Skip to main content
    • Aa
    • Aa

The effect of CMV infection on progression of human immunodeficiency virus disease in a cohort of haemophilic men followed for up to 13 years from seroconversion

  • C. A. Sabin (a1), A. N. Phillips (a1), C. A. Lee (a2), G. Janossy (a3), V. Emery (a4) and P. D. Griffiths (a4)...

The effect of prior infection with cytomegalovirus (CMV) on progression of HIV disease in a cohort of 111 men with haemophilia was studied after 13 years followup. The relative hazards associated with CMV positivity on progression to AIDS, death and a CD4 count of 0·05 × 109/1 were 2·28, 2·42 and 2·34, respectively. CMV seropositive patients were significantly older than the seronegative and this was controlled for by using a Cox proportional hazards model. The relative hazards for the three endpoints decreased to 1·89, 1·82 and 1·93 respectively and were marginally non-significant (P = 0·05, 0·08 and 0·08 for the three endpoints respectively). We conclude that this cohort continues to show evidence of a ‘co-factor’ effect associated with prior infection with CMV which is confounded by age but not completely explained by age differences. The potential biological significance of these results is discussed in the context of recent controlled clinical trials which show a survival benefit from long-term high-dose acyclovir, a drug with activity in vivo against CMV and other herpesviruses.

Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

2. S Chevret , D Costagliola , J Lefrère , A new approach to estimating AIDS incubation times: results in homosexual infected men. J Epidemiol Comm Health 1992; 46: 582–6.

4. AN Phillips , CA Sabin , J Elford , Use of CD4 lymphocyte count to predict long term survival free of AIDS after HIV infection. BMJ 1994; 309: 309–13.

6. HE Gendelman , W Phelps , L Feigenbaum , Transactivation of the human immunodeficiency virus long terminal repeat sequence by DNA viruses. Proc Nat Acad Sci USA 1986; 83: 9759–63.

7. MG Davis , SC Kenney , J Kamine , Immediate-early gene region of human cytomegalovirus transactivates the promoter of human immunodeficiency virus. Proc Nat Acad Sci USA 1987; 84: 8642–6.

10. AR Moss , P Bacchetti , D Osmond , Seropositivity for HIV and the development of AIDS or AIDS-related condition: three-year follow-up of the San Francisco General Hospital Cohort. BMJ 1988; 296: 745–50.

11. A Blaxhult , F Granath , K Lidman , The influence of age on the latency period to AIDS in people infected by HIV through blood transfusion. AIDS 1990; 4: 125–9.

14. PD Griffiths , C Baboonian . A prospective study of primary cytomegalovirus infection during pregnancy: final report. Br J Obstet Gynaecol 1984; 91: 307–15.

15. A Webster , CA Lee , DG Cook , Cytomegalovirus infection and progression towards AIDS in haemophiliacs with human immunodeficiency virus infection. Lancet 1989; ii: 63–6.

23. NJ Berry , JE Grundy , PD Griffiths . Radioimmunoassay for the detection of IgG antibodies to herpes simplex virus and its use as a prognostic indicator of HSV excretion in transplant recipients. J Med Virol 1987; 21: 147–54.

30. A Webster , JE Grundy , CA Lee , Cytomegalovirus infection and progression to AIDS. Lancet 1989; ii: 681.

31. D Pillay , MCI Lipman , CA Lee , A clinico-pathological audit of opportunistic viral infections in HIV-infected patients. AIDS 1993; 7: 969–74.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *


Full text views

Total number of HTML views: 0
Total number of PDF views: 2 *
Loading metrics...

Abstract views

Total abstract views: 11 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 26th May 2017. This data will be updated every 24 hours.