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Antigenic differences between vaccine and circulating wild-type mumps viruses decreases neutralization capacity of vaccine-induced antibodies

  • M. ŠANTAK (a1), M. LANG-BALIJA (a2), J. IVANCIC-JELECKI (a1), T. KOŠUTIĆ-GULIJA (a1), S. LJUBIN-STERNAK (a3) and D. FORCIC (a1)
  • DOI: http://dx.doi.org/10.1017/S0950268812001896
  • Published online: 07 September 2012
Abstract
SUMMARY

A recent resurgence of mumps in doubly vaccinated cohorts has been observed, identifying genotype G as the current predominant genotype. In this study, the neutralization efficacy of guinea pig sera immunized with three vaccine viruses: L-Zagreb, Urabe AM9 and JL5, was tested against seven mumps viruses: three vaccine strains and four wild-type strains (two of genotype G, one of genotype C, one of genotype D) isolated during 1998–2011. All sera neutralized all viruses although at different levels. The neutralization efficiency of sera decreases several fold by temporal order of virus isolation. Therefore, we concluded that gradual evolution of mumps viruses, rather than belonging to a certain genotype, results in an antigenic divergence from the vaccine strains that decrease the neutralization capacity of vaccine-induced antibodies. Moreover, the amino-acid sequence alignment revealed three new potentially relevant regions for escape from neutralization, i.e. 113–130, 375–403 and 440–443.

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Corresponding author
*Author for correspondence: M. Šantak, Ph.D., Institute of Immunology, Molecular Biomedicine Unit, Department for Research and Development, Rockefellerova 10, CRO-10000 Zagreb, Croatia. (Email: msantak@imz.hr)
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3.GH Dayan , Recent resurgence of mumps in the United States. New England Journal of Medicine 2008; 358: 15801589.

7.JE Echevarría , Circulation of mumps virus genotypes in Spain from 1996 to 2007. Journal of Clinical Microbiology 2010; 48: 12451254.

11.H Peltola , Mumps outbreaks in Canada and the United States: time for new thinking on mumps vaccines. Clinical Infectious Diseases 2007; 45: 459466.

12.JP Gut , Symptomatic mumps virus reinfections. Journal of Medical Virology 1995; 45: 1723.

15.M Šantak , Mumps virus strains isolated in Croatia in 1998 and 2005: genotyping and putative antigenic relatedness to vaccine strains. Journal of Medical Virology 2006; 78: 638643.

21.D Forcic , Comparisons of mumps virus potency estimates obtained by 50% cell culture infective dose assay and plaque assay. Vaccine 2010; 28: 18871892.

22.G Cross . Hemagglutination inhibition assay. Seminars in Avian and Exotic Pet Medicine 2002; 11: 1518.

23.BJ Cohen , Plaque reduction neutralization test for measles antibodies: description of a standardised laboratory method for use in immunogenicity studies of aerosol vaccination. Vaccine 2007; 26: 5966.

24.G Perrière , M Gouy . WWW-Query: an online retrieval system for biological sequence banks. Biochimie 1996; 78: 364369.

25.SA Plotkin . Correlates of protection induced by vaccination. Clinical and Vaccine Immunology 2010; 17: 10551065.

26.R Allwinn , Assessment of mumps virus-specific antibodies by different serological assays: which test correlates best with mumps immunity? European Journal of Clinical Microbiology and Infectious Diseases 2011; 30: 12231228.

27.J Kovamees , Hemagglutinin-neuraminidase (HN) amino acid alterations in neutralization escape mutants of Kilham mumps virus. Virus Research 1990; 17: 119129.

29.MG Cusi , Localization of a new neutralizing epitope on the mumps virus hemagglutinin-neuraminidase protein. Virus Research 2001; 74: 133137.

30.S Rubin , Serological and phylogenetic evidence of monotypic immune responses to different mumps virus strains. Vaccine 2006; 24: 26622668.

32.D Kay , Mumps outbreaks in four universities in the North West of England: prevention, detection and response. Vaccine 2011; 29: 38833887.

33.K Cantell . Mumps virus. Advances in Virus Research 1961; 8: 123164.

35.AA Date , Long-term persistence of mumps antibody after receipt of 2 measles-mumps-rubella (MMR) vaccinations and antibody response after a third MMR vaccination among a university population. Journal of Infectious Diseases 2008; 197: 16621668.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
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