Esposito, M., & Postle, B. R. (1999). The dependence of span and delayed-response performance on prefrontal cortex. Neuropsychologia, 37, 13031315.

Dahl, R. E. (2004). Adolescent brain development: A period of vulnerabilities and opportunities. Keynote address. Annals of the New York Academy of Science, 1021, 122.

Damasio, H., Grabowski, T., Frank, R., Galaburda, A. M., & Damasio, A. R. (1994). The return of Phineas Gage: Clues about the brain from the skull of a famous patient. Science, 264, 11021105.

Davidson, R. J. (2004). What does the prefrontal cortex “do” in affect: Perspectives on frontal EEG asymmetry research. Biological Psychology, 67, 219234.

Davis, M., & Whalen, P. J. (2001). The amygdala: Vigilance and emotion. Molecular Psychiatry, 6, 1334.

DelBello, M. P., Zimmerman, M. E., Mills, N. P., Getz, G. E., & Strakowski, S. M. (2004). Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder. Bipolar Disorder, 6, 4352.

Delgado, M. R., Stenger, V. A., & Fiez, J. A. (2004). Motivation-dependent responses in the human caudate nucleus. Cerebral Cortex, 14, 10221030.

Derryberry, D., & Reed, M. A. (1994). Temperament and attention: Orienting toward and away from positive and negative signals. Journal of Personality and Social Psychology, 66, 11281139.

Dickstein, D. P., Garvey, M., Pradella, A. G., Greenstein, D. K., Sharp, W. S., Castellanos, F. X.,et al. (2005). Neurologic examination abnormalities in children with bipolar disorder or attention-deficit/hyperactivity disorder. Biological Psychiatry, 58, 517524.

Dickstein, D. P., Milham, M. P., Nugent, A. C., Drevets, W. C., Charney, D. S., Pine, D. S.,et al. (2005). Frontotemporal alterations in pediatric bipolar disorder: Results of a voxel-based morphometry study. Archives of General Psychiatry, 62, 734741.

Dickstein, D. P., Rich, B. A., Binstock, A. B., Pradella, A. G., Towbin, K. E., Pine, D. S.,et al. (2005). Comorbid anxiety in phenotypes of pediatric bipolar disorder. Journal of Child and Adolescent Psychopharmacology, 15, 534548.

Dickstein, D. P., Treland, J. E., Snow, J., McClure, E. B., Mehta, M. S., Towbin, K. E.,et al. (2004). Neuropsychological performance in pediatric bipolar disorder. Biological Psychiatry, 55, 3239.

Dilsaver, S. C., Chen, Y. W., Swann, A. C., Shoaib, A. M., Tsai-Dilsaver, Y., & Krajewski, K. J. (1997). Suicidality, panic disorder and psychosis in bipolar depression, depressive-mania and pure-mania. Psychiatry Research, 73, 4756.

Dittmann, S., Biedermann, N. C., Grunze, H., Hummel, B., Scharer, L. O., Kleindienst, N.,et al. (2002). The Stanley Foundation Bipolar Network: Results of the naturalistic follow-up study after 2.5 years of follow-up in the German centres. Neuropsychobiology, 46(Suppl. 1), 29.

Drevets, W. C., Ongur, D., & Price, J. L. (1998). Neuroimaging abnormalities in the subgenual prefrontal cortex: Implications for the pathophysiology of familial mood disorders. Molecular Psychiatry, 3, 220221.

Durston, S., Thomas, K. M., Worden, M. S., Yang, Y., & Casey, B. J. (2002). The effect of preceding context on inhibition: An event-related fMRI study. Neuroimage, 16, 449453.

Ernst, M., Dickstein, D. P., Munson, S., Eshel, N., Pradella, A. G., Jazbec, S.,et al. (2004). Reward-related processes in pediatric bipolar disorder: A pilot study. Journal of Affective Disorders, 82, S89S101.

Ernst, M., Nelson, E. E., Jazbec, S., McClure, E. B., Monk, C. S., Leibenluft, E.,et al. (2005). Amygdala and nucleus accumbens in responses to receipt and omission of gains in adults and adolescents. Neuroimage, 25, 12791291.

