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Report of a hospital neonatal unit outbreak of community-associated methicillin-resistant Staphylococcus aureus

  • I. M. GOULD (a1), E. K. GIRVAN (a2), R. A. BROWNING (a3), F. M. MACKENZIE (a1) and G. F. S. EDWARDS (a2)...
Abstract
SUMMARY

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) with the type IV staphylococcal chromosomal cassette mec (SCCmec) is rarely reported as being acquired in hospital. We report a hospital outbreak, in Grampian, Scotland, of eight cases of skin and soft-tissue infections due to such a strain. All patients had been in the labour, delivery and maternity units of a small community hospital during a 7-month period. Typing by pulsed-field gel electrophoresis showed the isolates to be a single strain closely related to the USA800 lineage (paediatric clone) and additional typing confirmed it as ST5-MRSA-IV. Genes for exfoliative toxin A (ETA) and enterotoxin D were detected by PCR in all the isolates although none carried the Panton–Valentine leukocidin gene. Region-wide surveillance of over 6000 MRSA isolates collected from 1998 to 2004 showed that 95 (1·6%) were closely related to the outbreak strain although only 60 carried the ETA gene. The strain has not been seen elsewhere in Scotland.

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Corresponding author
*Author for correspondence: Dr I. M. Gould, Department of Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, AB25 2ZN, UK. (Email: i.m.gould@abdn.ac.uk)
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1.BC Herold , Community-acquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk. Journal of the American Medical Association 1998; 279: 593598.

2.TS Naimi , Comparison of community and healthcare-associated methicillin-resistant Staphylococcus aureus infection. Journal of the American Medical Association 2003; 290: 29762984.

4.K Mongkolrattanothai , Severe Staphylococcus aureus infections caused by clonally related community-acquired methicillin-susceptible and methicillin-resistant isolates. Clinical Infectious Diseases 2003; 37: 10501058.

7.L Saiman , Hospital transmission of community-acquired methicillin resistant Staphylococcus aureus among postpartum women. Infectious Diseases 2003; 37: 13131319.

8.H Sax , Control of a cluster of commuity-associated, methicillin-resisant Staphylococcus aureus in neonatology. Journal of Hospital Infection 2006; 63: 93100.

9.FM MacKenzie , Identification and characterization of teicoplanin-intermediate Staphylococcus aureus blood culture isolates in NE Scotland. Journal of Antimicrobial Chemotherapy 2002; 50: 689697.

13.G Lina , Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia. Clinical Infectious Diseases 1999; 29: 11281132.

16.DC Oliveira , H de Lencastre . Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 2002; 46: 21552161.

18.H de Almeida Silva , Infection and colonisation by Staphylococcus aureus in a high risk nursery of a Brazilian teaching hospital. Brazilian Journal of Infectious Diseases 2003; 7: 381386.

19.HF Chambers . Community-associated MRSA – resistance and virulence converge. New England Journal of Medicine 2005; 352: 14851487.

21.SK Fridkin , Methicillin-resistant Staphylococcus aureus disease in three communities. New England Journal of Medicine 2005; 352: 14851487.

22.P Seetulsingh , C Curtis , AM Kearns . Outbreak of ciprofloxacin-susceptible community-associated methicillin-resistant Staphylococcus aureus in a neonatal unit. Journal of Hospital Infection 2008; 68: 374375.

23.JA Otter , Identification and control of an outbreak of ciprofloxacin-susceptible EMRSA-15 on a neonatal unit. Journal of Hospital Infection 2007; 67: 232239.

24.MD David , Community-associated MRSA: nosocomial transmission in a neonatal unit. Journal of Hospital Infection 2006; 64: 244250.

26.IM Gould . Community-acquired MRSA: can we control it? Lancet 2006; 368: 824826.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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