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Antibiotic-resistant pneumococci in hospitalized children

  • R. M. Robins-Browne (a1), Ayesha B. M. Kharsany (a1) and H. J. Koornhof (a2)

A search for nasopharyngeal carriers of Streptococcus pneumoniae was conducted in 573 children hospitalized in Durban, South Africa. Study subjects were divided into two groups, comprising 305 new admissions and 268 patients who had been hospitalized for more than 24 h. Of the 573 children 178(31%) yielded pneumococci on nasopharyngeal culture; 99 (32%) and 79 (29%) children in the new admission and in-patient categories respectively. Twenty-one (12%) pneumococci were resistant to penicillin, including 11 strains that were resistant to more than one antibiotic. Resistant pneumoeoeei belonged exclusively to serotypes 6 and 19 (Danish nomenclature), which were also the commonest serotypes among penicillin-sensitive strains. Factors that correlated with carriage of penicillin-resistant Pneumococci were hospitalization for more than 24 h, young age and recent exposure to beta-lactam antibiotics.

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Appelbaum P. C., A. Bhamjee, Scragg J. N.. Hallet A. F., Bowen A. J. & Cooper R. C. (1977). Streptococcus pneumoniae resistant to penicillin and ehloramphenieol. Lancet ii, 995997.
Armitage P. (1971). Statistical Methods in Medical Research. Oxford: Blackwell Scientific Publications.
Cowan M. J., Ammann A. J., Wara D. W., Howie V. M., Schultz L., Doyle N. & Kaplan M. (1978). Pneumococcal polvsaeehuride immunization in infants and children. Pediatrics 62. 721727.
Facklam R. R. (1980). Streptococci and aerococci. In Manual of Clinical Microbiology, 3rd ed. (ed. Lennette E. H., Balows A., Hausler W. J. and Truant J. P.), pp. 88110. Washington, D.C: American Society for Microbiology.
Gray B. M., Converse G. M. III & Dillon H. C Jr, (1980). Epidemiologic studies of Streptococcus pneumoniae in infants: acquisition, carriage, and infection during the first 24 months of life. Journal of Infectious Diseases 142, 923933.
Gray B. M., Converse G. M. III, Huhta N., Johnston R. B. Jr, Pichichero M. E., Shiffman G. & Dillon H. C. Jr, (1981). Epidemiologic studies ofStreptococcus pneumoniae in infants: antibody response to nasopharyngeal carriage of type 3, 19, and 23. Journal of Infectiotis Diseases 144, 312318.
Jacobs M. R., Koornhof H. J., Robins-Browne R. M., Stevenson C. M., Vermaak Z. A., Freiman I., Miller G. B., Witcomb M., Isaacson M., Ward J. I. & Austrian R. (1978). Emergence of multiply resistant pneumococci. New England Journal of Medicine 299, 735740.
Jacobs M. R., Mithal Y., Robins-Browne R. M., Gaspar M. N. & Koornhof H. J. (1979). Antimicrobial susceptibility testing of pneumococci: determination of Kirby-Bauer breakpoints for penicillin G, erythromycin, clindamycin, tetracycline, chloramphenicol, and rifampicin. Antimicrobial Agents and Chemotherapy 16, 190197.
Klein J. O. (1981). The epidemiology of pneumococcal disease in infants and children, Reviews of Infectious Diseases 3, 246253.
Koornhof H. J., Jacobs M., Isaacson M., Appelbaum P., Miller B., Stevenson C. M., Freiman I., Naude A., Botha P., Glathaar E. & Gilliland J. (1978). Follow-up on multiple-antibiotic-resistant pneumococci – South Africa. Morbidity and Mortality Weekly Report 27, 17.
Koornhof H. J., Jacobs M. R., Ward J. I., Appelbaum P. C. & Hallet A. F. (1979). Therapy and control of antibiotic-resistant pneumococcal disease. In Microbiology 1979 (ed. Schlesinger D.), pp. 286289. Washington, D.C.: American Society for Microbiology.
Loda F. A., Collier A. M., Glezen W. P., Strangert K., Clyde W. A. & Denny F. W. (1975). Occurrence of Diplococcus pneumoniae in the upper respiratory tract of children. Journal of Pediatrics 87, 10871093.
Mäkelä P. H., Sibakov M., Herva E., Henrichsen J., Luotonen J., Timonen M., Leinonen M., Koskela M., Pukander J., Pöntynen S., Grönroos P. & Karma P. (1980). Pneumococcal vaccine and otitis media. Lancet ii, 547551.
Mufson M. A. (1981). Pneumococcal infections. Journal of the American Medical Association 246, 19421948.
Radetsky M. S., Istre G. R., Johansen T. L., Parmelee S. W., Lauer B. A., Wiesenthal A. M. & Glode M. P. (1981). Multiply resistant pneumococcus causing meningitis: its epidemiology within a day-care centre. Lancet ii, 771773.
Robins-Browne R. M., Kharsany A. B. M. & Ramsaroop U. G. (1982). Detection of pneumococci in the upper repiratory tract: comparison of media and culture techniques. Journal of Clinical Microbiology 16, 13.
Saah A. J., Mallonee J. P., Tarpay M., Thornsberry C. T., Roberts M. A. & Rhoades E. R. (1980). Relative resistance to penicillin in the pneumococcus. A prevalence and case-control study. Journal of the American Medical Association 243, 18241827.
Siegel S. (1956). Nonparametric Statisticsfor the Behavioural Sciences. New York: McGraw Hill.
Ward J. (1981). Antibiotic-resistant Streptococcus pneumoniae: clinical and epidemiologic aspects. Reviews of Infectious Diseases 3, 254266.
Ward J. I., Koornhof H., Jacobs M. & Appelbaum P. (1979). Clinical and epidemiological features of multiply resistant pneumococci, South Africa. In Microbiology 1979 (ed. Schlesinger D.), pp. 283285. Washington, D.C.: American Society for Microbiology.
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
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