Farroni, T., Csibra, G., Simion, F., & Johnson, M. H. (2002). Eye contact detection in humans from birth. Proceedings of the National Academy of Science of the USA, 99, 96029605.

Feske, U., Frank, E., Mallinger, A. G., Houck, P. R., Fagiolini, A., Shear, M. K.,et al. (2000). Anxiety as a correlate of response to the acute treatment of bipolar I disorder. American Journal of Psychiatry, 157, 956962.

Fletcher, P. C., Happe, F., Frith, U., Baker, S. C., Dolan, R. J., Frackowiak, R. S.,et al. (1995). Other minds in the brain: A functional imaging study of “theory of mind” in story comprehension. Cognition, 57, 109128.

Fonagy, P., Steele, M., Moran, G., Steele, H., & Higgitt, A. (1993). Measuring the ghost in the nursery: An empirical study of the relation between parents' mental representations of childhood experiences and their infants' security of attachment. Journal of the American Psychoanalytic Association, 41, 957989.

Forbes, E. E., & Dahl, R. E. (2005). Neural systems of positive affect: Relevance to understanding child and adolescent depression?Development and Psychopathology, 17, 827850.

Frank, E., Cyranowski, J. M., Rucci, P., Shear, M. K., Fagiolini, A., Thase, M. E.,et al. (2002). Clinical significance of lifetime panic spectrum symptoms in the treatment of patients with bipolar I disorder. Archives of General Psychiatry, 59, 905911.

Frazier, J. A., Chiu, S., Breeze, J. L., Makris, N., Lange, N., Kennedy, D. N.,et al. (2005). Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder. American Journal of Psychiatry, 162, 12561265.

Freeman, M. P., Freeman, S. A., & McElroy, S. L. (2002). The comorbidity of bipolar and anxiety disorders: Prevalence, psychobiology, and treatment issues. Journal of Affective Disorders, 68, 123.

Fuster, J. M. (2000). Prefrontal neurons in networks of executive memory. Brain Research Bulletin, 52, 331336.

Gauthier, I., Tarr, M. J., Anderson, A. W., Skudlarski, P., & Gore, J. C. (1999). Activation of the middle fusiform “face area” increases with expertise in recognizing novel objects. Nature Neuroscience, 2, 568573.

Geller, B., Bolhofner, K., Craney, J. L., Williams, M., DelBello, M. P., & Gundersen, K. (2000). Psychosocial functioning in a prepubertal and early adolescent bipolar disorder phenotype. Journal of the American Academy of Child & Adolescent Psychiatry, 39, 15431548.

Geller, B., Tillman, R., Craney, J. L., & Bolhofner, K. (2004). Four-year prospective outcome and natural history of mania in children with a prepubertal and early adolescent bipolar disorder phenotype. Archives of General Psychiatry, 61, 459467.

Geller, B., Williams, M., Zimerman, B., Frazier, J., Beringer, L., & Warner, K. L. (1998). Prepubertal and early adolescent bipolarity differentiate from ADHD by manic symptoms, grandiose delusions, ultra-rapid or ultradian cycling. Journal of Affective Disorders, 51, 8191.

Geller, B., Zimerman, B., Williams, M., DelBello, M. P., Bolhofner, K., Craney, J. L.,et al. (2002). DSM-IV mania symptoms in a prepubertal and early adolescent bipolar disorder phenotype compared to attention-deficit hyperactive and normal controls. Journal of Child and Adolescent Psychopharmacology, 12, 1125.

Giedd, J. N. (2004). Structural magnetic resonance imaging of the adolescent brain. Annals of the New York Academy of Sciences, 1021, 7785.

Gobbini, M. I., Leibenluft, E., Santiago, N., & Haxby, J. V. (2004). Social and emotional attachment in the neural representation of faces. Neuroimage, 22, 16281635.

Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituzis, A. C.,et al. (2004). Dynamic mapping of human cortical development during childhood through early adulthood. Proceedings of the National Academy of Sciences of the USA, 101, 81748179.

