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The neurobiology of oppositional defiant disorder and conduct disorder: Altered functioning in three mental domains

  • Walter Matthys (a1) (a2), Louk J. M. J. Vanderschuren (a1) (a2) and Dennis J. L. G. Schutter (a2)
Abstract
Abstract

This review discusses neurobiological studies of oppositional defiant disorder and conduct disorder within the conceptual framework of three interrelated mental domains: punishment processing, reward processing, and cognitive control. First, impaired fear conditioning, reduced cortisol reactivity to stress, amygdala hyporeactivity to negative stimuli, and altered serotonin and noradrenaline neurotransmission suggest low punishment sensitivity, which may compromise the ability of children and adolescents to make associations between inappropriate behaviors and forthcoming punishments. Second, sympathetic nervous system hyporeactivity to incentives, low basal heart rate associated with sensation seeking, orbitofrontal cortex hyporeactiviy to reward, and altered dopamine functioning suggest a hyposensitivity to reward. The associated unpleasant emotional state may make children and adolescents prone to sensation-seeking behavior such as rule breaking, delinquency, and substance abuse. Third, impairments in executive functions, especially when motivational factors are involved, as well as structural deficits and impaired functioning of the paralimbic system encompassing the orbitofrontal and cingulate cortex, suggest impaired cognitive control over emotional behavior. In the discussion we argue that more insight into the neurobiology of oppositional defiance disorder and conduct disorder may be obtained by studying these disorders separately and by paying attention to the heterogeneity of symptoms within each disorder.

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Corresponding author
Address correspondence and reprint requests to: Walter Matthys, University Medical Center Utrecht, B01.324, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands; E-mail: w.matthys@umcutrecht.nl.
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M. aan het Rot , N. Coupland , D. B. Boivin , C. Benkelfat , & S. N. Young (2010). Recognizing emotions in faces: Effects of acute tryptophan depletion and bright light. Psychopharmacology, 24, 14471454.

A. Angold , J. E. Costello , & A. Erkanli (1999). Comorbidity. Journal of Child Psychology and Psychiatry, 40, 5787.

G. Aston-Jones , & J. D. Cohen (2005). An integrative theory of locus coeruleus–norepinephrine function: Adaptive gain and optimal performance. Annual Review of Neuroscience, 28, 403450.

B. W. Balleine , & S. Killcross (2006). Parallel incentive processing: An integral view of amygdala functioning. Trends in Neurosciences, 29, 272279.

R. J. Barry , A. R. Clarke , & S. J. Johnstone (2003). A review of electrophysiology in attention-deficit/hyperactivity disorder: I. Qualitative and quantitative electroencephalography. Clinical Neurophysiology, 114, 171183.

L. O. Bauer , & V. M. Hesselbrock (1999). Subtypes of family history and conduct disorder: Effects on P300 during the Stroop test. Neuropsychopharmacology, 21, 5162.

L. Baving , T. Rellum , M. Laucht , & M. H. Schmidt (2006). Children with oppositional–defiant disorder display deviant attentional processing independent of ADHD symptoms. Journal of Neural Transmission, 113, 685693.

T. P. Beachaine (2001). Vagal tone, development, and Gray's motivational theory: Toward an integrated model of autonomic nervous system functioning in psychopathology. Development and Psychopathology, 13, 183214.

A. Bechara , A. R. Damasio , H. Damasio , & S. W. Anderson (1994). Insensitivity to future consequences following damage to human prefrontal cortex. Cognition, 50, 715.

A. Bechara , S. Dolan , N. Denburg , A. Hindes , S. W. Anderson , & P. E. Nathan (2001). Decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers. Neuropsychologia, 39, 376389.

C. W. Berridge , & B. D. Waterhouse (2003). The locus coeruleus-noradrenergic system: Modulation of behavioral state and state-dependent cognitive processes. Brain Research Reviews, 42, 3384.

R. J. R. Blair (2007). Dysfunctions of medial and lateral orbitofrontal cortex in psychopathy. Annals of the New York Academy of Sciences, 1121, 461479.

J. W. Buckholtz , M. T. Treadway , R. L. Cowan , N. D. Woodward , S. D. Benning , R. Li , (2010). Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits. Nature Neuroscience, 13, 419421.

R. Bussing , J. Grudnik , D. Mason , M. Wasiak , & C. Leonard (2002). ADHD and conduct disorder: An MRI study in a community sample. World Journal of Biological Psychiatry, 3, 216220.

