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Neurodevelopmental factors associated with schizotypal symptoms among adolescents at risk for schizophrenia

  • Sydney L. Hans (a1), Judith G. Auerbach (a2), Keith H. Nuechterlein (a3), Robert F. Asarnow (a3), Joan Asarnow (a3), Benedict Styr (a4) and Joseph Marcus (a1)...
Abstract
Abstract

Schizophrenia has come to be viewed as a neurodevelopmental disorder that is characterized by genetic vulnerability, stressors during the prenatal period that may be marked by minor physical anomalies and neurobehavioral deficits that emerge in early development. Less is known about the neurodevelopmental origins of schizotypal personality symptoms. The present study examines schizotypal symptoms in Israeli adolescents (mean age = 16.79 years) who have not yet reached the developmental period during which first schizophrenic episode is most likely to emerge: 39 adolescent offspring of parents with schizophrenia, 39 offspring of parents with other psychiatric disorders, and 36 offspring of parents with no history of mental illness. The Semi-Structured Kiddie Interview for Personality Syndromes was used to assess cognitive–perceptual, interpersonal, and disorganized schizotypal symptoms. Interpersonal schizotypal symptoms were more prevalent in the schizophrenia offspring group than in the no-mental-illness offspring group. Among the schizophrenia offspring group, interpersonal, but not cognitive–perceptual, schizotypal symptoms were associated with minor physical anomalies, fine motor dyscoordination, and deficits in executive functioning during adolescence. Among young people whose parents did not have schizophrenia, cognitive–perceptual schizotypal symptoms were correlated with deficits in executive functioning. Adolescent schizotypal symptoms were associated with neurobehavioral symptoms measured during middle childhood in a subgroup of the sample that had been assessed prospectively. Finally, young people who had genetic risk for schizophrenia, minor physical anomalies, and neurobehavioral signs together were at markedly increased risk for symptoms of interpersonal schizotypal symptoms, compared to young people with one or none of these risk factors.

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Corresponding author
Address correspondence and reprint requests to: Sydney Hans, School of Social Service Administration, University of Chicago, 969 East 60th Street, Chicago, IL 60637; E-mail: shans@uchicago.edu.
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J. Angst , & P. Clayton (1986). Premorbid personalitiy of depressive, bipolar and schizophrenic patients with special reference to suicidal issues. Comprehensive Psychiatry, 27, 511532.

J. R. Asarnow , M. C. Tompson , & M. J. Goldstein (1994). Childhood-onset schizophrenia: A followup study. Schizophrenia Bulletin, 20, 599617.

R. F. Asarnow , K. H. Nuechterlein , K. L. Subotnik , D. L. Fogelson , R. D. Torquato , D. L. Payne , (2002). Neurocognitive impairments in nonpsychotic parents of children with schizophrenia and attention-deficit/hyperactivity disorder: The University of California, Los Angeles Family Study. Archives of General Psychiatry, 59, 10531060.

R. F. Asarnow , R. A. Steffy , D. J. MacCrimmon , & J. M. Cleghorn (1977). An attentional assessment of foster children at risk for schizophrenia. Journal of Abnormal Psychology, 86, 267274.

J. G. Auerbach , L. Erlenmeyer-Kimling , B. Fish , S. L. Hans , L. J. Ingraham , J. Marcus , (2009). Genetic risk for schizophrenia: Findings from the longitudinal high risk studies. In Y.-K. Kim (Ed.), Handbook of behavioral genetics. New York: Springer.

A. M. Bollini , M. T. Compton , M. L. Esterberg , J. Rutland , V. H. Chien , & E. F. Walker (2007). Associations between schizotypal features and indicators of neurological and morphological abnormalities. Schizophrenia Research, 92, 3240.

M. E. Calkins , C. E. Curtis , W. M. Grove , & W. G. Iacono (2004). Multiple dimensions of schizotypy in first degree relatives of schizophrenia patients. Schizophrenia Bulletin, 30, 317325.

G. A. Carlson , & B. Fish (2005). Longitudinal course of schizophrenia spectrum symptoms in offspring of psychiatrically hospitalized mothers. Journal of Child and Adolescent Psychopharmacology, 15, 362383.

L. J. Chapman , J. P. Chapman , T. R. Kwapil , M. Eckblad , & M. C. Zinser (1994). Putatively psychosis prone subjects ten years later. Journal of Abnormal Psychology, 103, 171183.

D. Cicchetti , & T. D. Cannon (1999). Neurodevelopmental processes in the ontogenesis and epigenesis of psychopathology. Development and Psychopathology, 11, 375393.