Goldman-Rakic, P. S. (1987). Development of cortical circuitry and cognitive function. Child Development, 58, 601622.

Gorrindo, T., Blair, R. J., Budhani, S., Dickstein, D. P., Pine, D. S., & Leibenluft, E. (2005). Deficits on a probabilistic response-reversal task in patients with pediatric bipolar disorder. American Journal of Psychiatry, 162, 19751977.

Gottfried, J. A., O'Doherty, J., & Dolan, R. J. (2003). Encoding predictive reward value in human amygdala and orbitofrontal cortex. Science, 301, 11041107.

Hariri, A. R., Bookheimer, S. Y., & Mazziotta, J. C. (2000). Modulating emotional responses: Effects of a neocortical network on the limbic system. Neuroreport, 11, 4348.

Hariri, A. R., Drabant, E. M., Munoz, K. E., Kolachana, B. S., Mattay, V. S., Egan, M. F.,et al. (2005). A susceptibility gene for affective disorders and the response of the human amygdala. Archives of General Psychiatry, 62, 146152.

Harpold, T. L., Wozniak, J., Kwon, A., Gilbert, J., Wood, J., Smith, L.,et al. (2005). Examining the association between pediatric bipolar disorder and anxiety disorders in psychiatrically referred children and adolescents. Journal of Affective Disorders, 88, 1926.

Haruno, M., Kuroda, T., Doya, K., Toyama, K., Kimura, M., Samejima, K.,et al. (2004). A neural correlate of reward-based behavioral learning in caudate nucleus: A functional magnetic resonance imaging study of a stochastic decision task. Journal of Neuroscience, 24, 16601665.

Hauser, P., Matochik, J., Altshuler, L. L., Denicoff, K. D., Conrad, A., Li, X.,et al. (2000). MRI-based measurements of temporal lobe and ventricular structures in patients with bipolar I and bipolar II disorders. Journal of Affective Disorders, 60, 2532.

Haxby, J. V., Hoffman, E. A., & Gobbini, M. I. (2002). Human neural systems for face recognition and social communication. Biological Psychiatry, 51, 5967.

Henry, C., Van den, B. D., Bellivier, F., Etain, B., Rouillon, F., & Leboyer, M. (2003). Anxiety disorders in 318 bipolar patients: Prevalence and impact on illness severity and response to mood stabilizer. Journal of Clinical Psychiatry, 64, 331335.

Holland, P. C., & Gallagher, M. (2003). Double dissociation of the effects of lesions of basolateral and central amygdala on conditioned stimulus-potentiated feeding and Pavlovian-instrumental transfer. European Journal of Neuroscience, 17, 16801694.

Izquierdo, A., & Murray, E. A. (2004). Combined unilateral lesions of the amygdala and orbital prefrontal cortex impair affective processing in rhesus monkeys. Journal of Neurophysiology, 91, 20232039.

Johnson, M. H., Dziurawiec, S., Ellis, H., & Morton, J. (1991). Newborns' preferential tracking of face-like stimuli and its subsequent decline. Cognition, 40, 119.

Jonkman, L. M., Kemner, C., Verbaten, M. N., Van Engeland, H., Camfferman, G., Buitelaar, J. al. (2000). Attentional capacity, a probe ERP study: Differences between children with attention-deficit hyperactivity disorder and normal control children and effects of methylphenidate. Psychophysiology, 37, 334346.

Kaufman, J., Birmaher, B., Brent, D., Rao, U., Flynn, C., Moreci, P.,et al. (1997). Schedule for Affective Disorders and Schizophrenia for School-Age Children—Present and Lifetime Version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy of Child & Adolescent Psychiatry, 36, 980988.

Kaur, S., Sassi, R. B., Axelson, D., Nicoletti, M., Brambilla, P., Monkul, E. S.,et al. (2005). Cingulate cortex anatomical abnormalities in children and adolescents with bipolar disorder. American Journal of Psychiatry, 162, 16371643.

