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Evolutionary changes in myxoma virus in Britain: An examination of 222 in naturally occurring strains obtained from 80 counties during the period October–November 1962

  • Frank Fenner (a1) and Paul J. Chapple (a2)
Extract

Samples of lesions containing viable myxoma virus were collected from 222 infected wild rabbits captured in 80 counties of Britain during October–November 1962. They were dispatched by air to Australia and passaged once in domestic rabbits before being tested for their virulence by the intradermal inoculation of groups of six laboratory rabbits with small doses of virus.

The results showed that a wide range of viruses of differing properties now coexist in Britain. Their virulence ranges from very high (99 % lethal) to low (about 50 %), but the majority of strains fall into the grade III virulence group, with estimated case mortality rates varying between 70 and 95%. The viruses also produce disease of varying symptomatology, skin lesions being very prominent, raised or flat. There was no obvious association between lesion type and virulence.

Tests made on the wild rabbits from which the samples were obtained, and on Inoculated domestic rabbits, showed that virulence could not be predicted by gel-diffusion tests.

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COPYRIGHT: © Cambridge University Press 1965
References
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Andrewes, C. H., Thompson, H. V. & Manst, W. (1959). Myxomatosis: present position and future prospects in Great Britain. Nature, Lond., 184, 1179.
Armour, C. J. & Thompson, H. V. (1955). Spread of myxomatosis in the first outbreak in Great Britain. Ann. appl. Biol. 43, 511.
Burnet, F. M. (1955). The Principles of Animal Virology pp. 436–7. New York: Academic Press.
Chapple, P. J. & Bowen, E. T. W. (1963). A note on two attenuated strains of myxoma virus isolated in Great Britain. J. Hyg., Gamb., 61, 161.
Chapple, P. J., Bowen, E. T. W. & Lewis, N. D. (1963). Some observations on the use of the Ouchterlony gel diffusion technique in the study of myxomatosis. J. Hyg., Camb., 61, 373.
Fenner, F. & Marshall, I. D. (1955). Occurrence of attenuated strains of myxoma virus in Europe. Nature, Lond., 176, 782.
Fenner, F. & McIntyre, G. A. (1956). Infectivity titrations of myxoma virus in the rabbit and the developing chick embryo. J. Hyg., Camb., 54, 246.
Fenner, F. & Marshall, I. D. (1957). A comparison of the virulence for European rabbits (Oryctolagus cuniculus) of strains of myxoma virus recovered in the field in Australia, Europe and America. J. Hyg., Camb., 55, 149.
Fenner, F. (1965). Viruses of the myxoma-fibroma subgroup of the poxviruses. II. Comparison of soluble antigens by gel diffusion tests. Aust. J. exp. Biol. 43, 143.
Fenner, F. & Ratcliffe, F. N. (1965). Myxomatosis. Cambridge University Press (in the Press).
Hudson, J. R. & Mansi, W. (1955). Attenuated strains of myxoma virus in England. Vet. Rec. 67, 746.
Jacotot, H., Vallée, A. & Virat, B. (1955). Apparition en France d'un mutant naturellement atténué du virus de Sanarelli. Ann. Inst. Pasteur, 89, 361.
Mansi, W. & Thomas, V. (1958). Serological investigations in the study of myxoma and fibroma viruses. II. The gel diffusion precipitation test. J. comp. Path. 68, 188.
Marshall, I. D. (1959). The influence of ambient temperature on the course of myxomatosis in rabbits. J. Hyg., Camb., 57, 484.
Marshall, I. D. & Fenner, F. (1960). Studies in the epidemiology of infectious myxomatosis of rabbits. VII. The virulence of strains of myxoma virus recovered from Australian wild rabbits between 1951 and 1959. J. Hyg., Camb., 58, 485.
Mead-Briggs, A. R. (1964 a). Some experiments concerning the interchange of rabbit fleas, Spilopsyllus cuniculi (Dale) between living rabbit hosts. J. Anim. Ecol. 33, 13.
Mead-Briggs, A. R. (1964 b). Records of rabbit fleas, Spilopsyllus cuniculi (Dale), from every county in Great Britain with notes on infestation rates. Ent. mon. Mag. 100, 8.
Mead-Briggs, A. R. & Page, R. J. C. (1964). Fleas other than Spilopsyllus cuniculi (Dale), from a collection of rabbits, predominantly myxomatous, obtained throughout Great Britain. Ent. Gaz. 15, 60.
Moses, A. (1911). O virus do mixoma dos coelhos. Mem. Inst. Oswaldo Cruz, 3, 46.
Woodroofe, G. M. & Fenner, F. (1965). Viruses of the myxoma-fibroma subgroup of the poxviruses. I. Growth and plaque production in cultured cells, and cross-protection tests in rabbits. Aust. J. exp. Biol. 43, 123.
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