R. Condray , & S. R. Steinhauser (1992). Schizotypal personality disorder in individuals with and without schizophrenic relatives: Similarities and contrasts in neurocognitive and clinical functioning. Schizophrenia Research, 7, 3341.

C. Corcoran , E. Walker , R. Huot , V. Mittal , K. Tessner , L. P. Kestler , (2003). The stress cascade and schizophrenia: Etiology and onset. Schizophrenia Bulletin, 29, 671692.

B. Cornblatt , M. Obuchowski , S. Roberts , S. Pollack , & L Erlenmeyer-Kimling . (1999). Cognitive and behavioral precursors of schizophrenia. Development and Psychopathology, 11, 487508.

M. J. Cuesta , V. Peralta , & F. Caro (1999). Premorbid personality in psychoses. Schizophrenia Bulletin, 25, 801811.

Z. Delawalla , D. M. Barch , J. L. F. Eastep , E. S. Thomason , M. J. Hanewinkel , P. A. Thompson , (2006). Factors mediating cognitive deficits and psychopathology among siblings of individuals with schizophrenia. Schizophrenia Bulletin, 32, 525537.

D. Diforio , E. F. Walker , & L. P. Kestler (2000). Executive functions in adolescents with schizotypal personality disorder. Schizophrenia Research, 42, 125134.

W. M. Dinn , C. L. Harris , A. Aycicegi , P. Greene , & M. S. Andover (2002). Positive and negative schizotypy in a student sample: Neurocognitive and clinical correlates. Schizophrenia Research, 56, 171185.

R. H. Dworkin , B. A. Cornblatt , R. Friedmann , L. M. Kaplansky , J. A. Lewis , A. Rinaldi , (1993). Childhood precursors of affective vs. social deficits in adolescents at risk for schiozphrenia. Schizophrenia Bulletin, 19, 563577.

J. Endicott , & R. L. Spitzer (1972). Current and Past Psychopathology Scales (CAPPS): Rationale, reliability, and validity. Archives of General Psychiatry, 27, 678687.

L. Erlenmeyer-Kimling , D. Rock , S. A. Roberts , M. Janal , C. Kestenbaum , B. Cornblatt , (2000). Attention, memory, and motor skills as childhood predictors of schizophrenia-related psychoses: The New York High-Risk Project. American Journal of Psychiatry, 157, 14161422.

W. K. Estes , & H. A. Taylor (1966). Visual detection in relation to display size and redundancy of critical elements. Perception and Psychophysics, 1, 916.

B. Fish (1977). Neurobiologic antecedents of schizophrenia in children. Archives of General Psychiatry, 34, 12971313.

P. Franke , W. Maier , J. Hardt , C. Hain , & B. A. Cornblatt (1994). Attentional abilities and measures of schizotypy: Their variation and covariation in schizophrenic patients, their siblings, and normal control subjects. Psychiatry Research, 54, 259272.

D. C. Gooding , K. A. Tallent , & C. W. Matts (2005). Clinical status of at-risk individuals 5 years later: Further validation of the psychometric high-risk strategy. Journal of Abnormal Psychology, 114, 170175.

D. Gourion , C. Goldberger , M.-C. Bourdel , F. J. Bayle , H. Loo , & M.-O. Krebs (2004). Minor physical anomalies in patients with schizophrenia and their parents: Prevalence and pattern of craniofacial abnormalities. Psychiatry Research, 125, 2128.

D. Gourion , C. Goldberger , J. P. Olie , & M. O. Krebs (2004). Neurological and morphological anomalies and the genetic liability to schizophrenia: “A composite phenotype.” Schizophrenia Research, 67, 2331.

D. A. Grant , & E. A. Berg (1948). A behavioral analysis of degree of reinforcement and ease of shifting to new responses in a Weigl-type card-sorting problem. Journal of Experimental Psychology, 38, 404411.

M. F. Green , H. S. Bracha , P. Satz , & C. Christenson (1994). Preliminary evidence for an association between minor physical anomalies and second trimester neurodevelopment in schizophrenia. Psychiatry Research, 53, 119127.

M. F. Green , P. Satz , & C. Christenson (1994). Minor physical anomalies in schizophrenia patients, bipolar patients, and their siblings. Schizophrenia Bulletin, 20, 433440.

W. M. Grove , B. S. Lebow , B. A. Clementz , A. Cerri , C. Medus , & W. B. Iacono (1991). Familial prevalence and coaggregation of schizotypy indicators: A multitrait family study. Journal of Abnormal Psychology, 100, 115121.