Kerr, N., Dunbar, R. I., & Bentall, R. P. (2003). Theory of mind deficits in bipolar affective disorder. Journal of Affective Disorders, 73, 253259.

Killgore, W. D., & Yurgelun-Todd, D. A. (2004). Activation of the amygdala and anterior cingulate during nonconscious processing of sad versus happy faces. Neuroimage, 21, 12151223.

Kluver, H., & Bucy, P. C. (1997). Preliminary analysis of functions of the temporal lobes in monkeys. 1939. Journal of Neuropsychiatry and Clinical Neurosciences, 9, 606620.

Knutson, B., Westdorp, A., Kaiser, E., & Hommer, D. (2000). FMRI visualization of brain activity during a monetary incentive delay task. Neuroimage, 12, 2027.

Koski, L., & Paus, T. (2000). Functional connectivity of the anterior cingulate cortex within the human frontal lobe: A brain-mapping meta-analysis. Experimental Brain Research, 133, 5565.

Koulomzin, M., Beebe, B., Anderson, S., Jaffe, J., Feldstein, S., & Crown, C. (2002). Infant gaze, head, face and self-touch at 4 months differentiate secure vs. avoidant attachment at 1 year: A microanalytic approach. Attachment and Human Development, 4, 324.

Lang, P. J., Bradley, M. M., & Cuthbert, B. N. (1998). Emotion, motivation, and anxiety: brain mechanisms and psychophysiology. Biological Psychiatry, 44, 12481263.

Leckman, J. F., Sholomskas, D., Thompson, W. D., Belanger, A., & Weissman, M. M. (1982). Best estimate of lifetime psychiatric diagnosis: A methodological study. Archives of General Psychiatry, 39, 879883.

LeDoux, J. (2003). The emotional brain, fear, and the amygdala. Cell and Molecular Neurobiology, 23, 727738.

Lehmann, C., Mueller, T., Federspiel, A., Hubl, D., Schroth, G., Huber, O.,et al. (2004). Dissociation between overt and unconscious face processing in fusiform face area. Neuroimage, 21, 7583.

Leibenluft, E., Blair, R. J., Charney, D. S., & Pine, D. S. (2003). Irritability in pediatric mania and other childhood psychopathology. Annals of the New York Academy of Sciences, 1008, 201218.

Leibenluft, E., Charney, D. S., Towbin, K. E., Bhangoo, R. K., & Pine, D. S. (2003). Defining clinical phenotypes of juvenile mania. American Journal of Psychiatry, 160, 430437.

Leibenluft, E., Gobbini, M. I., Harrison, T., & Haxby, J. V. (2004). Mothers' neural activation in response to pictures of their children and other children. Biological Psychiatry, 56, 225232.

Lembke, A., & Ketter, T. A. (2002). Impaired recognition of facial emotion in mania. American Journal of Psychiatry, 159, 302304.

Logan, G. D., Schachar, R. J., & Tannock, R. (1997). Impulsivity and inhibitory control. Psychological Science, 8, 6064.

Loiselle, D. L., Stamm, J. S., Maitinsky, S., & Whipple, S. C. (1980). Evoked potential and behavioral signs of attentive dysfunctions in hyperactive boys. Psychophysiology, 17, 193201.

Lyoo, I. K., Kim, M. J., Stoll, A. L., Demopulos, C. M., Parow, A. M., Dager, S. R.,et al. (2004). Frontal lobe gray matter density decreases in bipolar I disorder. Biological Psychiatry, 55, 648651.

MacLeod, C. M., & MacDonald, P. A. (2000). Interdimensional interference in the Stroop effect: Uncovering the cognitive and neural anatomy of attention. Trends in Cognitive Science, 4, 383391.

May, J. C., Delgado, M. R., Dahl, R. E., Stenger, V. A., Ryan, N. D., Fiez, J. A.,et al. (2004). Event-related functional magnetic resonance imaging of reward-related brain circuitry in children and adolescents. Biological Psychiatry, 55, 359366.

McClure, E. B., Pope, K., Hoberman, A. J., Pine, D. S., & Leibenluft, E. (2003). Facial expression recognition in adolescents with mood and anxiety disorders. American Journal of Psychiatry, 160, 11721174.