M. C. Cappadocia , M. Desrocher , D. Pepler , & J. H. Schroeder (2009). Contextualizing the neurobiology of conduct disorder in an emotion dysregulation framework. Clinical Psychological Review, 29, 506518.

A. Caspi , K. Langley , B. Milne , T. E. Moffitt , M. O'Donovan , M. Owen , (2008). A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry, 65, 203210.

S. R. Chamberlain , U. Müller , T. W. Robbins , & B. J. Sahakian (2006). Neuropharmacological modulation of cognition. Current Opinion in Neurology, 19, 607612.

D. F. Connor , S. Glatt , I. Lopez , D. Jackson , & R. Melloni (2002). Psychopharmacology and aggression. I. A meta analysis of stimulant effects on overt–covert aggression-related behaviors in ADHD. Journal of the American Academy of Child & Adolescent Psychiatry, 41, 253261.

R. Cools , A. J. Calder , A. D. Lawrence , L. Clark , E. Bullmore , & T. W. Robbins (2005). Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful faces. Psychopharmacology, 180, 670679.

R. Cools , A. C. Roberts , & T. W. Robbins (2008). Serotoninergic regulation of emotional and behavioural control processes. Trends in Cognitive Sciences, 12, 3140.

S. Crowell , T. P. Beauchaine , L. Gatzke-Kopp , P. Sylvers , H. Mead , & J. Chipman-Chacon (2006). Autonomic correlates of attention-deficit/hyperactivity disorder and oppositional defiant disorder in preschool children. Journal of Abnormal Psychology, 115, 174178.

J. W. Dalley , R. N. Cardinal , & T. W. Robbins (2004). Prefrontal executive and cognitive functions in rodents: Neural and neurochemical substrates. Neuroscience and Biobehavioral Reviews, 28, 771784.

S. A. De Brito , A. Mechelli , M. Wilke , K. R. Laurens , A. P. Jones , G. J. Barker , (2009). Size matters: Increased grey matter in boys with conduct problems and callous–unemotional traits. Brain, 132, 843852.

S. Durston , H. E. Hulshoff Pol , B. J. Casey , J. N. Giedd , J. K. Buitelaar , & H. van Engeland (2001). Anatomical MRI of the developing human brain: What have we learned? Journal of the American Academy of Child & Adolescent Psychiatry, 40, 21492157.

M. Ernst , S. J. Grant , E. D. London , C. S. Contoreggi , A. S. Kimes , & L. Spurgeon (2003). Decision making in adolescents with behaviour disorders and adults with substance abuse. American Journal of Psychiatry, 160, 3340.

G. Fairchild , S. H. M. van Goozen , S. J. Stollery , M. R. F. Aitken , J. Savage , S. C. Moore , (2009). Decision making and executive function in male adolescents with early-onset or adolescence-onset conduct disorder and control subjects. Biological Psychiatry, 66, 162168.

G. Fairchild , S. H. M. van Goozen , S. J. Stollery , & I. Goodyer (2008). Fear conditioning and affective modulation of the startle reflex in male adolescents with early-onset or adolescence onset conduct disorder and healthy control subjects. Biological Psychiatry, 63, 279285.

E. C. Finger , A. A. Marsh , K. S. Blair , M. E. Reid , C. Sims , P. Ng , (2011). Disrupted reinforcement signaling in the orbitofrontal cortex and caudate in youths with conduct disorder or oppositional defiant disorder and a high level of psychopathic traits. American Journal of Psychiatry, 168, 152162.

J. D. Flory , J. H. Newcorn , C. Miller , S. Harty , & J. Halperin (2007). Serotonergic function in children with attention-deficit hyperactivity disorder. British Journal of Psychiatry, 190, 410414.

D. L. Foley , L. J. Eaves , B. Wormley , J. L. Silberg , H. H. Maes , J. Kuhn , (2004). Childhood adversity, monoamine oxidase A genotype, and risk for conduct disorder. Archives of General Psychiatry, 61, 738744.

P. J. Frick , & S. F. White (2008). Research review: The importance of callous–unemotional traits for developmental models of aggressive and antisocial behavior. Journal of Child Psychology and Psychiatry, 49, 359375.

Y. Gao , A. Raine , P. H. Venables , M. E. Dawson , & S. A. Mednick (2010a). Reduced electrodermal fear conditioning from ages 3 to 8 years is associated with aggressive behaviour at age 8 years. Journal of Child Psychology and Psychiatry, 51, 550558.

