Skip to main content
×
Home
    • Aa
    • Aa

Prevalence, risk factors and molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) colonization in residents of long-term care facilities in Luxembourg, 2010

  • J. MOSSONG (a1), E. GELHAUSEN (a2), F. DECRUYENAERE (a3), A. DEVAUX (a1), M. PERRIN (a3), J. EVEN (a4) and E. HEISBOURG (a2)...
Abstract
SUMMARY

A prevalence survey of methicillin-resistant Staphylococcus aureus (MRSA) was performed in 2010 in 19 long-term care facilities in Luxembourg. Of the 954 participating residents, 69 (7·2%) were colonized by MRSA. Previous history of MRSA [odds ratio (OR) 7·20, 95% confidence interval (CI) 3·19–16·27], quinolone therapy in the previous year (OR 2·27, 95% CI 1·17–4·41) and ⩾24 h care administered per week (OR 4·29, 95% CI 1·18–15·56) were independent risk factors for MRSA colonization. More than 75% of strains were of clonal complex (CC)5, mainly spa-type t003 or sequence type (ST)225 and ST710, which is a rapidly emerging lineage prevalent in central Europe. Five residents were colonized by livestock-associated genotypes belonging to CC398. Previously dominant CC8 strains have recently been replaced by more resistant CC5 strains in Luxembourg.

Copyright
Corresponding author
*Author for correspondence: Dr J. Mossong, Surveillance & Epidemiology of Infectious Diseases, National Health Laboratory, 42 rue du Laboratoire, L-1911 Luxembourg, Luxembourg. (Email: joelmossong@gmail.com)
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

2.A Manzur , F Gudiol . Methicillin-resistant Staphylococcus aureus in long-term-care facilities. Clinical Microbiology and Infection 2009; 15 (Suppl. 7): 2630.


4.G Daeschlein , Risk factors for Staphylococcus aureus nasal carriage in residents of three nursing homes in Germany. Journal of Hospital Infection 2006; 63: 216220.


6.R Woltering , Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in patients in long-term care in hospitals, rehabilitation centers and nursing homes of a rural district in Germany. Deutsche Medizinische Wochenschrift 2008; 133: 9991003.

8.C Suetens , Determinants of methicillin-resistant Staphylococcus aureus carriage in nursing homes. Age and Ageing 2007; 36: 327330.

9.S Pfingsten-Würzburg , Prevalence and molecular epidemiology of meticillin-resistant Staphylococcus aureus in nursing home residents in northern Germany. Journal of Hospital Infection 2011; 78: 108112.

10.P Brugnaro , Clustering and risk factors of methicillin-resistant Staphylococcus aureus carriage in two Italian long-term care facilities. Infection 2009; 37: 216221.



13.A Manzur , Prevalence of methicillin-resistant Staphylococcus aureus and factors associated with colonization among residents in community long-term-care facilities in Spain. Clinical Microbiology and Infection 2008; 14: 867872.

14.O Denis , Epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) among residents of nursing homes in Belgium. Journal of Antimicrobial Chemotherapy 2009; 64: 12991306.


16.M Eveillard , Methicillin-resistant Staphylococcus aureus carriage in a long-term care facility: hypothesis about selection and transmission. Age and Ageing 2008; 37: 294299.

17.DC Oliveira , Comparison of DNA sequencing of the protein A gene polymorphic region with other molecular typing techniques for typing two epidemiologically diverse collections of methicillin-resistant Staphylococcus aureus. Journal of Clinical Microbiology 2001; 39: 574580.

18.L Koreen , spa typing method for discriminating among Staphylococcus aureus isolates: implications for use of a single marker to detect genetic micro- and macrovariation. Journal of Clinical Microbiology 2004; 42: 792799.

19.C Baum , Non-spa-typeable clinical Staphylococcus aureus strains are naturally occurring protein A mutants. Journal of Clinical Microbiology 2009; 47: 36243629.

21.M Dulon , MRSA prevalence in European healthcare settings: a review. BMC Infectious Diseases 2011; 11: 138.

22.MW Ribbe , Nursing homes in 10 nations: a comparison between countries and settings. Age and Ageing 1997; 26 (Suppl. 2): 312.

23.RH Deurenberg , C Vink , S Kalenic , The molecular evolution of methicillin-resistant Staphylococcus aureus. Clinical Microbiology and Infection 2007; 13: 222235.

24.M Wolters , MALDI-TOF MS fingerprinting allows for discrimination of major methicillin-resistant Staphylococcus aureus lineages. International Journal of Medical Microbiology 2011; 301: 6468.

26.U Nubel , A timescale for evolution, population expansion, and spatial spread of an emerging clone of methicillin-resistant Staphylococcus aureus. PLoS Pathogens 2010; 6: e1000855.

27.H Grundmann , Geographic distribution of Staphylococcus aureus causing invasive infections in Europe: a molecular-epidemiological analysis. PLoS Medicine 2010; 7: e1000215.

28.I van Loo , Emergence of methicillin-resistant Staphylococcus aureus of animal origin in humans. Emerging Infectious Diseases 2007; 13: 18341839.

29.AE Waters , Multidrug-resistant Staphylococcus aureus in US meat and poultry. Clinical Infectious Diseases 2011; 52: 12271230.

30.SR Harris , Evolution of MRSA during hospital transmission and intercontinental spread. Science 2010; 327: 469474.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Type Description Title
WORD
Supplementary Materials

Mossong Supplementary Material
Supplementary Material.doc

 Word (264 KB)
264 KB