McClure, E. B., Treland, J. E., Snow, J., Schmajuk, M., Dickstein, D. P., Towbin, K. E.,et al. (2005). Deficits in social cognition and response flexibility in pediatric bipolar disorder. American Journal of Psychiatry, 162, 16441651.

McManis, M. H., Bradley, M. M., Berg, W. K., Cuthbert, B. N., & Lang, P. J. (2001). Emotional reactions in children: Verbal, physiological, and behavioral responses to affective pictures. Psychophysiology, 38, 222231.

Meunier, M., Bachevalier, J., & Mishkin, M. (1997). Effects of orbital frontal and anterior cingulate lesions on object and spatial memory in rhesus monkeys. Neuropsychologia, 35, 9991015.

Monk, C. S., McClure, E. B., Nelson, E. E., Zarahn, E., Bilder, R. M., Leibenluft, E.,et al. (2003). Adolescent immaturity in attention-related brain engagement to emotional facial expressions. Neuroimage, 20, 420428.

Moore, C. M., Biederman, J., Wozniak, J., Mick, E., Aleardi, M., Wardrop, M.,et al. (2006). Differences in brain chemistry in children and adolescents with attention deficit hyperactivity disorder with and without comorbid bipolar disorder: A proton magnetic resonance spectroscopy study. American Journal of Psychiatry, 163, 316318.

Nelson, E. E., Leibenluft, E., McClure, E. B., & Pine, D. S. (2005). The social re-orientation of adolescence: A neuroscience perspective on the process and its relation to psychopathology. Psychological Medicine, 35, 163174.

Nitschke, J. B., Nelson, E. E., Rusch, B. D., Fox, A. S., Oakes, T. R., & Davidson, R. J. (2004). Orbitofrontal cortex tracks positive mood in mothers viewing pictures of their newborn infants. Neuroimage, 21, 583592.

Nowicki, S., & Duke, M. (1994). Individual differences in the nonverbal communication of affect: The Diagnostic Analysis of Nonverbal Accuracy Scale. Journal of Nonverbal Behavior, 18, 935.

O'Doherty, J., Dayan, P., Schultz, J., Deichmann, R., Friston, K., & Dolan, R. J. (2004). Dissociable roles of ventral and dorsal striatum in instrumental conditioning. Science, 304, 452454.

Olvera, R. L., Semrud-Clikeman, M., Pliszka, S. R., & O'Donnell, L. (2005). Neuropsychological deficits in adolescents with conduct disorder and comorbid bipolar disorder: A pilot study. Bipolar Disorder, 7, 5767.

Pasupathy, A., & Miller, E. K. (2005). Different time courses of learning-related activity in the prefrontal cortex and striatum. Nature, 433, 873876.

Pearlson, G. D., Barta, P. E., Powers, R. E., Menon, R. R., Richards, S. S., Aylward, E. H.,et al. (1997). Ziskind-Somerfeld Research Award 1996. Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder. Biological Psychiatry, 41, 114.

Perchet, C., Revol, O., Fourneret, P., Mauguiere, F., & Garcia-Larrea, L. (2001). Attention shifts and anticipatory mechanisms in hyperactive children: An ERP study using the Posner paradigm. Biological Psychiatry, 50, 4457.

Pessoa, L., McKenna, M., Gutierrez, E., & Ungerleider, L. G. (2002). Neural processing of emotional faces requires attention. Proceedings of the National Academy of Sciences of the USA, 99, 1145811463.

Pessoa, L., & Ungerleider, L. G. (2004). Neuroimaging studies of attention and the processing of emotion-laden stimuli. Progress in Brain Research, 144, 171182.

Phillips, M. L., Williams, L. M., Heining, M., Herba, C. M., Russell, T., Andrew, C.,et al. (2004). Differential neural responses to overt and covert presentations of facial expressions of fear and disgust. Neuroimage, 21, 14841496.

