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Retrospective survey of Chikungunya disease in Réunion Island hospital staff

  • F. STAIKOWSKY (a1), K. Le ROUX (a2), I. SCHUFFENECKER (a3), P. LAURENT (a2), P. GRIVARD (a2), A. DEVELAY (a1) and A. MICHAULT (a2)...

Réunion Island (Indian Ocean) has been suffering from its first known Chikungunya virus (CHIKV) epidemic since February 2005. To achieve a better understanding of the disease, a questionnaire was drawn up for hospital staff members and their household. CHIKV infected about one-third of the studied population, the proportion increasing with age and being higher in women. Presence of a garden was associated with CHIKV infection. The geographical distribution of cases was concordant with insect vector Aedes albopictus distribution. The main clinical signs were arthralgia and fever. The disease evolved towards full recovery in 34·4% of cases, a relapse in 55·6%, or a chronic form in 10%. Paracetamol was used as a painkiller in 95% of cases, sometimes associated with non-steroidal anti-inflammatory drugs, corticoids, or traditional herbal medicine. The survey provided valuable information on the factors that favour transmission, the clinical signs, the importance of relapses and the therapies used.

Corresponding author
*Author for correspondence: Dr A. Michault, Service de Bactériologie-Parasitologie-Virologie et Hygiène, Groupe Hospitalier Sud RéunionBP 350, 97448Saint Pierre, La Réunion, France. (Email:
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1. JH Porterfield . Antigenic characteristics and classification of the Togaviridae. In: R Schlesinger ed. The Togaviruses. New York: Academic Press, 1980, pp. 1346.

2. WH Lumsden . An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952–53 II. General description and epidemiology. Transactions of the Royal Society of Tropical Medicine and Hygiene 1955; 49: 3357.

3. WM Hammon , Viruses associated with epidemic hemorrhagic fevers of the Philippines and Thailand. Science 1960; 131: 11021103.

5. C Paquet , Chikungunya outbreak in Reunion: epidemiology and surveillance, 2005 to early January 2006. Eurosurveillance 2006; 11: E0602023.

6. PY Robillard , Vertical maternal fetal transmission of the chikungunya virus. Ten cases among 84 pregnant women [in French]. Presse Médicale 2006; 35: 785788.

11. I Schuffenecker , Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak. PLoS Medicine 2006; 3: e263.

13. MC Robinson . An epidemic of virus disease in southern province, Tanganyika territory, in 1952–53. Transactions of the Royal Society of Tropical Medicine and Hygiene 1955; 49: 2832.

16. AC Kennedy , Chikungunya viral arthropathy: a clinical description. Journal of Rheumatology 1980; 7: 231236.

17. NE Rulli , Ross River virus: molecular and cellular aspects of disease pathogenesis. Pharmacology and Therapeutics 2005; 107: 329342.

18. J Thonnon , Chikungunya virus outbreak in Senegal in 1996 and 1997 [in French]. Bulletin de la Société de Pathologie Exotique 1999; 92: 7982.

19. P Osterrieth , Research on the Chikungunya virus in the Belgian Congo. I. Isolation of the virus in upper Uele [in French]. Annales de la Société Belge de Médecine Tropicale 1960; 40: 199203.

20. MT Heise , Sindbis-group alphavirus replication in periosteum and endosteum of long bones in adult mice. Journal of Virology 2000; 74: 92949299.

21. M Soden , Detection of viral ribonucleic acid and histologic analysis of inflamed synovium in Ross River virus infection. Arthritis & Rheumatism 2000; 43: 365369.

23. A Savarino , New insights into the antiviral effects of chloroquine. Lancet Infectious Diseases 2006; 6: 6769.

24. S Briolant , In vitro inhibition of Chikungunya and Semliki Forest viruses replication by antiviral compounds: synergistic effect of interferon-alpha and ribavirin combination. Antiviral Research 2004; 61: 111117.

25. F Staikowsky , Emergency services in Réunion Island and the Chikungunya virus. What if it was Avian flu virus? [in French]. Journal Européen des Urgences 2006; 19: 5960.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
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