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Part II. Analysis of data gaps pertaining to Shigella infections in low and medium human development index countries, 1984–2005

  • P. K. RAM (a1) (a2), J. A. CRUMP (a2), S. K. GUPTA (a2), M. A. MILLER (a3) and E. D. MINTZ (a2)...
Abstract
SUMMARY

The global incidence of Shigella infection has been estimated at 80–165 million episodes annually, with 99% of episodes occurring in the developing world. To identify contemporary gaps in the understanding of the global epidemiology of shigellosis, we conducted a review of the English-language scientific literature from 1984 to 2005, restricting the search to low and medium human development countries. Our review yielded 11 population-based studies of Shigella burden from seven countries. No population-based studies have been conducted in sub-Saharan Africa or in low human development countries. In studies done in all age groups, Shigella incidence varied from 0·6 to 107 episodes/1000 person-years. S. flexneri was the most commonly detected subgroup in the majority of studies. Case-fatality rates ranged from 0% to 2·6% in population-based studies and from 0% to 21% in facility-based studies. This review highlights the large gaps in data on the burden of Shigella infections for low human development index countries and, more specifically, for sub-Saharan Africa.

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Corresponding author
*Author for correspondence: P. K. Ram, M.D., Research Assistant Professor, Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Rm. 273 Farber Hall, 3435 Main Street, Buffalo, NY 14214, USA. (Email: pkram@buffalo.edu)
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2. HL DuPont , Inoculum size in shigellosis and implications for expected mode of transmission. Journal of Infectious Diseases 1989; 159: 11261128.

8. AH Baqui , Enteropathogens associated with acute and persistent diarrhea in Bangladeshi children less than 5 years of age. Journal of Infectious Diseases 1992; 166: 792796.

20. M Casalino , A two-year study of enteric infections associated with diarrhoeal diseases in children in urban Somalia. Transactions of the Royal Society of Tropical Medicine & Hygiene 1988; 82: 637641.

21. DR Diniz-Santos , Epidemiological and microbiological aspects of acute bacterial diarrhea in children from Salvador, Bahia, Brazil. Brazilian Journal of Infectious Diseases 2005; 9: 7783.

25. K Khalil , Early child health in Lahore, Pakistan: VIII. Microbiology. Acta Paediatrica 1993; 82 (Suppl. 390): 8794.

29. JO Osisanya , Acute diarrhoeal disease in Nigeria: detection of enteropathogens in a rural sub-Saharan population. Transactions of the Royal Society of Tropical Medicine & Hygiene 1988; 82: 773777.

35. GP Pazhani , Clonal multidrug-resistant Shigella dysenteriae type 1 strains associated with epidemic and sporadic dysenteries in eastern India. Antimicrobial Agents & Chemotherapy 2004; 48: 681684.

37. A Naheed , Fluoroquinolone-resistant Shigella dysenteriae type 1 in northeastern Bangladesh [Comment]. Lancet Infectious Diseases 2004; 4: 607608.

38. K Sarkar , Shigella dysenteriae type 1 with reduced susceptibility to fluoroquinolones. Lancet 2003; 361: 785.

39. D Sur , Multidrug-resistant Shigella dysenteriae type 1: forerunners of a new epidemic strain in eastern India? Emerging Infectious Diseases 2003; 9: 404405.

41. S Dutta , Shigella dysenteriae serotype 1, Kolkata, India. Emerging Infectious Diseases 2003; 9: 14711474.

48. KA Talukder , Phenotypic and genotypic characterization of provisional serotype Shigella flexneri 1c and clonal relationships with 1a and 1b strains isolated in Bangladesh. Journal of Clinical Microbiology 2003; 41: 110117.

50. WA Khan , Central nervous system manifestations of childhood shigellosis: prevalence, risk factors, and outcome. Pediatrics 1999; 103: E18.