Polich, J., & Herbst, K. L. (2000). P300 as a clinical assay: Rationale, evaluation, and findings. International Journal of Psychophysiology, 38, 319.

Posner, M. I., & Rothbart, M. K. (1998). Attention, self-regulation and consciousness. Philosophical Transactions of the Royal Society of London, Series B, Biological Sciences, 353, 19151927.

Puig-Antich, J., Blau, S., Marx, N., Greenhill, L. L., & Chambers, W. (1978). Prepubertal major depressive disorder: A pilot study. Journal of the American Academy of Child Psychiatry, 17, 695707.

Rich, B. A., Schmajuk, M., Perez-Edgar, K. E., Pine, D. S., Fox, N. A., & Leibenluft, E. (2005). The impact of reward, punishment, and frustration on attention in pediatric bipolar disorder. Biological Psychiatry, 58, 532539.

Rich, B. A., Vinton, D. T., Roberson-Nay, R., Hommer, R. E., Berghorst, L. H., McClure, E. B.,et al. (2006). Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder. Proceedings of the National Academy of Science of the USA, 103, 89008905.

Risinger, R. C., Salmeron, B. J., Ross, T. J., Amen, S. L., Sanfilipo, M., Hoffmann, R. G.,et al. (2005). Neural correlates of high and craving during cocaine self-administration using BOLD fMRI. Neuroimage, 26, 10971108.

Rogers, R. D., Ramnani, N., Mackay, C., Wilson, J. L., Jezzard, P., Carter, C. S.,et al. (2004). Distinct portions of anterior cingulate cortex and medial prefrontal cortex are activated by reward processing in separable phases of decision-making cognition. Biological Psychiatry, 55, 594602.

Rolls, E. T. (2000). The orbitofrontal cortex and reward. Cerebral Cortex, 10, 284294.

Rolls, E. T., O'Doherty, J., Kringelbach, M. L., Francis, S., Bowtell, R., & McGlone, F. (2003). Representations of pleasant and painful touch in the human orbitofrontal and cingulate cortices. Cerebral Cortex, 13, 308317.

Rubinsztein, J. S., Fletcher, P. C., Rogers, R. D., Ho, L. W., Aigbirhio, F. I., Paykel, E. S.,et al. (2001). Decision-making in mania: A PET study. Brain, 124, 25502563.

Rubinsztein, J. S., Michael, A., Paykel, E. S., & Sahakian, B. J. (2000). Cognitive impairment in remission in bipolar affective disorder. Psychological Medicine, 30, 10251036.

Sanches, M., Roberts, R. L., Sassi, R. B., Axelson, D., Nicoletti, M., Brambilla, P.,et al. (2005). Developmental abnormalities in striatum in young bipolar patients: A preliminary study. Bipolar Disorder, 7, 153158.

Sanches, M., Sassi, R. B., Axelson, D., Nicoletti, M., Brambilla, P., Hatch, J. P.,et al. (2005). Subgenual prefrontal cortex of child and adolescent bipolar patients: A morphometric magnetic resonance imaging study. Psychiatry Research, 138, 4349.

Sax, K. W., Strakowski, S. M., Zimmerman, M. E., DelBello, M. P., Keck, P. E., Jr., & Hawkins, J. M. (1999). Frontosubcortical neuroanatomy and the continuous performance test in mania. American Journal of Psychiatry, 156, 139141.

Schultz, W., Tremblay, L., & Hollerman, J. R. (1998). Reward prediction in primate basal ganglia and frontal cortex. Neuropharmacology, 37, 421429.

Shaffer, D., Fisher, P., Dulcan, M. K., Davies, M., Piacentini, J., Schwab-Stone, M. E.,et al. (1996). The NIMH Diagnostic Interview Schedule for Children Version 2.3 (DISC-2.3): description, acceptability, prevalence rates, and performance in the MECA Study. Methods for the Epidemiology of Child and Adolescent Mental Disorders Study. Journal of the American Academy of Child & Adolescent Psychiatry, 35, 865877.

