Skip to main content
×
Home
    • Aa
    • Aa

Risk factors for encephalitis and death from West Nile virus infection

  • K. MURRAY (a1) (a2), S. BARANIUK (a1), M. RESNICK (a1), R. ARAFAT (a3), C. KILBORN (a4), K. CAIN (a1), R. SHALLENBERGER (a3), T. L. YORK (a4), D. MARTINEZ (a4), J. S. HELLUMS (a1) (a5), D. HELLUMS (a6), M. MALKOFF (a5), N. ELGAWLEY (a3), W. McNEELY (a3), S. A. KHUWAJA (a3) and R. B. TESH (a2)...
Abstract

We conducted a nested case-control study to determine potential risk factors for developing encephalitis from West Nile virus (WNV) infection. Retrospective medical chart reviews were completed for 172 confirmed WNV cases hospitalized in Houston between 2002 and 2004. Of these cases, 113 had encephalitis, including 17 deaths, 47 had meningitis, and 12 were fever cases; 67% were male. Homeless patients were more likely to be hospitalized from WNV compared to the general population. A multiple logistic regression model identified age [odds ratio (OR) 1·1, P<0·001], history of hypertension, including those cases taking hypertension-inducing drugs (OR 2·9, P=0·012), and history of cardiovascular disease (OR 3·5, P=0·061) as independent risk factors for developing encephalitis from WNV infection. After adjusting for age, race/ethnicity (being black) (OR 12·0, P<0·001), chronic renal disease (OR 10·6, P<0·001), hepatitis C virus (OR 23·1, P=0·0013), and immunosuppression (OR 3·9, P=0·033) were identified as risk factors for death from WNV infection.

Copyright
Corresponding author
1200 Herman Pressler, Rm. 707, Houston, TX 77030, USA. (Email: Kristy.O.Murray@uth.tmc.edu)
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Altmetric attention score