Y. Gao , A Raine , P. H. Venables , M. E. Dawson , & S. A. Mednick (2010b). Association of poor childhood fear conditioning and adult crime. American Journal of Psychiatry, 167, 5660.

S. Grant , C. Contoreggi , & E. D. London (2000). Drug abusers show impaired performance in a laboratory test of decision-making. Neuropsychologia, 38, 11801187.

S. C. Herpertz , T. Huebner , I. Marx , T. Vloet , G. R. Fink , T. Stoecker , (2008). Emotional processing in male adolescents with childhood-onset conduct disorder. Journal of Child Psychology and Psychiatry, 49, 781791.

J. Holmes , A. Payton , J. Barrett , R. Harrington , P. McGuffin , M. Owen , (2002). Association of DRD4 in children with ADHD ad comorbid conduct problems. American Journal of Medical Genetics, 114, 150153.

D. Hoyer , J. P. Hannon , & G. R. Martin (2002). Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacology, Biochemistry, & Behavior, 71, 533554.

A. P. Jones , K. R. Laurens , C. J. Herba , & E. Viding (2009). Amygdala hypoactivity to fearful faces in boys with conduct problems and callous–unemotional traits. American Journal of Psychiatry, 166, 95102.

R. J. Houston , & M. S. Stanford (2005). Electrophysiological substrates of impulsiveness: Potential effects on aggressive behavior. Progress in Neuropsychopharmacology and Biological Psychiatry, 29, 305313.

R. G. Klein , H. Abikoff , E. Klass , D. Ganales , L. M. Seese , & S. Pollack (1997). Clinical efficacy of methylphenidate in conduct disorder with and without attention deficit hyperactivity disorder. Archives of General Psychiatry, 54, 10731080.

M. J. P. Kruesi , M. F. Casanova , G. Mannheim , & A. Johnson-Bilder (2004). Reduced temporal lobe volume in early onset conduct disorder. Psychiatry Research: Neuroimaging, 132, 111.

M. J. P. Kruesi , J. L. Rapaport , S. Hamburger , E. Hibbs , W. Z. E. Potter , M. Lenane , (1990). Cerebrospinal fluid monoamine metabolites, aggression, and impulsivity in disruptive behavior disorders of children and adolescents. Archives of General Psychiatry, 47, 419426.

M. Luman , J. S Sergeant , D. Knol , & J. Oosterlaan (2010). Impaired decision making in oppositional defiant disorder related to altered psychophysiological responses to reinforcement. Biological Psychiatry, 68, 337343.

D. T. Lykken (1957). A study of anxiety in the sociopathic personality. Journal of Abnormal and Social Psychology, 55, 610.

A. A. Marsh , E. C. Finger , D. G. V. Mitchell , M. Reid , C. Sims , D. S. Kosson , (2008). Reduced amygdala response to fearful expressions in children and adolescents with callous–unemotional traits and disruptive behaviour disorders. American Journal of Psychiatry, 165, 712720.

W. Matthys , S. H. M. van Goozen , H. de Vries , P. Cohen-Kettenis , & H. van Engeland (1998). The dominance of behavioural activation over behavioural inhibition in conduct disordered boys with and without attention deficit hyperactivity disorder. Journal of Child Psychology and Psychiatry, 39, 643651.

W. Matthys , S. H. M. van Goozen , H. Snoek , & H. van Engeland (2004). Response perseveration and sensitivity to reward and punishment in boys with oppositional defiant disorder. European Child and Adolescent Psychiatry, 13, 362364.

R. J. Nelson , & B. C. Trainer (2007). Neural mechanisms of aggression. Nature Review of Neuroscience, 8, 536546.

J. H. Newcorn , T. J. Spencer , J. Biederman , D. R. Milton , & D. Michelson (2005). Atomoxetine treatment in children and adolescents with attention deficit/hyperactivity disorder and comorbid oppositional defiant disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 44, 240248.

M. K. Nock , A. E. Kazdin , E. Hiripi , & R. C. Kessler (2007). Lifetime prevalence, correlates, and persistence of oppositional defiant disorder: Results from the national Comorbidity Survey Replication. Journal of Child Psychology and Psychiatry, 48, 703713.

B. S. O'Brien , & P. J. Frick (1996). Reward dominance: Associations with anxiety, conduct problems, and psychopathy in children. Journal of Abnormal Child Psychology, 24, 223240.