J. G. Gunderson , L. J. Siever , & E. Spaulding (1983). The search for a schizotype. Archives of General Psychiatry, 40, 1522.

S. L. Hans , A. G. Auerbach , J. R. Asarnow , B. Styr , & J. Marcus (2000). Social adjustment of adolescents at risk for schizophrenia: The Jerusalem Infant Development Study. Journal of the American Academy of Child and Adolescent Psychiatry, 39, 14061414.

S. L. Hans , J. G. Auerbach , B. Styr , & J. Marcus (2004). Offspring of schizophrenic parents: Mental disorders during childhood and adolescence. Schizophrenia Bulletin, 30, 303315.

S. L. Hans , J. Marcus , K. H. Nuechterlein , R. F. Asarnow , B. Styr , & A. G. Auerbach (1999a). Neurobehavioral deficits at adolescence in children at risk for schizophrenia: The Jerusalem Infant Development Study. Archives of General Psychiatry, 56, 741748.

K. Hata , J. Iida , H. Iwasaka , H. Negoro , & T. Kishimoto (2003). Associations between minor physical anomalies and lateral ventricular enlargement in childhood and adolescent onset schizophrenia. Acta Psychiatrica Scandinavica, 108, 147151.

L. J. Ingraham , F. Chard , M. Wood , & A. F. Mirsky (1988). A Hebrew language version of the Stroop Test. Perceptual and Motor Skills, 67, 187192.

B. Ismail , E. Cantor-Graae , & T. F. McNeil (1998). Minor physical anomalies in schizophrenic patients and their siblings. American Journal of Psychiatry, 155, 16951702.

B. Ismail , E. Cantor-Graae , & T. F. McNeil (2000). Minor physical anomalies in schizophrenia: Cognitive, neurological and other clinical correlates. Journal of Psychiatric Research, 34, 4556.

P. Jones , B. Rodgers , R. Murray , & M. Marmot (1994). Child developmental risk factors for adult schizophrenia in the British 1946 birth cohort. Lancet, 344, 13981402.

K. Kendler , & S. R. Diehl (1993). The genetics of schizophrenia: A current genetic–epidemiological perspective. Schizophrenia Bulletin, 19, 263285.

K. S. Kendler , & C. O. Gardner (1997). The risk for psychiatric disorders in relatives of schizophrenic and control probands: A comparison of three independent studies. Psychological Medicine, 27, 411419.

K. S. Kendler , M. McGuire , A. M. Gruenberg , & D. Walsh (1995). Schizotypal symptoms and signs in the Roscommon Family Study: Their factor structure and familial relationship with psychotic and affective disorders. Archives of General Psychiatry, 52, 296303.

A. Laurent , M. Biloa-Tang , T. Bougerol , D. Duly , A.-M. Anchisi , J.-L. Bosson , (2000). Executive/attentional performance and measures of schizotypy in patients with schizophrenia and in their nonpsychotic first-degree relatives. Schizophrenia Research, 46, 269283.

S. M. Lawrie , M. Byrne , P. Miller , A. Hodges , R. A. Clafferty , D. G. C. Owens , (2001). Neurodevelopmental indices and the development of psychotic symptoms in subjects at high risk of schizophrenia. British Journal of Psychiatry, 178, 524530.

M. F. Lenzenweger , & L. Korfine (1994). Perceptual aberrations, schizotypy, and the Wisconsin Card Sorting Test. Schizophrenia Bulletin, 20, 345357.

M. J. Lyons , M. E. Merla , L. Young , & W. S. Kremen (1991). Impaired neuropsychological functioning in symptomatic volunteers with schizotypy: Preliminary findings. Biological Psychiatry, 30, 424426.

A. Malmberg , G. Lewis , A. David , & P. Allebeck (1998). Premorbid adjustment and personality in people with schizophrenia. British Journal of Psychiatry, 172, 308313.

J. Marcus , J. Auerbach , L. Wilkinson , & C. M. Burack (1981). Infants at risk for schizophrenia: The Jerusalem Infant Development Study. Archives of General Psychiatry, 38, 703713.

J. Marcus , S. Hans , B. Byhouwer , & J. Norem (1985). Relationships among neurological functioning, intelligence quotients and physical anomalies. Schizophrenia Bulletin, 11, 101106.