52. CW Hoge , Emergence of nalidixic acid resistant Shigella dysenteriae type 1 in Thailand: an outbreak associated with consumption of a coconut milk dessert. International Journal of Epidemiology 1995; 24: 12281232.

54. MO Rawashdeh , Shigellosis in Jordanian children: a clinico-epidemiologic prospective study and susceptibility to antibiotics. Journal of Tropical Pediatrics 1994; 40: 355359.

56. BR Thapa , Shigellosis in children from north India: a clinicopathological study. Journal of Tropical Pediatrics 1995; 41: 303307.

57. N Dewan , Nutritional status and diarrhoeal pathogen in hospitalized children in Bangladesh. Acta Paediatrica 1998; 87: 627630.

59. F Ahmed , Epidemiology of postshigellosis persistent diarrhea in young children. Pediatric Infectious Disease Journal 2001; 20: 525530.

60. ML Bennish , Intestinal obstruction during shigellosis: incidence, clinical features, risk factors, and outcome. Gastroenterology 1991; 101: 626634.

63. S Al-Qarawi , An outbreak of hemolytic uremic syndrome associated with antibiotic treatment of hospital inpatients for dysentery. Emerging Infectious Diseases 1995; 1: 138140.

64. R Bhimma , Post-dysenteric hemolytic uremic syndrome in children during an epidemic of Shigella dysentery in Kwazulu/Natal. Pediatric Nephrology 1997; 11: 560564.

65. T Butler , Risk factors for development of hemolytic uremic syndrome during shigellosis. Journal of Pediatrics 1987; 110: 894897.

68. T Martin , Shigellosis with bacteremia: a report of two cases and a review of the literature. Pediatric Infectious Disease 1983; 2: 2126.

69. M Kristjansson , Polymicrobial and recurrent bacteremia with Shigella in a patient with AIDS [see Comment]. Scandinavian Journal of Infectious Diseases 1994; 26: 411416.

70. A Khan , Presumptive shigellosis: clinical and laboratory characteristics of Bangladeshi patients. Scandinavian Journal of Infectious Diseases 2005; 37: 96100.

71. ML Bennish , BJ Wojtyniak . Mortality due to shigellosis: community and hospital data. Reviews of Infectious Diseases 1991; 13 (Suppl. 4): S245251.

72. ML Bennish , Death in shigellosis: incidence and risk factors in hospitalized patients [Erratum appears in Journal of Infectious Diseases 1990; 162: 573]. Journal of Infectious Diseases 1990; 161: 500506.

73. SS Islam , NS Shahid . Morbidity and mortality in a diarrhoeal diseases hospital in Bangladesh. Transactions of the Royal Society of Tropical Medicine & Hygiene 1986; 80: 748752.

76. DG Pillay , Nosocomial transmission of Shigella dysenteriae type 1. Journal of Hospital Infection 1997; 37: 199205.

77. EG Goma . Public health impact of Rwandan refugee crisis: what happened in Goma, Zaire, in July, 1994? Lancet 1995; 345: 339344.

80. PJ Guerin , Shigella dysenteriae serotype 1 in west Africa: intervention strategy for an outbreak in Sierra Leone. Lancet 2003; 362: 705706.

83. J Tuttle , Antimicrobial-resistant epidemic Shigella dysenteriae type 1 in Zambia: modes of transmission. Journal of Infectious Diseases 1995; 171: 371375.

84. NC Rollins , Epidemic Shigella dysenteriae type 1 in Natal. Journal of Tropical Pediatrics 1995; 41: 281284.

85. JP Nataro . Vaccines against diarrheal diseases. Seminars in Pediatric Infectious Diseases 2004; 15: 272279.

86. M Iwamoto , Shigellosis among swimmers in a freshwater lake. Southern Medical Journal 2005; 98: 774778.

87. AM Maurer , D Sturchler . A waterborne outbreak of small round structured virus, campylobacter and shigella co-infections in La Neuveville, Switzerland, 1998. Epidemiology & Infection 2000; 125: 325332.

