Skip to main content
×
Home
    • Aa
    • Aa

Impact of Haemophilus influenzae type b vaccination on the incidence of invasive Haemophilus influenzae disease in France, 15 years after its introduction

  • S. GEORGES (a1), A. LEPOUTRE (a1), H. DABERNAT (a2) and D. LEVY-BRUHL (a1)
Abstract
SUMMARY

We assessed the impact of Haemophilus influenzae type b (Hib) vaccination, introduced in France in early 1993, on the incidence of invasive Haemophilus influenzae (Hi) disease up to 2008. The incidence of Hi meningitis fell from 0·9/100 000 in 1991–1992 to 0·09/100 000 in 1996–2008, with a marked decline (96%) in children aged <5 years, including infants aged <3 months, from 12 to 0·4/100 000. The incidence of invasive Hi disease also decreased in children aged <15 years from 6 to 0·7/100 000, remained stable in the 15–64 years age group at about 0·5/100 000, and increased slightly from 2·0 to 2·4/100 000 in persons aged >64 years. No emergence of non-encapsulated or encapsulated non-vaccine serotypes was observed. These findings confirm the major direct impact of Hib vaccination on the incidence of Hi invasive disease in children and the indirect benefit of vaccination for infants too young to be vaccinated.

Copyright
Corresponding author
*Author for correspondence: Dr D. Levy-Bruhl, Institut de Veille Sanitaire, 12 rue du Val d'Osne, 94410, Saint Maurice, France. (Email: d.levybruhl@invs.sante.fr)
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1. MDDecker , Comparative trial in infants of four conjugate Haemophilus influenzae type b vaccines. Journal of Pediatrics 1992; 120: 184189.

2.H Peltola , T Kilpi , M Anttila . Rapid disappearance of Haemophilus influenzae type b meningitis after routine childhood immunisation with conjugate vaccines. Lancet 1992; 340: 592594.

9.H Dabernat , Bacterial meningitis in France. Study in 6 mainland districts in 1995–1997. Medecine et Maladies Infectieuses 2000; 30: 588594.

10.H Dabernat , C Delmas . Activities of the National Reference Centre for Haemophilus influenzae, 1994–1995. First post-vaccination years. Medecine et Maladies Infectieuses 1996; 26: 698703.

11.H Dabernat , C Delmas . Activities of the National Reference Centre for Haemophilus influenzae, 1996–1997: The decline of the b type. Medecine et Maladies Infectieuses 1998; 28: 940946.

12.H Dabernat , Genotyping of type b Haemophilus influenzae strains, comparison of strains collected before and during vaccine availability. Medecine et Maladies Infectieuses 2005; 35: 205212.

15.SN Ladhani . Two decades of experience with the Haemophilus influenzae serotype b conjugate vaccine in the United Kingdom. Clinical Therapeutics Journal. 2012; 34: 385399.

16.S Miranzi Sde , SA de Moraes , IC de Freitas . Impact of the Haemophilus influenzae type b vaccination program on HIB meningitis in Brazil. Cadernos de Saude Publica. 2007; 23: 16891695.

17.PT Heath , J McVernon . The UK Hib vaccine experience. Archives of Disease in Childhood. 2002; 86: 396399.

18.JD Wenger . Epidemiology of Haemophilus influenzae type b disease and impact of Haemophilus influenzae type b conjugate vaccines in the United States and Canada. Pediatric Infectious Disease Journal. 1998; 17 (Suppl. 9):132136.

19.S Ladhani , Invasive Haemophilus influenzae disease, Europe, 1996–2006. Emerging Infectious Diseases 2010; 16: 455463.

20.ML Barbour , RT Mayon-White . The impact of conjugate vaccine on carriage of Haemophilus influenzae type b. Journal of Infectious Diseases 1995; 171: 9398.

21. JMcVernon , Trends in Haemophilus influenzae type b infections in adults in England and Wales: surveillance study. British Medical Journal 2004; 329: 655658.

22.H Dabernat , Haemophilus influenzae carriage in children attending French day care centers: a molecular epidemiological study. Journal of Clinical Microbiology 2003; 41: 16641672.

23.MS Dworkin , L Park , SM Borchardt . The changing epidemiology of invasive Haemophilus influenzae disease, especially in persons ⩾65 years old. Clinical Infectious Diseases 2007; 44: 810816.

24.AK Takala , Reduction of oropharyngeal carriage of Haemophilus influenzae type b (Hib) in children immunized with an Hib conjugate vaccine. Journal of Infectious Diseases 1991; 164: 982986.

25.S Ladhani , No evidence for Haemophilus influenzae serotype replacement in Europe after introduction of the Hib conjugate vaccine. Lancet Infectious Disease 2008; 8: 275276.

26.J McVernon , ME Ramsay , AR McLean . Understanding the impact of Hib conjugate vaccine on transmission, immunity and disease in the United Kingdom. Epidemiology and Infection 2008; 136: 800812.

27.P Bajanca , M Caniça , and the Multicenter Study Group. Emergence of non-encapsulated and encapsulated non-type-b invasive Haemophilus influenzae isolates in Portugal 1989–2001. Journal of Clinical Microbiology 2004; 42: 807810.

28.GS Ribeiro , Prevention of Haemophilus influenzae type b (Hib) meningitis and emergence of serotype replacement with type a strains after introduction of Hib immunization in Brazil. Journal of Infectious Diseases 2003; 187: 109116.

33. HPeltola . Haemophilus influenzae type b disease and vaccination in Europe: lessons learned. Pediatric Infectious Disease Journal. 1998; 17 (Suppl.9): 126132.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Type Description Title
EXCEL
Supplementary Materials

Levy-Bruhl Supplementary Material
Appendix

 Excel (48 KB)
48 KB