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Correlation between electrophoretic types B1 and B2 of carboxylesterase B and host-dependent factors in Escherichia coli septicaemia

Published online by Cambridge University Press:  19 October 2009

B. Picard  and
Ph. Goullet
B. Picard
Affiliation:
Service de Microbiologie, Hôpital Beaujon (Centre Hospitalier Universitaire Bichat-Beaujon, Université Paris VII), 100 boulevard du Général Leclerc, 92110 Clichy, France
Ph. Goullet
Affiliation:
Service de Microbiologie, Hôpital Beaujon (Centre Hospitalier Universitaire Bichat-Beaujon, Université Paris VII), 100 boulevard du Général Leclerc, 92110 Clichy, France
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Electrophoretic types B1 and B2 of carboxylesterase B produced by strains of Escherichia coli isolated from 100 septicaemia cases were correlated with α-haemolysin and mannose resistant haemagglutinin (MRHA) production and with clinical data including eventual underlying diseases, origin of septicaemia and evolution. Electrophoretic type B2 was phenotypically linked with α-haemolysin and MRHA production. The proportion of type B2 isolates varied significantly with occurrence of an underlying illness (45% for patients without an underlying disease and 22% for compromised patients) and with the site of origin of the septicaemia (40% for those of urinary origin and 18% for infection of digestive origin). In the former infections, type B2 isolates were obtained in the majority from male patients while type B1 isolates predominated in women. The septicaemias associated with type B1 were characterized by a lower proportion of isolates producing α-haemolysin and MRHA and by a greater frequency of septic shock and death than those associated with type B2. These facts emphasize the importance of host-dependent factors in E. coli septicaemia.

Type
Research Article
Information
Epidemiology & Infection , Volume 100 , Issue 1 , February 1988 , pp. 51 - 61
Copyright
Copyright © Cambridge University Press 1988

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