Skip to main content
×
Home
    • Aa
    • Aa

Campylobacter seroconversion rates in selected countries in the European Union

  • P. F. M. TEUNIS (a1) (a2), G. FALKENHORST (a3), C. W. ANG (a4), M. A. STRID (a3), H. DE VALK (a5), M. SADKOWSKA-TODYS (a6), L. ZOTA (a7), M. KUUSI (a8), M. C. ROTA (a9), J. B. SIMONSEN (a3), K. MØLBAK (a3), Y. T. H. P. VAN DUYNHOVEN (a1) and W. VAN PELT (a1)...
Abstract
SUMMARY

As a major foodborne pathogen, Campylobacter is frequently isolated from food sources of animal origin. In contrast, human Campylobacter illness is relatively rare, but has a considerable health burden due to acute enteric illness as well as severe sequelae. To study silent transmission, serum antibodies can be used as biomarkers to estimate seroconversion rates, as a proxy for infection pressure. This novel approach to serology shows that infections are much more common than disease, possibly because most infections remain asymptomatic. This study used antibody titres measured in serum samples collected from healthy subjects selected randomly in the general population from several countries in the European Union (EU). Estimates of seroconversion rates to Campylobacter were calculated for seven countries: Romania, Poland, Italy, France, Finland, Denmark and The Netherlands. Results indicate high infection pressures in all these countries, slightly increasing in Eastern EU countries. Of these countries, the differences in rates of notified illnesses are much greater, with low numbers in France and Poland, possibly indicating lower probability of detection due to differences in the notification systems, but in the latter case it cannot be excluded that more frequent exposure confers better protection due to acquired immunity.

Copyright
Corresponding author
*Author for correspondence: P. F. M. Teunis, Ph.D., National Institute of Public Health and the Environment, Centre for Infectious Disease Control, Anthonie van Leeuwenhoeklaan 9, 3721MA Bilthoven, The Netherlands. (Email: peter.teunis@rivm.nl)
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1.GM Ruiz-Palacios . The health burden of Campylobacter infection and the impact of antimicrobial resistance: playing chicken [Editorial commentary]. Clinical Infectious Diseases 2007; 44: 701703.

2.K Kubota , Estimating the burden of acute gastroenteritis and foodborne illness caused by Campylobacter, Salmonella, and Vibrio parahaemolyticus by using population-based telephone survey data, Miyagi Prefecture, Japan, 2005 to 2006. Journal of Food Protection 2011; 74: 15921598.

3.AH Havelaar , Disease burden of foodborne pathogens in the Netherlands, 2009. International Journal of Food Microbiology 2012a; 156: 231238.

6.CW Ang , BC Jacobs , JD Laman . The Guillain-Barré syndrome: a true case of molecular mimicry. Trends in Immunology 2004; 25: 6166.

7.CC Tam , Guillain–Barré syndrome and preceding infection with Campylobacter, influenza and Epstein– Barr virus in the general practice research database. PLoS ONE 2007; 2: e344.

8.MAS de Wit , Sensor, a population-based cohort study on gastroenteritis in the Netherlands: incidence and etiology. American Journal of Epidemiology 2001; 154: 666674.

9.CFL Amar , Detection by PCR of eight groups of enteric pathogens in 4,627 faecal samples: re-examination of the English case-control Infectious Intestinal Disease Study (1993–1996). European Journal of Clinical Microbiology and Infectious Diseases 2007; 26: 311323.

10.RH Madden , L Moran , P Scates . Frequency of occurrence of Campylobacter spp. in red meats and poultry in Northern Ireland and their subsequent subtyping using polymerase chain reaction-restriction fragment length polymorphism and the random amplified polymorphic DNA method. Journal of Applied Microbiology 1998; 84: 703708.

11.SF Altekruse , Campylobacter jejuni – an emerging foodborne pathogen. Emerging Infectious Diseases 1999; 5: 2835.

12.ML Devane , The occurrence of Campylobacter subtypes in environmental reservoirs and potential transmission routes. Journal of Applied Microbiology 2005; 98: 980990.


16.CW Ang , Validation of an ELISA for the diagnosis of recent Campylobacter infections in Guillain-Barré and reactive arthritis patients. Clinical Microbiology and Infection 2007; 13: 915922.


18.G Falkenhorst , Serological cross-sectional studies on Salmonella incidence in eight European countries: no correlation with incidence of reported cases. BMC Public Health 2012; 12: 523523.


20.J Simonsen , Estimation of incidences of infectious diseases based on antibody measurements. Statistics in Medicine 2009; 28: 18821895.


22.PFM Teunis , Biomarker dynamics: estimating infection rates from serological data. Statistics in Medicine 2012; 31: 22402248.


25.RE Black , Experimental Campylobacter jejuni infection in humans. Journal of Infectious Diseases 1988; 157: 472479.

26.ME Hellard , Prevalence of enteric pathogens among community based asymptomatic individuals. Journal of Gastroenterology and Hepatology 2000; 15: 290293.

29.AN Swart , The protective effects of temporary immunity under imposed infection pressure. Epidemics 2012; 4: 4347.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: