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Changing species distribution and antimicrobial susceptibility pattern of Shigella over a 29-year period (1980–2008)

  • F. KHATUN (a1), A. S. G. FARUQUE (a1), J. L. KOECK (a2) (a3), P. OLLIARO (a4), P. MILLET (a2), N. PARIS (a5), M. A. MALEK (a1), M. A. SALAM (a1) and S. LUBY (a1)
  • DOI:
  • Published online: 18 May 2010

We studied changes in species distribution and antimicrobial resistance patterns of Shigella during 1980–2008, using the Diarrhoeal Diseases Surveillance system of Dhaka Hospital of ICDDR,B. In hospitalized patients Shigella prevalence decreased steadily from 8–12% in the 1980s to 3% in 2008. Endemic S. flexneri was the most commonly isolated species (54%). Epidemic S. dysenteriae type 1 had two peaks in 1984 and 1993, but was not found after 2000, except for one case in 2004. The therapeutic options are now limited: in 2008 a total of 33% of S. flexneri were resistant to ciprofloxacin and 57% to mecillinam. In the <5 years age group, severely underweight, wasted and stunted children were more at risk of shigellosis compared to well-nourished children (P<0·001). Although hospitalization for Shigella diarrhoea is decreasing, the high levels of antimicrobial resistance and increased susceptibility of malnourished children continue to pose an ongoing risk.

Corresponding author
*Author for correspondence: F. Khatun, MBBS, M.Sc., Public Health Sciences Division, ICDDR,B, 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka-1212, Bangladesh. (Email:
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2.L Von Seidlein , A multicentre study of Shigella diarrhoea in six Asian countries: disease burden, clinical manifestations, and microbiology. PLoS Medicine 2006; 3: e353.

4.ML Bennish . Potentially lethal complications of shigellosis. Review of Infectious Diseases 1991; 13: S319–324.

5.ML Bennish , BJ Wojtyniak . Mortality due to shigellosis: community and hospital data. Review of Infectious Diseases 1991; 13: S245–251.

6.SS Islam , NS Shahid . Morbidity and mortality in a diarrhoeal diseases hospital in Bangladesh. Transactions of the Royal Society of Tropical Medicine and Hygiene 1986; 80: 748752.

8.MM Rahaman , An outbreak of dysentery caused by Shigella dysenteriae type 1 on a coral island in the Bay of Bengal. Journal of Infectious Diseases 1975; 132: 1519.

14.D Cutler , G Miller . The role of public health improvements in health advances: the twentieth-century United States. Demography 2005; 42: 122.

17.S Hossain , Single dose vitamin A treatment in acute shigellosis in Bangladesh children: randomised double blind controlled trial. British Medical Journal 1999; 316: 422426.

21.A Naheed , Fluoroquinolone-resistant Shigella dysenteriae type 1 in northeastern Bangladesh. Lancet Infectious Diseases 2004; 4: 607608.

23.K Sarkar , Shigella dysenteriae type 1 with reduced susceptibility to fluoroquinolones. Lancet 2003; 361: 785.

25.M Rahman , Detection of 4-quinolone resistance mutation in gyrA gene of Shigella dysenteriae type 1 by PCR. Antimicrobial Agents and Chemotherapy 1994: 38: 24882491.

26.WA Khan , Treatment of shigellosis: V. Comparison of azithromycin and ciprofloxacin. A double-blind, randomized, controlled trial. Annals of Internal Medicine 1997; 126: 697703.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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