J. Marcus , S. L. Hans , J. G. Auerbach , & A. G. Auerbach (1993). Children at risk for schizophrenia: The Jerusalem Infant Development Study. II. Neurobehavioral deficits at school age. Archives of General Psychiatry, 50, 797809.

J. Marcus , S. L. Hans , E. Lewow , L. Wilkinson , & C. M. Burack (1985). Neurological findings in high-risk children: Childhood assessment and 5-year followup. Schizophrenia Bulletin, 11, 85100.

S. Marenco , & D. R. Weinberger (2000). The neurodevelopmental hypothesis of schizophrenia: Following a trail of evidence from cradle to grave. Development and Psychopathology, 12, 501527.

T. F. McNeil , & E. Cantor-Graae (2000). Neuromotor markers of risk for schizophrenia. Australian & New Zealand Journal of Psychiatry, 34(Suppl.), S86S90.

T. F. McNeil , B. Harty , G. Blennow , & E. Cantor-Graae (1993). Neuromotor deviation in offspring of psychotic mothers: A selective developmental deficiency in two groups of children at heightened psychiatric risk? Journal of Psychiatric Research, 27, 3954.

P. E. Meehl (1962). Schizotaxia, schizotypy, schizophrenia. American Psychologist, 17, 827838.

L. Mehlum , S. Friis , T. Irion , S. Johns , S. Karterud , P. Vaglum , (1991). Personality disorders 2–5 years after treatment: A prospective follow-up study. Acta Psychiatrica Scandinavica, 84, 7277.

P. Miller , M. Byrne , A. Hodges , S. M. Lawrie , D. B. Owens , & E. C. Johnstone (2002). Schizotypal components in people at high risk of developing schizophrenia: Early findings from the Edinburgh High-Risk Study. British Journal of Psychiatry, 180, 179184.

A. Mirsky (1987). Behavioral and psychophysiological markers of disordered attention. Environmental Health Perspectives, 74, 191199.

V. Mitropoulou , L. A. Harvey , L. A. Maldari , P. J. Moriarty , A. S. New , J. M. Silverman , (2002). Neuropsychological performance in schizotypal personality disorder: Evidence regarding diagnostic specificity. Biological Psychiatry, 52, 11751182.

V. A. Mittal , S. Dhruv , K. D. Tessner , D. J. Walder , & E. F. Walker (2007). The relations among putative biorisk markers in schizotypal adolescents: Minor physical anomalies, movement abnormalities, and salivary cortisol. Biological Psychiatry, 61, 11791186.

V. A. Mittal , K. D. Tessner , H. D. Trottman , M. Esterberg , S. H. Dhruv , D. I. Simeonova , (2007). Movement abnormalities and the progression of prodromal symptomatology in adolescents at risk for psychotic disorders. Journal of Abnormal Psychology, 116, 260267.

H. Noguchi , H. Hori , & H. Kunugi (2008). Schizotypal traits and cognitive function in healthy adults. Psychiatry Research, 161, 162169.

K. H. Nuechterlein (1983). Signal detection in vigilance tasks and behavioral attributes among offspring of schizophrenic mothers and among hyperactive children. Journal of Abnormal Psychology, 92, 428.

H. Orvaschel , S. Mednick , F. Schulsinger , & D. Rock (1979). The children of psychiatrically disturbed parents: Differences as a function of the sex of the sick parent. Archives of General Psychiatry, 36, 691695.

A. M. Poreh , T. P. Ross , & R. D. Whitman (1995). Reexamination of executive functions in psychosis-prone college students. Personality and Individual Differences, 18, 535539.

A. Raine (1991). The SPQ: A scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophrenia Bulletin, 17, 555564.

A. Raine (2006). Schizotypal personality: Neurodevelopmental and psychosocial trajectories. Annual Review of Clinical Psychology, 2, 291326.

R. M. Reitan (1958). Validity of the Trail-Making Test as an indicator of organic brain damage. Perceptual and Motor Skills, 8, 271276.

C. A. Reynolds , A. Raine , K. Mellingen , P. H. Venables , & S. A. Mednick (2000). Three-factor model of schizotypal personality: Invariance across culture, gender, religious affiliation, family adversity, and psychopathology. Schizophrenia Bulletin, 26, 603618.

H. E. Rosvold , A. F. Mirsky , I. Sarason , E. D. Bransome Jr., & L. H. Beck (1956). A continuous performance test of brain damage. Journal of Consulting Psychology, 20, 343350.

J. Rutschmann , B. Cornblatt , & L. Erlenmeyer-Kimling (1977). Sustained attention in children at risk for schizophrenia. Archives of General Psychiatry, 34, 571575.