J. Oosterlaan , G. D. Logan , & J. A. Sergeant (1998). Response inhibition in AD/HD, CD, comorbid AD/HD + CD, anxious and normal children: A meta-analysis of studies with the stop task. Journal of Child Psychology and Psychiatry, 39, 411426.

D. A. Pardini , P. J. Frick , & T. E. Moffitt (2010). Building an evidence base for DSM-5 conceptualizations of oppositional defiant and conduct disorder: Introduction to the special section. Journal of Abnormal Psychology, 119, 683686.

B. F. Pennington , & S. Ozonoff (1996). Executive functions and developmental psychopathology. Journal of Child Psychology and Psychiatry, 37, 5187.

E. A. Phelps , & J. E. LeDoux (2005). Contributions of the amygdala to emotion processing: From animal models to human behavior. Neuron, 48, 175187.

J. A. Posthumus , K. B. E. Böcker , M. A. J. Raaijmakers , H. van Engeland , & W. Matthys (2009). Heart rate and skin conductance in 4-year old children with aggressive behavior. Biological Psychology, 82, 164168.

H. C. Quay (1965). Psychopathic personality as pathological stimulation-seeking. American Journal of Psychiatry, 122, 180183.

M. A. J. Raaijmakers , D. P. Smidts , J. A. Sergeant , G. H. Maassen , J. A. Posthumus , H. van Engeland , (2008). Executive functions in preschool children with aggressive behavior: Impairments in inhibitory control. Journal of Abnormal Child Psychology, 36, 10971107.

T. W. Robbins , & A. F. T. Arnsten (2009). The neuropsychopharmacology of fronto-executive function: Monoaminergic modulation. Annual Review of Neuroscience, 32, 267287.

G. A. Rogeness , M. A. Javors , J. W. Maas , & C. A. Macedo (1990). Catecholamines and diagnoses in children. Journal of the American Academy of Child & Adolescent Psychiatry, 29, 234241.

R. D. Rogers , B. J. Everitt , A. Baldacchino , A. J. Blackshaw , R. Swainson , K. Wynne , (1999). Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: Evidence for monoaminergic mechanisms. Neuropsychopharmacology, 20, 322339.

E. T. Rolls (2004). The functions of the orbitofrontal cortex. Brain and Cognition, 55, 1129.

K. Rubia , R. Halari , A. Smith , M. Mohammed , S. Scott , & M. J. Brammer (2009). Shared and disorder-specific prefrontal abnormalities in boys with pure attention-deficit/hyperactivity disorder compared to boys with pure CD during interference inhibition and attention allocation. Journal of Child Psychology and Psychiatry, 50, 669678.

K. Rubia , A. B. Smith , R. Halari , F. Matsukara , M. Mohammad , E. Taylor , (2009). Disorder-specific dissociation of orbitofrontal dysfunction in boys with pure conduct disorder during reward and ventrolateral prefrontal dysfunction in boys with pure ADHD during sustained attention. American Journal of Psychiatry, 166, 8394.

D. Sander , J. Grafman , & T. Zalla (2003). The human amygdala: An evolved system for relevance detection. Review of Neurosciences, 14, 303316.

K. P. Schultz , J. H. Newcorn , K. E. McKay , J. Himelstein , V. H. Koda , L. J. Siever , (2001). Relationship between serotonergic function and aggression in prepubertal boys: Effect of age and attention-deficit/hyperactivity disorder. Psychiatry Research, 101, 110.

D. J. L. G. Schutter , I. van Bokhoven , L. J. M. J. Vanderschuren , J. E. Lochman , & W. Matthys (2011). Risky decision making in substance dependent adolescents with a disruptive behavior disorder. Journal of Abnormal Child Psychology, 39, 333339.

D. J. L. G. Schutter , & J. van Honk (2005). The cerebellum on the rise in humane motion. Cerebellum, 4, 290294.

S. K. Shapiro , H. C. Quay , A. E. Hogan , & K. P. Schwartz (1988). Response perseveration and delayed responding in undersocialized aggressive conduct disorder. Journal of Abnormal Psychology, 97, 371373.

L. J. Siever (2008). Neurobiology of aggression and violence. American Journal of Psychiatry, 165, 429442.

J. J. Sijtsema , R. Veenstra , S. Lindenberg , A. M. van Roon , F. C. Verhulst , J. Ormel , (2010). Mediation of senstation seeking and behavioral inhibition on the relationship between heart rate and antisocial behaviour: The TRAILS study. Journal of the American Academy of Child & Adolescent Psychiatry, 49, 493502.