Sowell, E. R., Thompson, P. M., Leonard, C. M., Welcome, S. E., Kan, E., & Toga, A. W. (2004). Longitudinal mapping of cortical thickness and brain growth in normal children. Journal of Neuroscience, 24, 82238231.

Steger, J., Imhof, K., Coutts, E., Gundelfinger, R., Steinhausen, H. C., & Brandeis, D. (2001). Attentional and neuromotor deficits in ADHD. Developmental Medicine and Child Neurology, 43, 172179.

Stone, V. E., Baron-Cohen, S., & Knight, R. T. (1998). Frontal lobe contributions to theory of mind. Journal of Cognitive Neuroscience, 10, 640656.

Strakowski, S. M., DelBello, M. P., Sax, K. W., Zimmerman, M. E., Shear, P. K., Hawkins, J. M.,et al. (1999). Brain magnetic resonance imaging of structural abnormalities in bipolar disorder. Archives of General Psychiatry, 56, 254260.

Striano, T. (2001). From social expectations to social cognition in early infancy. Bulletin of the Menninger Clinic, 65, 361370.

Stuss, D. T., & Levine, B. (2002). Adult clinical neuropsychology: Lessons from studies of the frontal lobes. Annual Review of Psychology, 53, 401433.

Sweeney, J. A., Kmiec, J. A., & Kupfer, D. J. (2000). Neuropsychologic impairments in bipolar and unipolar mood disorders on the CANTAB neurocognitive battery. Biological Psychiatry, 48, 674684.

Thompson, R. A. (1994). Emotion regulation: A theme in search of definition. Monographs of the Society for Research in Child Development, 59, 2552.

Thorpe, S. J., Rolls, E. T., & Maddison, S. (1983). The orbitofrontal cortex: neuronal activity in the behaving monkey. Experimental Brain Research, 49, 93115.

Trepagnier, C., Sebrechts, M. M., & Peterson, R. (2002). Atypical face gaze in autism. Cyberpsychology Behavior, 5, 213217.

Ungerleider, L. G., Courtney, S. M., & Haxby, J. V. (1998). A neural system for human visual working memory. Proceedings of the National Academy of Sciences of the USA, 95, 883890.

Volkow, N. D., Wang, G. J., Fowler, J. S., Logan, J., Jayne, M., Franceschi, D.,et al. (2002). “Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect. Synapse, 44, 175180.

Weissman, M. M., & Myers, J. K. (1978). Affective disorders in a US urban community: The use of research diagnostic criteria in an epidemiological survey. Archives in General Psychiatry, 35, 13041311.

Wilens, T. E., Biederman, J., Millstein, R. B., Wozniak, J., Hahesy, A. L., & Spencer, T. J. (1999). Risk for substance use disorders in youths with child- and adolescent-onset bipolar disorder. Jouranl of the American Academy of Child and Adolescent Psychiatry, 38, 680685.

Wilke, M., Kowatch, R. A., DelBello, M. P., Mills, N. P., & Holland, S. K. (2004). Voxel-based morphometry in adolescents with bipolar disorder: First results. Psychiatry Research, 131, 5769.

Williams, M. A., Morris, A. P., McGlone, F., Abbott, D. F., & Mattingley, J. B. (2004). Amygdala responses to fearful and happy facial expressions under conditions of binocular suppression. Journal of Neuroscience, 24, 28982904.

Wozniak, J., Biederman, J., Kiely, K., Ablon, J. S., Faraone, S. V., Mundy, E.,et al. (1995). Mania-like symptoms suggestive of childhood-onset bipolar disorder in clinically referred children. Journal of the American Academy of Child & Adolescent Psychiatry, 34, 867876.

Zald, D. H., Boileau, I., El Dearedy, W., Gunn, R., McGlone, F., Dichter, G. S.,et al. (2004). Dopamine transmission in the human striatum during monetary reward tasks. Journal of Neuroscience, 24, 41054112.

Zink, C. F., Pagnoni, G., Martin-Skurski, M. E., Chappelow, J. C., & Berns, G. S. (2004). Human striatal responses to monetary reward depend on saliency. Neuron, 42, 509517.

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Development and Psychopathology
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