J. Rutschmann , B. Cornblatt , & L. Erlenmeyer-Kimling (1986). Sustained attention in children at risk for schizophrenia: Findings with two visual continuous performance tests in a new sample. Journal of Abnormal Child Psychology, 14, 365385.

L. J. Siever , & K. L. Davis (2004). The pathophysiology of schizophrenia disorders: Perspectives from the spectrum. American Journal of Psychiatry, 161, 398413.

B. E. Snitz , A. W. MacDonald III, & C. S. Carter (2006). Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: A meta-analytic review of putative endophenotypes. Schizophrenia Bulletin, 32, 179194.

M. B. Spitznagel , & J. A. Suhr (2002). Executive function deficits associated with symptoms of schizotypy and obsessive-compulsive disorder. Psychiatry Research, 110, 151163.

E. Squires-Wheeler , D. Friedman , G. P. Amminger , A. Skodol , S. Looser-Ott , S. Roberts , (1997). Negative and positive dimensions of schizotypal personality disorder. Journal of Personality Disorders, 11, 285300.

E. Squires-Wheeler , A. Skodol , & L. Erlenmeyer-Kimling (1992). The assessment of schizotypal features over two points in time. Schizophrenia Research, 6, 7585.

J. R. Stroop (1935). Studies of interference in serial verbal reactions. Journal of Experimental Psychology, 18, 643662.

J. A. Suhr (1997). Executive functioning deficits in hypothetically psychosis-prone college students. Schizophrenia Research, 27, 2935.

P. Tienari , L. C. Wynne , K. Laksy , J. Moring , P. Nieminen , A. Sorri , (2003). Genetic boundaries of the schizophrenia spectrum: Evidence from the Finnish adoptive family study of schizophrenia. American Journal of Psychiatry, 160, 1587–1584.

R. L. Trestman , R. S. E. Keefe , V. Mitropoulou , P. D. Harvey , M. L. de Vegvar , S. Lees-Roitman , (1995). Cognitive function and biological correlates of cognitive performance in schizotypal personality disorder. Psychiatry Research, 59, 127136.

M. M. Voglmaier , L. J. Seidman , M. A. Niznikiewicz , C. C. Dickey , M. E. Shenton , & R. W. McCarley (2005). A comparative profile analysis of neuropsychological function in men and women with schizotypal personality disorder. Schizophrenia Research, 74, 4349.

M. M. Voglmaier , L. J. Seidman , D. Salisbury , & R. W. McCarley (1997). Neuropsychological dysfunction in schizotypal personality disorder: A profile analysis. Biological Psychiatry, 41, 530540.

M. G. Vollema , & B. Postma (2002). Neurocognitive correlates of schizotypy in first-degree relatives of schizophrenia patients. Schizophrenia Bulletin, 28, 367377.

J. L. Waddington , A. Lane , P. Scully , D. Meagher , J. Quinn , C. Larkin , (1999). Early cerebro-craniofacial dysmorphogenesis in schizophrenia: A lifetime trajectory model from neurodevelopmental basis to “neuroprogressive” process. Journal of Psychiatric Research, 33, 477489.

E. Walker , N. Lewis , R. Loewy , & S. Palyo (1999). Motor dysfunction and risk for schizophrenia. Development and Psychopathology, 11, 509523.

E. F. Walker (1991). Schizophrenia: A life-course developmental perspective. New York: Academic Press.

E. F. Walker , L. P. Kestler , A. M. Bollini , & K. M. Hochman (2004). Schizophrenia: Etiology and course. Annual Review of Psychology, 55, 401430.

E. F. Walker , C. B. Logan , & D. Walder (1999). Indicators of neurodevelopmental abnormality in schizotypal personality disorder. Psychiatric Annals, 29, 132136.

C. T. Webb , & D. F. Levinson (1993). Schizotypal and paranoid personality disorder in the relatives of patients with schizophrenia and affective disorders: A review. Schizophrenia Research, 11, 117137.

S. M. Weinberg , E. A. Jenkins , M. L. Marazita , & B. S. Maher (2007). Minor physical anomalies in schizophrenia: A meta-analysis. Schizophrenia Research, 89, 7285.

A. R. Yung , L. J. Phillips , H. P. Yuen , S. M. Francey , C. A. McFarlane , M. Hallgren , (2003). Psychosis predictions: 12-month follow up of a high-risk (“prodromal”) group. Schizophrenia Research, 60, 2132.

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