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Epidemiology & Infection Epidemiology & Infection

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Estimating titres and their approximate standard errors in complement fixation tests

Published online by Cambridge University Press:  15 May 2009

R. C. Elston
R. C. Elston
Affiliation:
Research Group in Biometric Medicine, Department of Statistics, University of Aberdeen
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A method is given for obtaining the approximate standard error of the anti-serum (or antigen) maxima titre in the complement fixation test when the maxima line is determined by only two points; the same formulae may be used to obtain a conservative estimate of the standard error when more than two points are available. If the degree of lysis in each reaction mixture can be scored more finely than into the three simple states of ‘no lysis’, ‘partial lysis’ and ‘complete lysis’, then more accurate estimates can be obtained. A method is also given for estimating the concentration of one antiserum (or antigen) relative to that of another when they react homologously.

Type
Research Article
Information
Epidemiology & Infection , Volume 63 , Issue 2 , June 1965 , pp. 201 - 212
Copyright
Copyright © Cambridge University Press 1965

References

Elston, R. C. (1965). A simple method of estimating relative potency from two parabolas. To appear in Biometrics.Google Scholar
Finney, D. J. (1952). Statistical Method in Biological Assay. London: Charles Griffin and Co.Google Scholar
Fulton, F. (1958). The measurement of complement fixation by viruses. Advanc. Virus Res. 5, 247.CrossRefGoogle ScholarPubMed
Fulton, F. & Almeida, J. O. (1962). Linear relationships in complement fixation. J. Hyg., Camb., 60, 95.CrossRefGoogle ScholarPubMed
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