H. Snoek , S. H. M. van Goozen , W. Matthys , Buitelaar J. K., & H. van Engeland (2004). Stress responsivity in children with externalizing behavior disorders. Development and Psychopathology, 16, 389406.

H. Snoek , S. H. M. van Goozen , W. Matthys , H. O. Sigling , H. P. F. Koppeschaar , H. G. M. Westenberg , (2002). Serotonergic functioning in children with oppositional defiant disorder: A sumatriptan challenge study. Biological Psychiatry, 51, 319325.

C. Stadler , P. Sterzer , K. Schmeck , A. Krebs , A. Kleinschmidt , & F. Poustka (2007). Reduced anterior cingulate activation in aggressive children and adolescents during affective stimulation: Association with temperament traits. Journal of Psychiatric Research, 41, 410417.

P. Sterzer , C. Stadler , A. Krebs , A. Kleinschmidt , & F. Poustka (2005). Abnormal neural responses to emotional stimuli in adolescents with conduct disorder. Biological Psychiatry, 57, 715.

P. Sterzer , C. Stadler , F. Poustka , & A. Kleinschmidt (2007). A structural neural deficit in adolescents with conduct disorder and its association with lack of empathy. NeuroImage, 37, 335342.

A. Stringaris , & R. Goodman (2009a). Longitudinal outcome of youth oppositionality: Irritable, headstrong, and hurtful behaviors have distinctive predictions. Journal of the American Academy of Child & Adolescent Psychiatry, 48, 404412.

A. Stringaris , & R. Goodman (2009b). Three dimensions of oppositionality in youth. Journal of Child Psychology & Psychiatry, 50, 216223.

I van Bokhoven , W. Matthys , S. H. M. van Goozen , & H. van Engeland (2005). Prediction of adolescent outcome in children with disruptive behaviour disorders: A study of neurobiological, psychological and family factors. European Child and Adolescent Psychiatry, 14, 153163.

E. J. M. van der Vegt , B. A. Oostra , A. Arias-Vàsquez , J. van der Ende , F. C. Verhulst , & H. Tiemeier (2009). High activity of monoamine oxidase A is associated with externalizing behaviour in maltreated and nonmaltreated adoptees. Psychiatric Genetics, 19, 209211.

S. H. M. van Goozen , P. T. Cohen-Kettenis , H. Snoek , W. Matthys , H. Swaab-Barneveld , & H. van Engeland (2004). Executive functioning in children: A comparison of hospitalized ODD and ODD/ADHD children and normal controls. Journal of Child Psycholology and Psychiatry, 45, 284292.

S. H. M. van Goozen , & G. Fairchild (2008). How can the study of biological processes help design new interventions for children with severe antisocial behavior? Development and Psychopathology, 20, 941973.

S. H. M. van Goozen , G. Fairchild , H. Snoek , & G. T. Harold (2007). The evidence of a neurobiological model of childhood antisocial behavior. Psychological Bulletin, 133, 149182.

S. H. M. van Goozen , W. Matthys , P. T. Cohen-Kettenis , J. K. Buitelaar , & H. van Engeland (2000). Hypothylamic–pituitary–adrenal axis and autonomic nervous system activity in disruptive children and matched controls. Journal of the American Academy of Child & Adolescent Psychiatry, 39, 14381445.

S. H. M. van Goozen , W. Matthys , P. T. Cohen-Kettenis , C. Gispen-de Wied , V. M. Wiegant , & H. van Engeland (1998). Salivary cortisol and cardiovascular activity during stress in oppositional-defiant disorder boys and normal controls. Biological Psychiatry, 43, 531539.

N. D. Volkow , G. J. Wang , J. S. Fowler , F. Telang , L. Maynard , J. Logan , (2004). Evidence that methylphenidate enhances saliency of a mathematical task by increasing dopamine in the human brain. American Journal of Psychiatry, 161, 11731180.

P. Voorn , L. J. M. J. Vanderschuren , H. J. Groenewegen , T. W. Robbins , & C. M. A. Pennartz (2004). Putting a spin on the dorsal-ventral divide of the striatum. Trends in Neurosciences, 27, 468474.

G. Winterer , & D. Goldman (2003). Genetics of human prefrontal function. Brain Research Review, 43, 134163.

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