Skip to main content
×
Home
    • Aa
    • Aa

Assessing spatiotemporal patterns of multidrug-resistant and drug-sensitive tuberculosis in a South American setting

  • H. LIN (a1) (a2) (a3), S. SHIN (a1) (a4) (a5), J. A. BLAYA (a5) (a6), Z. ZHANG (a1), P. CEGIELSKI (a7), C. CONTRERAS (a8), L. ASENCIOS (a9), C. BONILLA (a10), J. BAYONA (a1) (a8) (a11), C. J. PACIOREK (a12) (a13) and T. COHEN (a1) (a14)...
Abstract
SUMMARY

We examined the spatiotemporal distribution of laboratory-confirmed multidrug-resistant tuberculosis (MDR TB) cases and that of other TB cases in Lima, Peru with the aim of identifying mechanisms responsible for the rise of MDR TB in an urban setting. All incident cases of TB in two districts of Lima, Peru during 2005–2007 were included. The spatiotemporal distributions of MDR cases and other TB cases were compared with Ripley's K statistic. Of 11 711 notified cases, 1187 received drug susceptibility testing and 376 were found to be MDR. Spatial aggregation of patients with confirmed MDR disease appeared similar to that of other patients in 2005 and 2006; however, in 2007, cases with confirmed MDR disease were found to be more tightly grouped. Subgroup analysis suggests the appearance of resistance may be driven by increased transmission. Interventions should aim to reduce the infectious duration for those with drug-resistant disease and improve infection control.

Copyright
Corresponding author
*Author for correspondence: T. Cohen, MD, DrPH, 641 Huntington Avenue, Boston, MA 02115, USA. (Email: tcohen@hsph.harvard.edu)
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Type Description Title
WORD
Supplementary Materials

Lin Supplementary Material
Figure Legends.doc

 Word (26 KB)
26 KB
WORD
Supplementary Materials

Lin Supplementary Material
Document_01.doc

 Word (49 KB)
49 KB
UNKNOWN
Supplementary Materials

Lin Supplementary Material
Figure_S01.tif

 Unknown (1.3 MB)
1.3 MB
UNKNOWN
Supplementary Materials

Lin Supplementary Material
Figure_S02.tif

 Unknown (1.3 MB)
1.3 MB

Metrics

Full text views

Total number of HTML views: 1
Total number of PDF views: 17 *
Loading metrics...

Abstract views

Total abstract views: 110 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 26th March 2017. This data will be updated every 24 hours.