88. SM Midzi , An outbreak of dysentery in a rural district of Zimbabwe: the role of personal hygiene at public gatherings. Central African Journal of Medicine 2000; 46: 150153.

89. E Mitscherlich . Microbial Survival in the Environment. New York: Springer-Verlag, 1984.

91. OS Levine , MM Levine . Houseflies (Musca domestica) as mechanical vectors of shigellosis. Reviews of Infectious Diseases 1991; 13: 688696.

92. D Cohen , Reduction of transmission of shigellosis by control of houseflies (Musca domestica). Lancet 1991; 337: 993997.

95. MU Khan . Interruption of shigellosis by hand washing. Transactions of the Royal Society of Tropical Medicine & Hygiene 1982; 76: 164168.

96. JC Mohle-Boetani , Communitywide shigellosis: control of an outbreak and risk factors in child day-care centers. American Journal of Public Health 1995; 85: 812816.

101. M Salam , Evaluation of the Premier Enterohemorrhagic Escherichia coli (EHEC) assay for detection of Shigella dysenteriae type 1 (Sd 1) infection. In: Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago: American Society of Microbiology, 2001.

102. KC Hayani , Concentration of milk secretory immunoglobulin A against Shigella virulence plasmid-associated antigens as a predictor of symptom status in Shigella-infected breast-fed infants. Journal of Pediatrics 1992; 121: 852856.

103. UD Parashar , Global illness and deaths caused by rotavirus disease in children. Emerging Infectious Diseases 2003; 9: 565572.

106. DF Wittenberg . The spread of Shigella dysenteriae type I in Africa. Japanese Journal of Medical Science & Biology 1998; 51 (Suppl.): S3642.

107. I Kabir , Comparative efficacies of single intravenous doses of ceftriaxone and ampicillin for shigellosis in a placebo-controlled trial. Antimicrobial Agents & Chemotherapy 1986; 29: 645648.

108. I Kabir , Comparative efficacies of pivmecillinam and ampicillin in acute shigellosis. Antimicrobial Agents & Chemotherapy 1984; 25: 643645.

109. D Brenner . Recommendations on Recent Proposals for the Classification of Shigellae. International Journal of Systematic Bacteriology 1984; 34: 8788.

110. KA Talukder , Altering trends in the dominance of Shigella flexneri serotypes and emergence of serologically atypical S. flexneri strains in Dhaka, Bangladesh. Journal of Clinical Microbiology 2001; 39: 37573759.

113. L Von Seidlein , A multicentre study of Shigella diarrhoea in six Asian countries: disease burden, clinical manifestations, and microbiology. PLOS Medicine 2006; 3.

114. PJ Sansonetti . Shigellosis: an old disease in new clothes. PLOS Medicine 2006; 3: e354.

122. RL Shapiro , Antimicrobial-resistant bacterial diarrhea in rural western Kenya. Journal of Infectious Diseases 2001; 183: 17011704.

123. D Sen , Studies on Escherichia coli as a cause of acute diarrhoea in Calcutta. Journal of Medical Microbiology 1984; 17: 5358.

124. P Echeverria , Identification by DNA hybridization of enterotoxigenic Escherichia coli in a longitudinal study of villages in Thailand. Journal of Infectious Diseases 1985; 151: 124130.

127. P Echeverria , Etiology of diarrhea in a rural community in western Thailand: importance of enteric viruses and enterovirulent Escherichia coli. Journal of Infectious Diseases 1994; 169: 916919.

129. BA Oyofo , Surveillance of bacterial pathogens of diarrhea disease in Indonesia. Diagnostic Microbiology & Infectious Disease 2002; 44: 227234.

130. DS Subekti , Prevalence of enterotoxigenic Escherichia coli (ETEC) in hospitalized acute diarrhea patients in Denpasar, Bali, Indonesia. Diagnostic Microbiology & Infectious Disease 2003; 47: 399405.

131. SK Jain , Antimicrobial-resistant Shigella sonnei: limited antimicrobial treatment options for children and challenges of interpreting in vitro azithromycin susceptibility. Pediatric Infectious Disease Journal 2005; 24: 494497.

137. C Seas , Surveillance of bacterial pathogens associated with acute diarrhea in Lima, Peru. International Journal of Infectious Diseases 2000; 4: 9699.

140. M Moyenuddin , The aetiology of diarrhoea in children at an urban hospital in Bangladesh. Transactions of the Royal Society of Tropical Medicine & Hygiene 1987; 81: 299302.

142. T Ise , Clinical evaluation and bacterial survey in infants and young children with diarrhoea in the Santa Cruz district, Bolivia. Journal of Tropical Pediatrics 1994; 40: 369374.

144. TinAye, Epidemiology and aetiology of acute childhood diarrhoea in Burma: a rural community survey. Transactions of the Royal Society of Tropical Medicine & Hygiene 1989; 83: 827830.

145. IA Mikhail , Microbiologic and clinical study of acute diarrhea in children in Aswan, Egypt. Scandinavian Journal of Infectious Diseases 1989; 21: 5965.

147. P Echeverria , Case-control study of endemic diarrheal disease in Thai children [Erratum appears in Journal of Infectious Diseases 1989; 160: 182]. Journal of Infectious Diseases 1989; 159: 543548.

148. TI Ogunsanya , A study of the aetiological agents of childhood diarrhoea in Lagos, Nigeria. Journal of Medical Microbiology 1994; 40: 1014.

150. T Nakano , Diagnosis of bacterial enteric infections in children in Zambia. Acta Paediatrica Japonica 1998; 40: 259263.

152. M Youssef , Bacterial, viral and parasitic enteric pathogens associated with acute diarrhea in hospitalized children from northern Jordan. FEMS Immunology & Medical Microbiology 2000; 28: 257263.

157. MK Bhan , Enteroaggregative Escherichia coli associated with persistent diarrhea in a cohort of rural children in India. Journal of Infectious Diseases 1989; 159: 10611064.

160. MK Mackenjee , Aetiology of diarrhoea in adequately nourished young African children in Durban, South Africa. Annals of Tropical Paediatrics 1984; 4: 183187.

161. TA Gomes , Enteropathogens associated with acute diarrheal disease in urban infants in Sao Paulo, Brazil. Journal of Infectious Diseases 1991; 164: 331337.

162. ZF Ming , Diarrhoeal disease in children less than one year of age at a children's hospital in Guangzhou, People's Republic of China. Transactions of the Royal Society of Tropical Medicine & Hygiene 1991; 85: 667669.

163. RV Lawande , RM Joshi . Shigellosis in Zaria, northern Nigeria. Transactions of the Royal Society of Tropical Medicine & Hygiene 1987; 81: 10141016.

166. A Mache . Antibiotic resistance and serogroups of shigella among paediatric out-patients in southwest Ethiopia. East African Medical Journal 2001; 78: 296299.

169. KZ Mamun , Antimicrobial susceptibility of Shigella from a rural community in Bangladesh. Annals of Tropical Medicine & Parasitology 1997; 91: 643647.

172. BM Nguyen , Age-related prevalence of Shigella and Salmonella antibodies and their association with diarrhoeal diseases in Peruvian children. Scandinavian Journal of Infectious Diseases 1998; 30: 159164.

174. AA Ries , Epidemic Shigella dysenteriae type 1 in Burundi: panresistance and implications for prevention. Journal of Infectious Diseases 1994; 169: 10351041.

175. MS Islam , Microbiological investigation of diarrhoea epidemics among Rwandan refugees in Zaire. Transactions of the Royal Society of Tropical Medicine & Hygiene 1995; 89: 506.

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